Glucose Metabolism in Cancer

  • Sminu Bose
  • Anne LeEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1063)


Otto Warburg observed a peculiar phenomenon in 1924, unknowingly laying the foundation for the field of cancer metabolism. While his contemporaries hypothesized that tumor cells derived the energy required for uncontrolled replication from proteolysis and lipolysis, Warburg instead found them to rapidly consume glucose, converting it to lactate [1]. The significance of this finding, later termed the Warburg effect, went unnoticed by the larger scientific community at that time. The field of cancer metabolism lay dormant for almost a century awaiting advances in molecular biology and genetics which would later open the doors to new cancer therapies.


Glucose metabolism Warburg effect Glycogenolysis Gluconeogenesis Cancer metabolism 





Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase


Also known as PKB, protein kinase B


Adenosine triphosphate








3-Dihydroxy-6-methyl-7-phenylmethyl-4-propylnaphthalene-1-carboxylic acid






1,4-Alpha-glucan branching enzyme


Glucose transporter


Glycogen synthase kinase 2


Glycogen synthase 1


Hypoxia-inducible factor 1α


Hexokinase 2


Lactate dehydrogenase A


Mechanistic target of rapamycin


Nicotinamide adenine dinucleotide


Phosphoenolpyruvate carboxykinase 2


Phosphoenolpyruvate carboxykinase 1




6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3




Phosphoinositide 3-kinase


Pentose phosphate pathway


Protein phosphatase 1 regulatory subunit 3C


Tricarboxylic acid


TP53-induced glycolysis and apoptosis regulator


Tumor protein 53


UTP:glucose-1-P uridylyltransferase 2


Von Hippel-Lindau


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of MedicineColumbia University Medical CenterNew YorkUSA
  2. 2.Department of Pathology and OncologyJohns Hopkins University School of MedicineBaltimoreUSA

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