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Gendered Innovation in Health and Medicine

  • Londa Schiebinger
  • Ineke Klinge
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1065)

Abstract

Excellence in research requires careful attention to sex and gender analysis. The Gendered Innovations project, initiated in 2009, develops state-of-the-art methods of sex and gender analysis for basic and applied research. This chapter reviews recent developments in cardiovascular disease for (1) analyzing sex, (2) analyzing gender, and (3) policy initiatives.

Keywords

Gender medicine Gendered innovations Innovation in health Cardiovascular disease Matera Alliance Biomedical research Policy Sex Gender Intersex Drug development Biomedical devices 

References

  1. 1.
    United States General Accounting Office. Drug safety: most drugs withdrawn in recent years had greater health risks for women. Washington, DC: Government Publishing Office; 2001.Google Scholar
  2. 2.
    Roth J, Etzioni R, Waters T, Pettinger M, Rossouw J, Anderson G, Chlebowski R, Manson J, Hlatky M, Johnson K. Economic return from the women’s health initiative Estrogen Plus Progestin clinical trial: a modeling study. Ann Intern Med. 2014;160(9):594–602.CrossRefPubMedPubMedCentralGoogle Scholar
  3. 3.
    Cornelison TL, Clayton J. Considering sex as a biological variable in biomedical research. Gend Genome. 2017; 1(2):89–93; Clayton J. Studying both sexes: a guiding principle for biomedicine. FASEB J. 2015;30:1–6.Google Scholar
  4. 4.
    Collins FS, Tabak LA. Policy: NIH plans to enhance reproducibility. Nature. 2014;505:612–3.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Schiebinger L. Has Feminism changed science? Cambridge, MA: Harvard University press; 1999.Google Scholar
  6. 6.
    Schiebinger L, Klinge I. Gendered Innovation in Health and Medicine. Gender: Zeitschrift für Geschlecht, Kultur, und Gesellschaft. 2015;2(2015):29–50.CrossRefGoogle Scholar
  7. 7.
    European Commission. Fact sheet: gender equality in Horizon 2020. Brussels; 2013 December 9; European Commission. Vademecum on gender equality in Horizon 2020. Brussels: RTD-B7 Science with and for Society; 2016.Google Scholar
  8. 8.
    European Commission. European Commission. Horizon 2020. Monitoring Report 2015. Directorate-General for Research and Innovation. Brussels: European Commission, 53; 2016.Google Scholar
  9. 9.
    Canadian Institutes of Health Research (CIHR). Gender, sex and health research guide: a tool for CIHR applicants. Ottawa: Canadian Institutes of Health Research (CIHR); 2012. Enacted December 2010Google Scholar
  10. 10.
    Clayton J, Collins F. NIH to balance sex in cell and animal studies. Nature. 2014;509:282–3; Clayton JA. Studying both sexes: a guiding principle for biomedicine. FASEB J. 2016;30(2):519–24; Tannenbaum C, Schwarz JM, Clayton JA, de Vries GJ, Sullivan C. Evaluating sex as a biological variable in preclinical research: the devil in the details. Biol Sex Diff. 2016;7(1):13.Google Scholar
  11. 11.
    Schiebinger L, Schraudner M. Interdisciplinary approaches to achieving gendered innovations in science, medicine, and engineering1. Interdiscip Sci Rev. 2011;36(2):154–67.CrossRefGoogle Scholar
  12. 12.
  13. 13.
    Schiebinger L, Klinge I. Gendered innovations: how gender analysis contributes to research. Luxembourg: Publications Office of the European Union, Foreword by EC Commissioner for Research, Innovation, and Science, Máire Geoghegan-Quinn; 2013Google Scholar
  14. 14.
    Schiebinger L, Klinge I, Paik HY, Sánchez de Madariaga I, Schraudner M, Stefanick M (eds). Gendered innovations in science, health & medicine, engineering, and environment; 2011–2017. genderedinnovations.stanford.edu.
  15. 15.
    Ristvedt SL. The evolution of gender. JAMA Psychiatry. 2014;71(1):13–14. Oertelt-Prigione S, Parol R, Krohn S, Preißner R, Regitz-Zagrosek V. Analysis of sex and gender-specific research reveals a common increase in publications and marked differences between disciplines. BMC Med. 2010;8(1):1.Google Scholar
  16. 16.
  17. 17.
    Oertelt-Prigione S, Regitz-Zagrosek V (eds). Sex and gender aspects in clinical medicine. London: Springer; 2012; Regitz-Zagrosek V (ed). Sex and gender differences in pharmacology. London: Springer; 2012; Schenck-Gustafsson K, DeCola P, Pfaff D, Pisetsky D (eds). Handbook of clinical gender medicine. Basel: Karger; 2012.Google Scholar
  18. 18.
    Bairey Merz C, Mark S, Boyan B, Jacoba A, Shah P, Shaw L, Taylor D, Marbán E. Proceedings from the scientific symposium: sex differences in cardiovascular disease and implications for therapies. J Women’s Health. 2010;19(6):1059–72.CrossRefGoogle Scholar
  19. 19.
    Bugiardini R, Bairey Merz C. Angina with “normal” coronary arteries: a changing philosophy. J Am Med Assoc. 2005;293(4):477–84.CrossRefGoogle Scholar
  20. 20.
    Robinson J, Wallace R, Limacher M, Ren H, Cochrane B, Wassertheil-Smoller S, Ockene J, Blanchette P, Ko M. Cardiovascular risk in women with non-specific chest pain (from the women’s health initiative hormone Trials). Am J Cardiol. 2008;102(6):693–9.CrossRefPubMedGoogle Scholar
  21. 21.
    GenCAD Partners. Gender in coronary artery disease. Brussels.: European Union; 2017.Google Scholar
  22. 22.
    Pelletier R, Ditto B, Pilote L. A composite measure of gender and its association with risk factors in patients with premature acute coronary syndrome. Psychosom Med. 2015;77(5):517–26. See also Schiebinger L, Stefanick ML. Gender matters in biological research and medical practice; 2016.CrossRefPubMedGoogle Scholar
  23. 23.
    Bem SL. The measurement of psychological androgyny. J Consult Clin Psychol. 1974;42:155–62.CrossRefPubMedGoogle Scholar
  24. 24.
    Bekker MHJ. Investigating gender within health research is more than sex disaggregation of data: a multi-facet gender and health model. Psychol Health Med. 2003;8(2):231–43; Nowatzki N, Grant KR. Sex is not enough: the need for gender-based analysis in health research. Health Care Women Int. 2011;32(4):263–77.Google Scholar
  25. 25.
    Nielsen M, Brooks C Cullen M, Einstein G, Ioannidis J, Klinge I, LeBlanc H, Neilands T, Paik H, Peragine D, Pilote L, Prochaska J, Ristvedt S, Stefanick M, Schiebinger L. Gender variables in health research; in progress.Google Scholar
  26. 26.
  27. 27.
    Tannenbaum C, Day D. Age and sex in drug development and testing for adults. Pharmacol Res. 2017;121:83–93.CrossRefPubMedGoogle Scholar
  28. 28.
    http://ec.europa.eu/transparency/regexpert/index.cfm?do=groupDetail.groupDetailDoc&id=28824&no=1 AGG position paper 2016: For a better integration of the gender dimension in the Horizon 2020 Work Programme 2018-2020.
  29. 29.
  30. 30.
  31. 31.
  32. 32.
  33. 33.
    Ludwig S, et al. A successful strategy to integrate sex and gender medicine into a newly developed medical curriculum. J Women's Health. 2015;24(12):996–1005.CrossRefGoogle Scholar
  34. 34.

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.History of ScienceStanford UniversityStanfordUSA
  2. 2.Horizon 2020 Advisory Group for Gender, European CommissionBrusselsBelgium

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