Advertisement

C-Reactive Protein (CRP) Latex Agglutination Test

  • Rowa Yousef Alhabbab
Chapter
Part of the Techniques in Life Science and Biomedicine for the Non-Expert book series (TLSBNE)

Abstract

C-reactive proteins (CRP) are one of the non-specific acute phase proteins that are produced from the liver cells as a response to tissue damage, infection, and inflammation. In clinical laboratories, CRP is measured as an indicator of active infection, chronic inflammatory diseases, and in some cases as a risk predictor for cardiovascular diseases. In this chapter, the principle, applications, reagents, steps, and results interpretation for the most commonly used test in serology for detecting CRP are explained.

Keywords

Acute phase proteins CRP hsCRP Latex agglutination 

References

  1. 1.
    Guo L, Liu S, Zhang S, Chen Q, Zhang M, Quan P, et al. C-reactive protein and risk of breast cancer: a systematic review and meta-analysis. Sci Rep. 2015;5:10508.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Mahmoud FA, Rivera NI. The role of C-reactive protein as a prognostic indicator in advanced cancer. Curr Oncol Rep. 2002;4(3):250–5.CrossRefPubMedGoogle Scholar
  3. 3.
    Heikkila K, Harris R, Lowe G, Rumley A, Yarnell J, Gallacher J, et al. Associations of circulating C-reactive protein and interleukin-6 with cancer risk: findings from two prospective cohorts and a meta-analysis. Cancer Causes Control. 2009;20(1):15–26.CrossRefPubMedGoogle Scholar
  4. 4.
    Poole EM, Lee IM, Ridker PM, Buring JE, Hankinson SE, Tworoger SS. A prospective study of circulating C-reactive protein, interleukin-6, and tumor necrosis factor alpha receptor 2 levels and risk of ovarian cancer. Am J Epidemiol. 2013;178(8):1256–64.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Yousuf O, Mohanty BD, Martin SS, Joshi PH, Blaha MJ, Nasir K, et al. High-sensitivity C-reactive protein and cardiovascular disease: a resolute belief or an elusive link? J Am Coll Cardiol. 2013;62(5):397–408.CrossRefPubMedGoogle Scholar
  6. 6.
    Pepys MB, Hirschfield GM. C-reactive protein: a critical update. J Clin Invest. 2003;111(12):1805–12.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Kuller LH, Tracy RP, Shaten J, Meilahn EN. Relation of C-reactive protein and coronary heart disease in the MRFIT nested case-control study. Multiple Risk Factor Intervention Trial. Am J Epidemiol. 1996;144(6):537–47.CrossRefPubMedGoogle Scholar
  8. 8.
    Musunuru K, Kral BG, Blumenthal RS, Fuster V, Campbell CY, Gluckman TJ, et al. The use of high-sensitivity assays for C-reactive protein in clinical practice. Nat Clin Pract Cardiovasc Med. 2008;5(10):621–35.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Ridker PM, Cushman M, Stampfer MJ, Tracy RP, Hennekens CH. Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med. 1997;336(14):973–9.CrossRefPubMedGoogle Scholar
  10. 10.
    Pulse scientific INC. C-Reactive Protein (CRP) Latex Test. Pulsescientific. Available from: file:///Users/drr/Downloads/Pulse_Latex_CRP_Instructions_en.pdf. Accessed 11 September 2017.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Rowa Yousef Alhabbab
    • 1
  1. 1.Division of Applied Medical Sciences and Infectious Disease UnitKing Fahad Centre for Medical Research, King Abdulaziz UniversityJeddahSaudi Arabia

Personalised recommendations