Hyaluronic Acid for Genital Area

  • Shirlei Schnaider Borelli
  • Mariana Isis Wanczinski
  • Nátalie Schnaider Borelli


Female genitalia lose elasticity and volume with age, like other body areas. In the literature several techniques address the redundancy of the labia minora, but only few reports describe the augmentation of labia majora with hyaluronic acid (HA) (Yavagal S, de Farias TF, Medina CA, Takacs P. Normal vulvovaginal, perineal, and pelvic anatomy with reconstructive considerations. Semin Plast Surg. 2011;25:121–9).

Labia majora augmentation appears to be a safe and efficient technique with a high satisfaction rate. Hyaluronic acid infiltration of the labia majora is able to provide a significant rejuvenation with a simple outpatient procedure (Howard W, Jones III. Gynecologic surgery. In: Townsend Jr CM, Beauchamp RD, Evers BM, Mattox KL, editors. Sabiston textbook of surgery: the biological basis of modern surgical practice. 19th ed. Philadelphia: Elsevier Saunders; 2012. p. 2003–28). The treatment is repeatable and has virtually no complications, and it is reversible. However, further randomized controlled trials are warranted.


  1. 1.
    Hexel D, Dal’Forno T, Caspary P. Tissue augmentation with hyaluronic acid filler for labia majora and mons pubis. Dermatol Surg. 2016;42(7):911–4.CrossRefGoogle Scholar
  2. 2.
    Signorello LB, Harlow BL, Chekos AK, Repke JT. Postpartum sexual functioning and its relationship to perineal trauma: a retrospective cohort study of primiparous women. Am J Obstet Gynecol. 2001;184(5):881–8; discussion 888–90.CrossRefGoogle Scholar
  3. 3.
    Harvey MA. Pelvic floor exercises during and after pregnancy: a systematic review of their role in preventing pelvic floor dysfunction. J Obstet Gynaecol Can. 2003;25:487–98. Scholar
  4. 4.
    Bourguignon LY. Matrix hyaluronan-activated CD44 signaling promotes keratinocyte activities and improves abnormal epidermal functions. Am J Pathol. 2014;184(7):1912–9.CrossRefGoogle Scholar
  5. 5.
    Aguiar P, Hersant B, et al. Novel technique of vulvo-vaginal rejuvenation by lipofilling and injection of combined platelet-rich-plasma and hyaluronic acid: a case-report. SpringerPlus. 2016;5(1):1184.CrossRefGoogle Scholar
  6. 6.
    Tezel A, Fredrickson GH. The science of hyaluronic acid dermal fillers. J Cosmet Laser Ther. 2008;10(1):35–42.CrossRefGoogle Scholar
  7. 7.
    Park HJ, Jung KH, Kim SY, Lee JH, Jeong JY, Kim JH. Hyaluronic acid pulmonary embolism: a critical consequence of an illegal cosmetic vaginal procedure. Thorax. 2010;65(4):360–1.CrossRefGoogle Scholar
  8. 8.
    Felicio Yde A. Labial surgery. Aesthet Surg J. 2007;27:322–8.CrossRefGoogle Scholar

Copyright information

© Springer Nature Switzerland AG 2020

Authors and Affiliations

  • Shirlei Schnaider Borelli
    • 1
  • Mariana Isis Wanczinski
    • 1
  • Nátalie Schnaider Borelli
    • 1
  1. 1.Brazilian Society of DermatologyPrivate Office in São PauloSão PauloBrazil

Personalised recommendations