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Stromal Cell Responses in Infection

  • Paul M. Kaye
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1060)

Abstract

Stromal cells and the immune functions that they regulate underpin multiple aspects of host defence, but the study of stromal cells as targets of infection and as regulators of anti-infective immunity is in its infancy and still limited to a few well-worked examples. In this review, the role of stromal cells at each sequential stage of infection is discussed, with examples drawn from across the spectrum of infectious agents, from prions to the parasitic helminths. Gaps in knowledge are identified, the challenges in studying stromal cell biology in the context of infection are highlighted, and the potential for stromal cell-targeted therapeutics is briefly discussed.

Keywords

Stromal infection Innate immunity TLOs Stromal architecture Stromal APCs Inflammation resolution 

Notes

Acknowledgements

The author thanks his numerous colleagues who have contributed to the study of stromal cell biology in his laboratory and the Medical Research Council and the Wellcome Trust for providing long-term research support. The author also apologizes to the many investigators whose work has been omitted for the sake of brevity but who have set the scene for future studies of the role of stromal cells in infection.

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Authors and Affiliations

  1. 1.Centre for Immunology and Infection, Department of Biology and Hull York Medical SchoolUniversity of YorkYorkUK

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