Non-canonical Roles of Nuclear Pore Proteins

  • Douglas R. Mackay
  • Katharine S. UllmanEmail author
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 33)


Thousands of nuclear pore complexes stud the nuclear envelope of a proliferating mammalian cell. At these sites, ∼30 proteins, each present in multiple copies, come together to provide a selective trafficking gateway. In addition to this vital canonical role in nucleocytoplasmic trafficking, a wide variety of other important biological functions are carried out by nuclear pore proteins. In this chapter, we survey the broad range of noncanonical roles that nuclear pore proteins play beyond the nuclear pore complex: during mitosis, in the regulation of gene expression, in response to DNA damage, at primary cilia, and as a signaling or tethering platform for other cellular processes. This chapter provides a snapshot of the scientific literature that emphasizes an ever-growing appreciation of the diverse contributions that nuclear pore proteins make to cell biology. This broader context is particularly important when considering experimental and disease-related phenotypes that arise when the role of a nuclear pore protein is impaired. An appreciation of non-canonical roles also underscores the potential for regulatory cross-talk between the status of nucleocytoplasmic trafficking and other cell functions.


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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Oncological SciencesHuntsman Cancer Institute, University of UtahSalt Lake CityUSA

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