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Role of Histamine in Inflammatory Diseases

  • Anette T. Hansen Selnø
  • Vadim V. Sumbayev
  • Ulrike Raap
  • Bernhard F. Gibbs
Chapter

Abstract

Histamine plays a major role in inflammation associated with many different diseases, including allergies, autoimmune diseases and cancer, but it also has important physiological effects. Although mast cells and basophils are the main sources of histamine it can be differentially produced and released by enterochromaffin-like cells, certain nerve cells, and even neutrophils in certain pathological settings. This chapter highlights the recent developments regarding the major contributions of histamine to inflammation by acting not only through H1-receptors (H1R) but also H2R and H4R. These receptors determine both the severity of inflammation and also have immunomodulatory effects in various lymphocytes. Recent evidence also suggests a dual role for histamine in various autoimmune inflammatory disease and certain cancers, where differential receptor expressions for the amine determine the severity of these diseases but also play a role in tumour surveillance.

Keywords

Histamine Mast cells Basophils Allergy Inflammation Cancer 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Anette T. Hansen Selnø
    • 1
  • Vadim V. Sumbayev
    • 1
  • Ulrike Raap
    • 2
  • Bernhard F. Gibbs
    • 2
  1. 1.School of PharmacyUniversity of KentKentUK
  2. 2.Faculty of Medicine and Health Sciences (Dermatology, W16), Department of Dermatology and AllergyUniversity of OldenburgOldenburgGermany

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