Warm Autoantibodies During Pregnancy
Warm autoantibodies (WAAs) are typically immunoglobulin G (IgG) antibodies directed against red blood cells (RBCs) that react maximally at 37 °C. They are detected in 1:1000 to 1:50,000 of pregnancies. WAAs may rarely cause a warm autoimmune hemolytic anemia (WAIHA), but most WAAs do not result in hemolysis. If WAAs are detected in a pregnant patient, the patient should be evaluated for RBC hemolysis. If there is hemolysis, the patient should be referred to a hematologist for further care. If there is no hemolysis, the patient may be managed similar to a pregnant patient that does not have red cell antibodies.
KeywordsWarm autoantibodies Pregnancy Autoimmune Hemolytic anemia Hemolysis