Vaccines in the Immunocompromised Hosts

  • Paratosh Prasad
  • John TreanorEmail author


Vaccination remains the single most effective means available to prevent infectious diseases and mitigate their impact on the health of individuals. However, conditions that result in impairment of adaptive immunity both increase the risk and severity of these infections, as well as decreasing the efficacy of immunizations, posing unique challenges to medical care of these vulnerable patients. In addition, the complex relationships between the immunity of the subject and the mechanisms by which vaccines stimulate the immune system raise safety concerns as well, particularly related to the safety of live vaccines in this population, and the possibility that non-specific stimulation of the immune system could precipitate transplant rejection or increasing autoimmunity.


Vaccines Efficacy Safety Immunocompromised HIV Solid organ transplant Hematologic transplant 


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Division of Infectious DiseasesUniversity of Rochester Medical CenterRochesterUSA

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