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The Modifiable Scaffold for Tissue Engineering

  • Kieran L. Hudson
Chapter
Part of the Springer Theses book series (Springer Theses)

Abstract

The scaffold chosen for investigating the application of carbohydrate-based modifiers for tissue engineering was the hSAF system previously developed in the Woolfson lab (Sect.  1.4.2) (Banwell et al., Nat Mater 8:596–600, 2009, [1]). Hydrogels are made by mixing two synthetic peptides, hSAF-p1 and hSAF-p2 (Table 4.1), that form heterodimeric coiled coils (Fig.  1.13). These heterodimers have a designed slipped interface, leading to longitudinal assembly into fibres that entangle to form the gel (Fig.  1.12).

References

  1. 1.
    Banwell EF, Abelardo ES, Adams DJ, Birchall MA, Corrigan A, Donald AM, Kirkland M, Serpell LC, Butler MF, Woolfson DN (2009) Nat Mater 8:596–600CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Fields GB, Noble RL (1990) Int J Pept Protein Res 35:161–214CrossRefPubMedGoogle Scholar
  3. 3.
    Fletcher JM, Boyle AL, Bruning M, Bartlett GJ, Vincent TL, Zaccai NR, Armstrong CT, Bromley EHC, Booth PJ, Brady RL, Thomson AR, Woolfson DN (2012) ACS Synth Biol 1:240–250CrossRefPubMedGoogle Scholar
  4. 4.
    Burgess NC, Sharp TH, Thomas F, Wood CW, Thomson AR, Zaccai N, Brady RL, Serpell LC, Woolfson DN (2015) J Am Chem Soc 137:10554–10562CrossRefPubMedGoogle Scholar
  5. 5.
    Wasmuth A, Mehrban N, Hudson KL, Thomson AR, Mullen LM, Birchall MA, Woolfson DN Manuscript in preparationGoogle Scholar
  6. 6.
    Mehrban N, Abelardo ES, Wasmuth A, Hudson KL, Mullen LM, Thomson AR, Birchall MA, Woolfson DN (2014) Adv Healthc Mater 3:1387–1391CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Discher DE, Mooney DJ, Zandstra PW (2009) Science 324:1673–1677CrossRefPubMedPubMedCentralGoogle Scholar
  8. 8.
    Bromley EHC, Channon KJ, King PJS, Mahmoud ZN, Banwell EF, Butler MF, Crump MP, Dafforn TR, Hicks MR, Hirst JD, Rodger A, Woolfson DN (2010) Biophys J 98:1668–1676CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Chen Y-H, Yang JT, Chau KH (1974) Biochemistry 13:3350–3359CrossRefPubMedGoogle Scholar
  10. 10.
    Pandya MJ, Spooner GM, Sunde M, Thorpe JR, Rodger A, Woolfson DN (2000) Biochemistry 39:8728–8734CrossRefGoogle Scholar
  11. 11.
    De Carlo S, Harris JR (2011) Micron 42:117–131CrossRefPubMedGoogle Scholar
  12. 12.
    Sharp TH, Bruning M, Mantell J, Sessions RB, Thomson AR, Zaccai NR, Brady RL, Verkade P, Woolfson DN (2012) Proc Natl Acad Sci USA 109:13266–13271Google Scholar
  13. 13.
    Yan C, Pochan DJ (2010) Chem Soc Rev 39:3528–3540CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Rostovtsev VV, Green LG, Fokin VV, Sharpless KB (2002) Angew Chem Int Ed 41:2596–2599CrossRefGoogle Scholar
  15. 15.
    Mahmoud ZN, Gunnoo SB, Thomson AR, Fletcher JM, Woolfson DN (2011) Biomaterials 32:3712–3720CrossRefPubMedGoogle Scholar
  16. 16.
    Worrell BT, Malik JA, Fokin VV (2013) Science 340:457–460CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Hersel U, Dahmen C, Kessler H (2003) Biomaterials 24:4385–4415CrossRefPubMedGoogle Scholar
  18. 18.
    Perlin L, MacNeil S, Rimmer S (2008) Soft Matter 4:2331–2349CrossRefGoogle Scholar
  19. 19.
    Greene LA, Tischler AS (1976) Proc Natl Acad Sci USA 73:2424–2428CrossRefPubMedGoogle Scholar
  20. 20.
    Chan TR, Stahl PJ, Yu SM (2011) Adv Funct Mater 21:4252–4262CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Mehrban N, Zhu B, Tamagnini F, Young FI, Wasmuth A, Hudson KL, Thomson AR, Birchall MA, Randall AD, Song B, Woolfson DN (2015) ACS Biomater Sci Eng 1:431–439CrossRefPubMedPubMedCentralGoogle Scholar
  22. 22.
    Price JL, Powers ET, Kelly JW (2011) ACS Chem Biol 6:1188–1192CrossRefPubMedPubMedCentralGoogle Scholar
  23. 23.
    Aggeli A, Nyrkova IA, Bell M, Harding R, Carrick L, Mcleish TCB, Semenov AN, Boden N (2001) Proc Natl Acad Sci USA 98:11857–11862CrossRefPubMedGoogle Scholar
  24. 24.
    Ushiki T (2002) Arch Hist Cytol 62:109–126CrossRefGoogle Scholar
  25. 25.
    Gaetke LM, Chow CK (2003) Toxicology 189:147–163CrossRefPubMedGoogle Scholar
  26. 26.
    Schilsky ML, Blank RR, Czaja MJ, Zern MA, Scheinberg IH, Stockert RJ, Sternlieb I (1989) J Clin Invest 84:1562–1568CrossRefPubMedPubMedCentralGoogle Scholar
  27. 27.
    Brenner AJ, Harris ED (1995) Anal Biochem 226:80–84CrossRefPubMedGoogle Scholar
  28. 28.
    Baker EG, Bartlett GJ, Crump MP, Sessions RB, Linden N, Faul CFJ, Woolfson DN (2015) Nat Chem Biol 11:221–228CrossRefPubMedPubMedCentralGoogle Scholar
  29. 29.
    Schuck P (2000) Biophys J 78:1606–1619CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of British ColumbiaVancouverCanada

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