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Different Tumor Microenvironments Lead to Different Metabolic Phenotypes

  • Marjorie Justine Antonio
  • Anne Le
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1063)

Abstract

The beginning of the twenty-first century offered new advances in cancer research, including the expansion of the knowledge about the tumor microenvironment (TME). Because TMEs provide the niches in which cancer cells, fibroblast, lymphocyte, and immune cells reside, they play a key role in cancer cell development, differentiation, survival, and proliferation. Throughout cancer progression, the TME constantly evolves, causing cancer cells to adapt to the new conditions. The heterogeneity of cancer, evidenced by diverse proliferation rates, cellular structure, metabolism, and gene expression, presents challenges for cancer treatments despite the advances in research. This chapter discusses how different tumor microenvironments lead to specific metabolic adaptations which drive cancer progression.

Keywords

Tumor microenvironments Metabolic phenotypes Fatty acid oxidation Metabolic processes Heterogeneity of cancer 

Abbreviations

α-KG

α-ketoglutarate

ACC

Acetyl-CoA carboxylase

AMPK

AMP-activated protein kinase

ATP

Adenosine triphosphate

CAF

Cancer-associated fibroblasts

Cav-1

Caveolin-1

ETC

Electron transport chain

FABP4

Fatty acid-binding protein 4

FASN

Fatty acid synthase

HBx

Hepatitis B virus X protein

HCC

Hepatocellular carcinoma

hMSCs

Human mesenchymal stem cells

KRAS

Kirsten rat sarcoma viral oncogene homolog

NADPH

Nicotinamide adenine dinucleotide phosphate

SCD1

Stearoyl-CoA desaturase 1

TME

Tumor microenvironment

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyJohns Hopkins University School of MedicineBaltimoreUSA
  2. 2.Department of Pathology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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