Vaginal Aplasia Creatsas Vaginoplasty

  • George Creatsas
Part of the Reproductive Medicine for Clinicians book series (REMECL, volume 1)


Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare congenital abnormality of the female genital tract. It is characterized by aplasia of the uterus and the upper two-thirds of the vagina.

The syndrome is caused by embryologic growth failure of the Mullerian ducts, with an incidence of almost one in 4000 female newborns.

Clinical examination, pelvic, and renal ultrasound as well as laparoscopy confirm the diagnosis of the syndrome.

Following the Creatsas vaginoplasty, a functioning vagina of 10–12 cm in depth and 5 cm in width is created in 95.5% of the cases. In addition, almost all cases declared themselves to have a satisfactory quality of sexual life, while less than 5% of the cases report an adequate one. Creatsas vaginoplasty is a simple, quick, and effective vulvo-perineoplasty for reconstruction of vaginal aplasia.


Creatsas vaginoplasty Vaginal aplasia Vaginal agenesis Vaginoplasty Colpoplasty Genital abnormalities 


  1. 1.
    Laggari V, Diareme S, Christogiorgos S, Deligeoroglou E, Christopoulos P, Tsiantis J, et al. Anxiety and depression in adolescents with polycystic ovary syndrome and Mayer-Rokitansky-Küster-Hauser syndrome. J Psychosom Obstet Gynaecol. 2009;30(2):83–8.CrossRefGoogle Scholar
  2. 2.
    Cai B, Zhang JR, Xi XW, Yan Q, Wan XP. Laparoscopically assisted sigmoid colon vaginoplasty in women with Mayer-Rokitansky-Kuster-Hauser syndrome: feasibility and short-term results. Br J Obstet Gynecol. 2007;114:1486–92.CrossRefGoogle Scholar
  3. 3.
    Capraro VJ, Gallego MB. Vaginal agenesis. Am J Obstet Gynecol. 1976;124:98–107.CrossRefGoogle Scholar
  4. 4.
    Creatsas G, Deligeorolgou E, Christopoulos P. Creation of a neovagina after Creatsas modification of Williams vaginoplasty for the treatment of 200 patients with Mayer- Rokitansky- Kuster- Hauser syndrome. Fertil Steril. 2010;94(5):1848–52.CrossRefGoogle Scholar
  5. 5.
    Creatsas G, Deligeoroglou E, Makrakis E, Kontoravdis A, Papadimitriou L. Creation of a neovagina following Williams vaginoplasty and the Creatsas modification in 111 patients with Mayer-Rokitansky-Küster-Hauser syndrome. Fertil Steril. 2001;76:1036–40.CrossRefGoogle Scholar
  6. 6.
    Deligeoroglou E, Christopoulos P, Creatsas G. A unique case of descending salpingitis and functioning endometrium in a Mullerian remnant in a woman with Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril. 2005;83:1547–8.CrossRefGoogle Scholar
  7. 7.
    Botsis D, Deligeoroglou E, Christopoulos P, Aravantinos L, Papagianni V, Creatsas G. Ultrasound imaging to evaluate Creatsas vaginoplasty. Int J Gynaecol Obstet. 2005;89:31–4.CrossRefGoogle Scholar
  8. 8.
    Deligeoroglou E, Kontoravdis A, Makrakis E, Christopoulos P, Kountouris A, Creatsas G. Development of leiomyomas on the uterine remnant of two women with Mayer-Rokitansky-Kuster-Hauser syndrome. Fertil Steril. 2004;81:1385–7.CrossRefGoogle Scholar
  9. 9.
    Fedele L, Bianchi S, Frontino G, Fontana E, Restelli E, Bruni V. The laparoscopic Vecchietti’s modified technique in Rokitansky syndrome: anatomic, functional, and sexual long-term results. Am J Obstet Gynecol. 2008;198(377):1–6.Google Scholar
  10. 10.
    Marques Hde S, dos Santos FL, Lopes-Costa PV, dos Santos AR, da Silva BB. Creation of a neovagina in patients with Rokitansky syndrome using peritoneum from the pouch of Douglas: an analysis of 48 cases. Fertil Steril. 2008;90:827–32.CrossRefGoogle Scholar

Copyright information

© IAHR (International Academy of Human Reproduction) 2018

Authors and Affiliations

  • George Creatsas
    • 1
  1. 1.Department of Obstetrics and GynecologyUniversity of AthensAthensGreece

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