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Lethal Infections, Sepsis, and Shock

  • Reinhard B. Dettmeyer
Chapter

Abstract

A wide range of potentially fatal infections can be considered in cause-of-death investigations. In addition to common fatal infections, such as the various forms of pneumonia (viral pneumonia, purulent bronchopneumonia, lobar pneumonia), histopathological investigations can help to determine rare pneumonia pathogens (fungal pneumonia, Pneumocystis jirovecii infection, pulmonary tuberculosis, etc.). Other possible fatal infections include purulent pancreatitis, ascending cholangitis, clostridial infection, measles, echinococcosis, purulent ascending pyelonephritis, glomerulonephritis, and overwhelming postsplenectomy infection (OPSI) syndrome. Although histopathology often reveals nonspecific evidence of shock, it is also often able to identify the cause of shock. Fatal infections and sepsis can occur in conjunction with medical interventions (e.g., infected implants); however, signs of shock are also seen in anaphylactic shock, where attention needs to be paid as much to increased eosinophil granulocytes as to degranulated mast cells. Depending on the geographical region, pathogens such as leptospirosis and malaria can also be included in possible causes-of-death considerations.

References

  1. Albert S, Schröter A, Bratzke H, Brade V (1995) Postmortem diagnosis of falciparum malaria. Dtsch Med Wochenschr 120:18–22PubMedCrossRefGoogle Scholar
  2. An JL, Ishida Y, Kimura A, Tsokos M, Kondo T (2009) Immunohistochemical detection of CCR2 and CX3CR1 in sepsis-induced lung injury. Forensic Sci Int 192:e21–e25PubMedCrossRefGoogle Scholar
  3. Andes WA (1982) Spontaneous clostridial sepsis and sudden death. South Med J 75:378–379PubMedCrossRefGoogle Scholar
  4. Ansari MQ, Zamora JL, Lipscomb MF (1993) Postmortem diagnosis of acute anaphylaxis by serum tryptase analysis. Am J Clin Pathol 99:101–103PubMedCrossRefGoogle Scholar
  5. Barnard JH (1967) Allergic and pathologic findings in fifty insect-sting fatalities. J Allergy 40:107–114PubMedCrossRefGoogle Scholar
  6. Becker K, Ortmann C, Bajanowski T, Brinkmann B, Peters G (1999) Use of polymerase chain reaction for post-mortem diagnosis of malaria. Diagn Mol Pathol 8:211–215PubMedCrossRefGoogle Scholar
  7. Beh P, Byard RW (2015) Diptheria and lethal upper airway obstruction. Forensic Sci Med Pathol 11:133–135PubMedCrossRefGoogle Scholar
  8. Bennis A, Darif A, Mehadji BE, Chraibi N (2000) Cardiac hydatid cyst revealed by the complete heart block. Heart Vessel 15:46–48CrossRefGoogle Scholar
  9. Bisno AL (1971) Hyposplenism and overwhelming pneumococcal infection, a reappraisal. Am J Med Sci 262:101PubMedCrossRefGoogle Scholar
  10. Brandt G (1980) Pathohistologische Diagnostik der Gewebsformen einheimischer Mykosen. Pathologe 1:100–105PubMedGoogle Scholar
  11. Buris L, Szabó M, Kelemen J (1963) Hamman-Rich-Syndrom beim plötzlichen Tod. Dtsch Z Gesamte Gerichtl Med 54:211–216PubMedGoogle Scholar
  12. Burke MP, Opeskin K (1999) Nontraumatic clostridial myonecrosis. Am J Forensic Med Pathol 20:158–162PubMedCrossRefGoogle Scholar
  13. Butcovan D, Grigoriu C, Astărăstoae V (2010) Cardiac echinococcosis causing unexpected death. A case report. Rom J Leg Med 18:189–192CrossRefGoogle Scholar
  14. Byard RW (2009) An analysis of possible mechanisms of unexpected death occurring in hydatid disease (Echinococcosis). J Forensic Sci 54:919–922PubMedCrossRefGoogle Scholar
  15. Byard RW (2016) Gross and microscopic features of extensive subcutaneous emphysema. Forensic Sci Med Pathol 12:372–375PubMedCrossRefGoogle Scholar
  16. Carson HJ, Cook BA (2009) Mast cell tryptase in a case of anaphylaxis due to repeat antibiotic exposure. Legal Med 11:234–236PubMedCrossRefGoogle Scholar
  17. Clausnitzer H, Müntefering H (1975) Ein Fall von Goodpasture-Syndrom in der gerichtsärztlichen Praxis. Z Rechtsmed 76:245–251PubMedCrossRefGoogle Scholar
  18. Curti AJ, Lin JH, Szabo K (1985) Overwhelming post-splenectomy infection with Plesiomonas shigelloides in a patient cured of Hodgkin’s disease. Am J Clin Pathol 83:522–524PubMedCrossRefGoogle Scholar
  19. Da Broi U, Moreschi C (2011) Post-mortem diagnosis of anaphylaxis: a difficult task in forensic medizince. Forensic Sci Int 204:1–5CrossRefPubMedGoogle Scholar
  20. Dean HR (1922) Histology of a case of anaphylactic shock. J Pathol Bacteriol 25:305–315CrossRefGoogle Scholar
  21. De-Georgia F, Lodise M, Pascali VL, Spagnolo AG, d’Aloja E, Arena V (2015) An unusual case showing fatal rupture of a gastric ulcer or gastromalacia acida? The importance/role of histology for differential diagnosis. J Forensic Sci 60:240–242CrossRefGoogle Scholar
  22. Delage C, Irey NS (1972) Anaphylactic deaths. A clinicopathologic study of 43 cases. J Forensic Sci 17:525–540PubMedPubMedCentralCrossRefGoogle Scholar
  23. Delage C, Mullick FG, Irey NS (1973) Myocardial lesions in anaphylaxis. A histochemical study. Arch Pathol 95:185–189PubMedGoogle Scholar
  24. Dempers J, Sens MA, Wadee SA, Kinney HC, Odendaal HJ, Wright CA (2011) Progressive primary pulmonary tuberculosis presenting as the sudden unexpected death in infancy: a case report. Forensic Sci Int 206:e27–e30PubMedCrossRefGoogle Scholar
  25. Dettmeyer R (2006) Malaria tropica: Bericht zu einer Erkrankung mit tödlichem Ausgang. Robert Koch Institut. Epidemiologisches Bulletin, p 51Google Scholar
  26. Dettmeyer R, Varchmin-Schultheiß K, Madea B (1999) Postpartales letales OPSI-Syndrom bei posttraumatischer Splenosis peritonei. In: 8th spring-meeting of the German society of forensic medicine – northern region, Hamburg, 7–8 May 1999Google Scholar
  27. Diamond I (1958) The Hamman-Rich syndrome in childhood. Pediatrics 22:27Google Scholar
  28. Diamond LK (1969) Splenectomy in childhood and the hazard of overwhelming infection. Pediatrics 43:886–889PubMedGoogle Scholar
  29. Diaz T, Martinez T, Antepara I, Usandizaga JM, Lopez Valverde M, Jaurequi I (1996) Latex allergy as a risk during delivery. Br J Obstet Gynaecol 103:173–175PubMedCrossRefGoogle Scholar
  30. Dickerman JD (1979) Splenectomy and sepsis. Pediatrics 63:938–941PubMedGoogle Scholar
  31. Draisci G, Nucera E, Pollastrini E, Forte E, Zanfini B, Pinto R, Patriarca G, Schiavino D, Pietrini D (2007) Anaphylactic reactions during cesarean section. Int J Obstet Anesth 16:63–67PubMedCrossRefGoogle Scholar
  32. Edler C, Klein A, Gehl A, Ilchman C, Scherpe S, Schrot M (2011) The new influenza A (H1N1/09): symptoms, diagnostics, and autopsy results. Int J Legal Med 125:157–161PubMedCrossRefGoogle Scholar
  33. Edston E, van Hage-Hamsten M (1998) ß-Tryptase measurements post-mortem in anaphylactic deaths and in controls. Forensic Sci Int 93:135–142PubMedPubMedCentralCrossRefGoogle Scholar
  34. Edston E, van Hage-Hamsten M (2003) Death in anaphylaxis in a man with house dust mite allergy. Int J Legal Med 117:299–301PubMedCrossRefGoogle Scholar
  35. Edston E, van Hage-Hamsten M (2005) Postmortem diagnosis of anaphylaxis. In: Tsokos M (ed) Forensic pathology reviews, vol 3. Humana Press, Totowa, pp 267–281CrossRefGoogle Scholar
  36. Edston E (2013) Accumulation of eosinophils, mast cells, and basophils in the spleen in anaphylactic deaths. Forensic Sci Med Pathol 9:496–500PubMedCrossRefGoogle Scholar
  37. Fineschi V, Monasterolo G, Rosi R, Turillazzi E (1999) Fatal anaphylactic shock during a fluorescein angiography. Forensic Sci Int 100:137–142CrossRefPubMedGoogle Scholar
  38. Fracasso T, Jentgens L, Pfeiffer H, Sauerland C, Mangin P, Schmeling A (2016) Right heart ischemia in cases of sepsis. Forensic Sci Int 259:106–109PubMedCrossRefGoogle Scholar
  39. Gerber JE, Johnson JE, Scott MA, Madhusudhan KT (2002) Fatal meningitis and encephalitis due to bartonella henselae bacteria. J Forensic Sci 47:640–644PubMedGoogle Scholar
  40. Glenner GG, Cohen LA (1960) Histochemical demonstration of species-specific trypsin-like enzyme in mast cells. Nature 105:846–847CrossRefGoogle Scholar
  41. Goodpasture EW (1919) The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 158:863CrossRefGoogle Scholar
  42. Grinblat J, Gilboa A (1975) Overwhelming pneumococcal sepsis 25 years after splenectomy. Am J Med Sci 270:523PubMedCrossRefGoogle Scholar
  43. Hausmann R, Albert F, Geißdörfer W, Betz P (2004) Clostridium fallax associated with sudden death in a 16-year-old boy. J Med Microbiol 53:581–583PubMedCrossRefGoogle Scholar
  44. Heinze S, Erbersdobler A, Tsokos M (2010) Todesursache: anaphylaxie. Rechtsmedizin 20:282–284CrossRefGoogle Scholar
  45. Heinze S, Püschel K, Tsokos M (2011) Necrotizing fasciitis with fatal outcome: a report of two cases. Forensic Sci Med Pathol 7:278–282PubMedCrossRefGoogle Scholar
  46. Holdsworth RJ, Irving AD, Cuschieri A (1991) Postsplenectomy sepsis and its mortality rate. Actual versus perceived risks. Br J Surg 78:1031–1038PubMedCrossRefGoogle Scholar
  47. Ihama Y, Fukasawa M, Ninomiya K, Kawakami Y, Nagai T, Fuke C, Miyazaki T (2014) Anaphylactic shock caused by sting of crown-of-thorns starfish (Acanthaster planci). Forensic Sci Int 236:e5–e8PubMedCrossRefGoogle Scholar
  48. Jänisch S, Günther D, Fieguth A, Bange FC, Schmidt A, Debertin AS (2010) Postmortal detection of clostridia – putrefaction or infection? Arch Kriminol 225:99–108PubMedGoogle Scholar
  49. Janssen W (1977) Forensische histologie. Schmidt-Römhild, Lübeck, pp 189–216Google Scholar
  50. Johansson O, Virtanen M, Hilliges M, Yang Q (1992) Histamine immunohistochemistry: a new and highly sensitive method for studying cutaneous mast cells. Histochem J 24:283–287PubMedCrossRefGoogle Scholar
  51. Jorgensen P, Heiden M, Kern P, Schöneberg I, Krause G, Alpers K (2008) Underreporting of human alveolar echinococcosis, Germany. Emerg Infect Dis 14:935–937PubMedPubMedCentralCrossRefGoogle Scholar
  52. Kanthan R, Moyana T, Nyssen J (1999) Asplenia as a cause of sudden unexpected death in childhood. Am J Forensic Med Pathol 20:57–59PubMedCrossRefGoogle Scholar
  53. Kaplan M, Demirtas M, Cimen S, Ozler A (2001) Cardiac hydatid cyst with intracavitary expansion. Ann Thorac Surg 71:2034–2035CrossRefGoogle Scholar
  54. Kernbach-Wighton G, Böhnel H, Saternus KS (2003) Zur Phänomenologie beim positiven Clostridien-Nachweis. Rechtsmedizin 13:86–90CrossRefGoogle Scholar
  55. Kounis NG, Soufras GD, Kounis GN, Hahalis G (2013) Suicidal anaphylactic death: is Kounis anaphylaxis associated syndrome the cause? Forensic Sci Int 232:e42–e43PubMedCrossRefGoogle Scholar
  56. Kounis NG (2013) Coronary hypersensitivity disorder: the Kounis syndrome. Clin Ther 35:563–571PubMedCrossRefGoogle Scholar
  57. Kounis NG, Soufras GD, Hahalis G (2014) Accumulation of eosinophils, mast cells, and basophils in the spleen and the coronary arteries in anaphylactic deaths: is the Kounis hypersensitivity associated syndrome present? Forensic Sci Med Pathol 10:150–151PubMedCrossRefGoogle Scholar
  58. Kribben A, Uppenkamp A, Heeman U, Höffkes HG, Meusers P (1995) Postsplenektomie-sepsis (OPSI-Syndrom). Dtsch Med Wochenschr 120:771–775PubMedCrossRefGoogle Scholar
  59. Kucukarslan N, Savas Oz B, Demirkilic U, Tatar H (2005) An asymptomatic cardiac echinococcus cyst case. Int J Thor Cardiovasc Surg 74:37–42Google Scholar
  60. Kühn H, Kleinfeld F, Pfeifer B (1983) Über das Opsi-Syndrom. Pathologe 4:112–116PubMedGoogle Scholar
  61. Landi KK, Coleman T (2008) Sudden death in toddlers caused by influenza B infection: a report of two cases and a review of the literature. J Forensic Sci 53:213–215PubMedCrossRefGoogle Scholar
  62. Lau G (2005) Iatrogenic injury. A forensic perspective. In: Tsokos M (ed) Forensic pathology reviews, vol 3. Humana Press, Totowa, pp 351–439CrossRefGoogle Scholar
  63. Lau G, Lai SH (2008) Forensic histopathology. In: Tsokos M (ed) Forensic pathology reviews, vol 5. Humana Press, Totowa, pp 239–265CrossRefGoogle Scholar
  64. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS international sepsis definition conference. Crit Care Med 31:1250–1256PubMedCrossRefGoogle Scholar
  65. Lindblad BE, Lindblad LN (1990) Fatal pneumococcal bacteremia with disseminated intravascular coagulation and Waterhouse-Friderichsen syndrome in a vaccinated, splenectomized adult. Case report. Acta Chir Scand 156:487–488PubMedGoogle Scholar
  66. Locker GJ, Wagner A, Peter A, Staudinger T, Marosi C, Rintelen C, Knapp S, Malzer K, Weiss K, Metnitz P (1995) Lethal Waterhouse-Friderichsen syndrome in post-traumatic asplenia. J Trauma 39:784–786PubMedCrossRefGoogle Scholar
  67. Luchini D, Meacci F, Oggioni MR, Morabito G, D’Amato V, Gabrielli M, Pozzi G (2008) Molecular detection of Leptospira interrogans in human tissues and environmental samples in a lethal case of leptospirosis. Int J Legal Med 122:229–233PubMedPubMedCentralCrossRefGoogle Scholar
  68. Lunetta P, Penttila A, Salovaara R, Sajantila A (2002) Sudden death due to rupture of the arteria pancreatica magna: a complication of an immature pseudocyst in chronic pancreatitis. Int J Legal Med 116:43–46PubMedCrossRefGoogle Scholar
  69. Mahfoud B, Heinemann A, Püschel K (2002) Nekrotisierende Myositis durch Clostridium perfringens nach intravenöser Heroinapplikation. Rechtsmedizin 12:109–111CrossRefGoogle Scholar
  70. Mayer DE, Krauskopf A, Hemmer W, Moritz K, Jarisch R, Reiter C (2011) Usefulness of post mortem determination of serum tryptase, histamine and diamine oxidase in the diagnosis of fatal anaphylaxis. Forensic Sci Int 212:96–101PubMedCrossRefGoogle Scholar
  71. McCaughey WTE, Thomas BJ (1962) Pulmonary hemorrhage and glomerulonephritis. The relation of pulmonary hemorrhage to certain types of glomerular lesions. Am J Clin Pathol 38:577PubMedCrossRefGoogle Scholar
  72. Metter D, Schulz E (1977) Die forensische Begutachtung iatrogener Gasbrandinfektionen. Beitr Gerichtl Med 35:47–54PubMedGoogle Scholar
  73. Miyashita T, Kakimoto N, Ishida Y, Hayashi T, Kimura A, Tsokos M, Kondo T (2006) Immunohistochemical expression of tumor necrosis factor-α in sepsis-induced lung injury. Forensic Sci Med Pathol 2:103–108PubMedCrossRefGoogle Scholar
  74. Molz G, Hartmann HP, Griesser HR (1986) Generalisierte BCG-Infektion bei einem 7 Wochen alten, plötzlich verstorbenen Säugling. Pathologe 7:216–221PubMedGoogle Scholar
  75. Muciaccia B, Sestili C, de Grossi S, Vestri A, Cipolloni L, Cecchi R (2016) Are mast cells implicated in asphyxia? Int J Legal Med 130:153–161PubMedCrossRefGoogle Scholar
  76. Müller AM, Tsokos M (2006) Pathology of human endothelium in septic organ failure. In: Tsokos M (ed) Forensic pathology reviews, vol 4. Humana Press, Totowa, pp 161–192CrossRefGoogle Scholar
  77. Müller R, Korb G, Gedigk P (1970) Über zentrale Nekrosen in der Leber nach einem Schock. Verh Dtsch Ges Pathol 54:511PubMedGoogle Scholar
  78. Müller AM, Gruhn KM, Herwig MC, Tsokos M (2008) VE-cadherin and ACE: markers for sepsis in post mortem examination? Legal Med 10:257–263PubMedCrossRefGoogle Scholar
  79. Murphy TE, Kean BH, Venturini A, Lillehei CW (1971) Echinococcus cyst of the left ventricle: report of a case with review of the pertinent literature. J Thorac Cardiovasc Surg 61:443–450PubMedGoogle Scholar
  80. Naeve W (1971) Zum histologischen Nachweis einer akuten Malaria tropica an fäulnisveränderten Organen. Z Rechtsmed 69:210–216PubMedCrossRefGoogle Scholar
  81. Ondruschka B, Habeck JO, Hädrich C, Dreßler J, Bayer R (2015) Rare cause of natural death in forensic setting: hemophagocytic syndrome. Int J Legal Med 130:777–781.  https://doi.org/10.1007/s00414-015-1305-0 CrossRefPubMedGoogle Scholar
  82. Ortiz-Rey JA, Suárez-Peñaranda JM, San Miguel P, Muñoz JI, Rodríguez-Calvo MS, Concheiro L (2008) Immunohistochemical analysis of P-Selectin as a possible marker of vitality in human cutaneous wounds. J Forensic Legal Med 15:368–372CrossRefGoogle Scholar
  83. Ortmann C, Brinkmann B (1997) The expression of P-selectin in inflammatory and non-inflammatory lung tissue. Int J Legal Med 110:155–158PubMedCrossRefGoogle Scholar
  84. Ortmann C, Pfeiffer H, Brinkmann B (2000) Demonstration of myocardial necrosis in the presence of advanced putrefaction. Int J Legal Med 114:50–55CrossRefPubMedGoogle Scholar
  85. Osawa M, Satoh F, Horiuchi H et al (2008) Postmortem diagnosis of fatal anaphylaxis during intravenous administration of therapeutic and diagnostic agents: evaluation of clinical laboratory parameters and immunohistochemistry in three cases. Legal Med 10:143–147CrossRefPubMedGoogle Scholar
  86. Pavelites JJ, Prahlow JA (2011) Fatal human monocytic ehrlichiosis: a case study. Forensic Sci Med Pathol 7:287–293PubMedCrossRefGoogle Scholar
  87. Peabody JW, Buechner HH, Anderson HE (1955) Hamman-Rich syndrome. Arch Intern Med 43:1127Google Scholar
  88. Perskvist N, Edston E (2007) Differential accumulation of pulmonary and cardiac mast-cell-subsets and eosinophils between fatal anaphylaxis and asthma death: a postmortem comparative study. Forensic Sci Int 169:43–49CrossRefPubMedGoogle Scholar
  89. Plenzig S, Döring C, Held H, Verhoff MA (2016) On the wrong track. Death of a drug abuser in a penitentiary due to desquamative interstitial pneumonia. Rechtsmedizin 26:440–443CrossRefGoogle Scholar
  90. Popper HH, Pailer S, Wurzinger G, Feldner H, Hesse C, Eber E (2002) Expression of adhesion molecules in allergic lung diseases. Virchows Arch 440:172–180PubMedCrossRefGoogle Scholar
  91. Prahlow JA, Barnard JJ (1998) Fatal anaphylaxis due to fire and stings. Am J Forensic Med Pathol 19:137–142PubMedCrossRefGoogle Scholar
  92. Preuss J, Dettmeyer R, Strehler M, Madea B (2006a) Unerkannt akut-letale Infektionen. Ursachen plötzlicher Todesfälle im Erwachsenenalter. Rechtsmedizin 16:165–171CrossRefGoogle Scholar
  93. Preuss J, Dettmeyer R, Madea B (2006b) Tödlich verlaufende, postoperative Peritonitiden. Rechtsmedizinische Begutachtung. Rechtsmedizin 16:383–388CrossRefGoogle Scholar
  94. Pumphrey RSH, Roberts ISD (2000) Postmortem findings after fatal anaphylactic reactions. J Clin Pathol 53:273–276PubMedPubMedCentralCrossRefGoogle Scholar
  95. Püschel K, Lockemann U, Dietrich M (1998) Recurrent fatal outcome of malaria infections due to late diagnosis. Dtsch Ärztebl 95:2697–2700Google Scholar
  96. Ramsay LE, Bouskill KC (1973) Fatal pneumococcal meningitis in adults following splenectomy: two case reports and a review of the literature. J R Nav Med Serv 59:102–114PubMedGoogle Scholar
  97. Ramsthaler F, Verhoff MA, Gehl A, Kettner M (2010) The novel H1N1/swine-origin influenza virus and its implications for autopsy practice. Int J Legal Med 124:171–173PubMedCrossRefGoogle Scholar
  98. Randall B, Butts J, Halsey JF (1995) Elevated post-mortem tryptase in the absence of anaphylaxis. J Forensic Sci 40:208–211PubMedCrossRefGoogle Scholar
  99. Rauch E, Tutsch-Bauer E, Penning R (1999) Malaria tropica – a problem in forensic medicine? Rechtsmedizin 10:1–6CrossRefGoogle Scholar
  100. Reavy DT, Nakonechny D (1979) Sudden death and sepsis after splenectomy. J Forensic Sci 24:757–761Google Scholar
  101. Reggiani Bonetti L, Maccio L, Trani N, Radheshi E, Palmiere C (2015) Splenic hypereosinophilia in anaphylaxis-related death: different assessments depending on different types of allergens? Int J Legal Med 129:97–103PubMedCrossRefGoogle Scholar
  102. Rimmer EF, Turberville C, Horton MA (1984) Human mast cells detected by monoclonal antibodies. J Clin Pathol 37:1249–1255PubMedPubMedCentralCrossRefGoogle Scholar
  103. Risse M, Verhoff MA, Lehmann H, Dettmeyer R (2008) Unerkannte letale Maserninfektion bei einem 14-jährigen Mädchen mit Trisomie 21. Rechtsmedizin 18:383–386CrossRefGoogle Scholar
  104. Rizzo M, Magro G, Castaldo P (2004) OPSI (overwhelming postsplenectomy infection) syndrome: a case report. Forensic Sci Int 164S:S55–S56CrossRefGoogle Scholar
  105. Rodriguez Gomez M, Oehler U, Helpap B (1997) Foudroyant verlaufende Sepsis nach Splenektomie. Pathologe 18:257–260PubMedCrossRefGoogle Scholar
  106. Roncati L, Barbolini G, Scacchetti AT, Busani S, Maiorana A (2013) Unexpected death: anaphylactic intraoperative death due to Thymoglobulin carbohydrate excipient. Forensic Sci Int 228:e28–e32PubMedCrossRefGoogle Scholar
  107. Ruf G, Kirchner R, Lausen M, Pelz K (1986) Die Clostridieninfektion der Galle. Chir Praxis 36:13–22Google Scholar
  108. Sampson HA (2000) Food anaphylaxis. Br Med Bull 56:925–935PubMedCrossRefGoogle Scholar
  109. Sasaki T, Nanjo H, Takahashi M, Sugijama T, Ono I, Masuda H (2000) Non-traumatic gas gangrene in the abdomen: report of six autopsy cases. Gastroenterology 35:382–390Google Scholar
  110. Schumaker B Jr (1952) Splenic studies: I. Susceptibility to infection after splenectomy performed in infancy. Am Surg 136:239Google Scholar
  111. Seufert RM, Böttcher W (1982) Organerhaltende Behandlung von Milzverletzungen. Dtsch Med Wochenschr 107:523–526PubMedCrossRefGoogle Scholar
  112. Shen Y, Li L, Grant J et al (2009) Anaphylactic deaths in Maryland (United States) and Shanghai (China): a review of forensic autopsy cases from 2004 to 2006. Forensic Sci Int 186:1–5PubMedCrossRefGoogle Scholar
  113. Shintaku M, Sangawa A, Yonezawa A, Nasu K (2001) Aortic lesions in aspergillosis: histopathological study of two autopsy cases. Virchows Arch 439:640–644PubMedCrossRefGoogle Scholar
  114. Simini B (1999) Liposuction surgery in Italy leads to Streptococcus pyogenes sepsis. Lancet 353:1164CrossRefGoogle Scholar
  115. Siveke J, Caselitz J, Püschel K (2001) Clinical and morphologic features of fatal falciparum malaria. Rechtsmedizin 11:82–88CrossRefGoogle Scholar
  116. Soper DE (1986) Clostridial myonecrosis arising from an episiotomy. Obstet Gynecol 68(3 Suppl):26S–28SPubMedGoogle Scholar
  117. Sterzig V, Wild V, Weishaupt J, Tatschner T, Babel B, Bohnert M (2016) Tod beim Hausarzt. Arch Kriminol 238:120–127Google Scholar
  118. Suzuki H, Murata K, Sakamoto A (2009) An autopsy case of fulminant sepsis due to pneumatosis cystoides intestinalis. Legal Med 11:S528–S530PubMedCrossRefGoogle Scholar
  119. Telli HH, Durgut K (2001) Ruptured cardiac hydatid cyst masquerading as acute coronary syndrome: report of a case. Surg Today 31:908–911PubMedCrossRefGoogle Scholar
  120. Thierauf A, Dettmeyer R, Wollersen H, Musshoff F, Madea B (2007) Fatal Candida tropicalis infection in an 8-month-old infant with an aplasia of the thymus as a rare cause of death in infancy. Forensic Sci Int 169:228–233PubMedCrossRefGoogle Scholar
  121. Thu M, Winskong C, Byard RW (2014) Tuberculosis and sudden death. Forensic Sci Med Pathol 10:266–268PubMedCrossRefGoogle Scholar
  122. Trani N, Reggiani Bonetti LR, Gualandri G, Barbolini G (2008) Immediate anaphylactic death following antibiotics injection: splenic eosinophilia easily revealed by pagoda red stain. Forensic Sci Int 181:21–25CrossRefPubMedGoogle Scholar
  123. Tsokos M (2012) Syphilitic aortic aneurysm rupture as cause of sudden death. Forensic Sci Med Pathol 8:325–326PubMedCrossRefGoogle Scholar
  124. Tsokos M (2003) Immunohistochemical detection of sepsis-induced lung injury in human autopsy material. Legal Med 5:73–86PubMedCrossRefGoogle Scholar
  125. Tsokos M (2004) Fatal respiratory tract infections with Mycoplasma pneumoniae. Histopathological features, aspects of post-mortem diagnosis and medicolegal implications. In: Tsokos M (ed) Forensic pathology reviews, vol 1. Humana Press, Totowa, pp 201–218CrossRefGoogle Scholar
  126. Tsokos M (2005) Pathology of sepsis. In: Rutty GN (ed) Essentials of autopsy practice, vol 3. Springer, London, pp 39–85Google Scholar
  127. Tsokos M (2006a) Postmortale Sepsisdiagnostik. Teil 1: Pathomorphologie. Rechtsmedizin 16:231–246CrossRefGoogle Scholar
  128. Tsokos M (2006b) Postmortale Sepsisdiagnostik. Teil 2: Immunhistochemie und biochemische Diagnostik. Rechtsmedizin 16:333–342CrossRefGoogle Scholar
  129. Tsokos M, Braun C (2007) Acute pancreatitis presenting as sudden, unexpected death: an autopsy-based study of 27 cases. Am J Forensic Med Pathol 28:267–270PubMedCrossRefGoogle Scholar
  130. Tsokos M, Fehlauer F (2001) Post-mortem markers of sepsis: an immunohistochemical study using VLA-4 (CD49d/CD29) and ICAM-1 (CD54) for the detection of sepsis-induced lung injury. Int J Legal Med 114:291–294PubMedCrossRefGoogle Scholar
  131. Tsokos M, Püschel K (1999) Iatrogenic staphylococcus aureus septicaemia following intravenous and intramuscular injections: clinical course and pathomorphological findings. Int J Legal Med 112:303–308PubMedCrossRefGoogle Scholar
  132. Tsokos M, Fehlauer F, Püschel K (2000) Immunohistochemical expression of E-selectin in sepsis-induced lung injury. Int J Legal Med 113:338–342PubMedCrossRefGoogle Scholar
  133. Tsokos M, Reichelt U, Jung R, Nierhaus A, Püschel K (2001) Interleukin-6 and C-reactive protein serum levels in sepsis-related fatalities during the early post-mortem period. Forensic Sci Int 119:47–56PubMedCrossRefGoogle Scholar
  134. Tsokos M, Anders S, Paulsen F (2002) Lectin binding patterns of alveolar epithelium and subepithelial seromucous glands of the bronchi in sepsis and controls – an approach to characterize the non-specific immunological response of the human lung to sepsis. Virchows Arch 440:181–186PubMedCrossRefGoogle Scholar
  135. Tsokos M, Pufe T, Paulsen F, Anders S, Mentlein R (2003) Pulmonary expression of vascular endothelial growth factor in sepsis. Arch Pathol Lab Med 127:331–335PubMedGoogle Scholar
  136. Tsokos M, Zöllner B, Feucht HH (2005) Fatal influenza A infection with Staphylococcus aureus superinfection in a 49-year-old woman presenting as sudden death. Int J Legal Med 119:40–43PubMedCrossRefGoogle Scholar
  137. Tsokos M, Schalinski S, Paulsen F, Sperhake JP, Püschel K, Sobottka I (2008) Pathology of fatal traumatic and nontraumatic clostridial gas gangrene: a histopathological, immunohistochemical, and ultrastructural study of six autopsy cases. Int J Legal Med 122:35–41PubMedCrossRefGoogle Scholar
  138. Tümer AR, Dener C (2007) Diagnostic dilemma of sudden deaths due to acute hemorrhagic pancreatitis. J Forensic Sci 52:180–182PubMedCrossRefGoogle Scholar
  139. Turillazzi E, Di Donato S, Neri M, Riezzo I, Fineschi V (2007) An immunohistochemical study in a fatal case of acute interstitial pneumonitis (Hamman-Rich syndrome) in a 15-year-old boy presenting as sudden death. Forensic Sci Int 173:73–77PubMedCrossRefGoogle Scholar
  140. Turillazzi E, Greco P, Neri M, Pomara C, Riezo I, Fineschi V (2008) Anaphylactic latex reaction during anaesthesia: the silent culprit in a fatal case. Forensic Sci Int 179:e5–e8PubMedCrossRefGoogle Scholar
  141. Unkrig S, Hagemeier L, Madea B (2010) Postmortem diagnosis of assumed food anaphylaxis in an unexpected death. Forensic Sci Int 198:e1–e4PubMedPubMedCentralCrossRefGoogle Scholar
  142. Urata Y, Hasegawa M, Hasegawa H, Shikano M, Kawashima S, Imoto M (1997) A fatal case of overwhelming postsplenectomy infection syndrome developing 10 years after splenectomy. Nihon Rinsho Meneki Gakkai Kaishi 20:184–190PubMedCrossRefGoogle Scholar
  143. van Wyck DB, Witte MH, Witte CL, Thies AC (1980) Critical splenic mass for survival from experimental pneumococcemia. J Surg Res 28:14–17PubMedCrossRefGoogle Scholar
  144. Vance BM, Strassmann G (1941) Sudden death following injection of foreign protein. Arch Pathol 34:849–865Google Scholar
  145. Walls AF, Bennett AR, McBride HM, Glennie MJ, Holgate ST, Church MK (1990a) Production and characterization of monoclonal antibodies specific for human mast cell tryptase. Clin Exp Allergy 20:581–589PubMedCrossRefGoogle Scholar
  146. Walls AF, Jones DB, Williams JH, Church MK, Holgate ST (1990b) Immunohistochemical identification of mast cells in formaldehyde-fixed tissue using monoclonal antibodies specific for tryptase. J Pathol 162:119–126PubMedCrossRefGoogle Scholar
  147. Weis A, Bohnert M (2008) Expression patterns of adhesion molecules P-selectin, von Willebrand factor and PECAM-1 in lungs: a comparative study in cases of burn shock and hemorrhagic shock. Forensic Sci Int 175:102–106PubMedPubMedCentralCrossRefGoogle Scholar
  148. White RB, Craighead JT (1957) Hamman-Rich syndrome. Dis Chest 31:335PubMedCrossRefGoogle Scholar
  149. Worm M, Eckermann O, Dölle S, Aberer W, Beyer K, Hawranek T, Hompes S, Koehli A, Mahler V, Nemat K, Niggemann B, Pföhler C, Rabe U, Reissig A, Rietschel E, Scherer K, Treudler R, Ruëff F (2014) Triggers and treatment of anaphylaxis: an analysis of 4000 cases from Germany, Austria and Switzerland. Dtsch Ärztebl Int 111:367–375PubMedPubMedCentralGoogle Scholar
  150. Yagmur G, Kara E, Yildirim M, Gurler AS, Eken AE, Babur C (2015) Two cases of malaria due to Plasmodium falciparum resulting in death: postmortem identification. Rom J Leg Med 23:33–36CrossRefGoogle Scholar
  151. Young RC, Bennett JE, Vogel CL, Carbone PP, DeVita VT (1970) Aspergillosis. The spectrum of the disease in 98 patients. Medicine 49:147–173PubMedCrossRefGoogle Scholar
  152. Yunginger JW, Nelson DR, Squillace DL et al (1991) Laboratory investigation of deaths due to anaphylaxis. J Forensic Sci 36:857–865PubMedPubMedCentralCrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Reinhard B. Dettmeyer
    • 1
  1. 1.University Hospital Giessen Institute of Forensic MedicineGiessenGermany

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