Abstract
Warm autoantibodies (WAAs) are typically immunoglobulin G (IgG) antibodies directed against red blood cells (RBCs) that react maximally at 37 °C. They are detected in 1:1000 to 1:50,000 of pregnancies. WAAs may rarely cause a warm autoimmune hemolytic anemia (WAIHA), but most WAAs do not result in hemolysis. If WAAs are detected in a pregnant patient, the patient should be evaluated for RBC hemolysis. If there is hemolysis, the patient should be referred to a hematologist for further care. If there is no hemolysis, the patient may be managed similar to a pregnant patient that does not have red cell antibodies.
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References
Sokol RJ, Hewitt S, Stamps BK. Erythrocyte autoantibodies, autoimmune haemolysis and pregnancy. Vox Sang. 1982;43(4):169–76.
Sürücü G, Mayer B, Märzacker A, et al. Harmless pregnancy-induced warm autoantibodies to red blood cells. Transfus Med Hemother. 2015;42:325–7.
Hoppe B, Stibbe W, Bielefeld A, et al. Increased RBC autoantibody production in pregnancy. Transfusion. 2001;41:1559–61.
Packman C. Hemolytic anemia due to warm autoantibodies. Blood Rev. 2008;22:17–31.
Wheeler C, Calhoun L, Blackall D. Warm reactive autoantibodies: clinical and serologic correlations. Am J Clin Pathol. 2004;122:680–5.
Ziman A, Cohn C, Carey P, et al. Warm-reactive (immunoglobulin G) autoantibodies and laboratory testing best practices: review of the literature and survey of current practice. Transfusion. 2017;57:463–77.
Bellia M, Georgopoulos J, Tsevrenis V, et al. The investigation of the significance of a positive direct antiglobulin test in blood donors. Immunohematology. 2002;18:78–81.
Petz L, Garraty G. Unusual aspects of acquired immune hemolytic anemias. In: Petz L, Garraty G, editors. Immune hemolytic anemias. 2nd ed. Philadelphia, PA: Churchill Livingstone; 2004.
Blackall D. How do I approach patients with warm reactive autoantibodies? Transfusion. 2011;51:14–7.
Packman C. The clinical pictures of autoimmune hemolytic anemias. Transfus Med Hemother. 2015;42(5):317–24.
Flores G, Cunningham-Rundles C, Newland AC, et al. Efficacy of intravenous immunoglobulin in the treatment of autoimmune hemolytic anemia: results in 73 patients. Am J Hematol. 1993;44:237–42.
Ong M, Hawthorne L. Autoimmune hemolytic anemia in pregnancy. Lab Med. 2010;41(5):264–6.
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Gavva, C. (2018). Warm Autoantibodies During Pregnancy. In: Nester, T. (eds) Transfusion Management of the Obstetrical Patient. Springer, Cham. https://doi.org/10.1007/978-3-319-77140-3_22
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DOI: https://doi.org/10.1007/978-3-319-77140-3_22
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