Mifepristone for Postcoital Contraception
When in the early 1980s of the last century, Dr. Etienne-Emile Baulieu synthesized the first in the history—antiprogesterone—RU 486 or mifepristone, everybody considered it to be an “abortion pill” only. Beyond any doubt, it was a great achievement too, but the life has showed later that the new compound has not only this possibility but also the potential for solution of all problems, when progesterone is not needed.
- 1.von Hertzen H, et al. Lancet. Low dose mifepristone and two regimens of levonorgestrel for emergency contraception: a WHO multicentre randomized trial. 2002;360(9348):1803–10.Google Scholar
- 2.Trussell J, Raymond E, Cleland K. Emergency contraception: a last chance to prevent unwanted pregnancy. Princeton: Princeton University; 2016.Google Scholar
- 3.Wertheimer R. Emergency postcoital contraception. Am FamPhysician. 2000;62(10):2287–92.Google Scholar
- 7.Cheng L, Che Y, Gülmezglu AM. Interventions for emergency contraception. Cochrane Database Sys Rev. 2012;(8):CD001324.Google Scholar
- 10.United States Food and Drug Administration. FDA communication on levonorgestrel emergency contraceptive effectiveness and weight. Available at: http://www.fda.gov/Drugs/DrugsSafety/PostmarketDrugSafetyinformationforPatientaandProviders/ucm109775.htm. Accessed 24 May 2016.
- 14.Cameron ST, Berger C, Michie L, Klipping C, Gemzell-Danielsson K. The effects on ovarian activity of ulipristal acetate when ‘quickstarting’ a combined oral contraceptive pill: a prospective, randomized, double-blind parallel-arm, placebo-controlled study. Hum Reprod. 2015;30:1566–73.CrossRefGoogle Scholar