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Innate Immunity and Inflammation: The Molecular Mechanisms Governing the Cross-Talk Between Innate Immune and Endothelial Cells

  • Daiane Boff
  • Caio Tavares Fagundes
  • Remo Castro Russo
  • Flavio Almeida Amaral
Chapter

Abstract

The innate immune response comprises the initial events that occur during tissue insult, causing cellular activation and triggering inflammation. Innate immune cells, including resident and early migrated cells from the bloodstream, sense a plethora of molecules called molecular patterns, that are derived from microorganisms or host cells. Once activated, pattern recognition receptor (PRR) signalling is triggered intracellularly and promotes the synthesis and release of vasoactive molecules, which target endothelial cells and cause inflammation. In addition, circulating molecules and pathogens also activate PRRs that are expressed on endothelial cells. These events modify endothelial cell metabolism, changing their conformational state and promoting the expression of pro-inflammatory molecules. Importantly, gain-of-function mutations in PRRs are associated with continuous cellular activation, leading to the development of autoinflammatory diseases. Here, we discuss the relationship among the cellular and humoral arms of the innate immune system in inflammatory processes, with special attention given to endothelial cell activation.

Keywords

Innate immunity Inflammation Pattern recognition receptors Cellular metabolism Autoinflammatory diseases 

Notes

Conflicts of Interest

The authors declare no conflicts of interest.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Daiane Boff
    • 1
  • Caio Tavares Fagundes
    • 2
  • Remo Castro Russo
    • 3
  • Flavio Almeida Amaral
    • 1
  1. 1.Laboratório de Imunofarmacologia, Departamento de Bioquímica e ImunologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Laboratório de Interação Microrganismo-Hospedeiro, Departamento de MicrobiologiaUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  3. 3.Laboratório de Imunologia e Mecânica Pulmonar, Departamento de Fisiologia e BiofísicaUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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