Lenalidomide for the Treatment of MDS

  • Aristoteles GiagounidisEmail author
  • Lionel AdèsEmail author
Part of the Hematologic Malignancies book series (HEMATOLOGIC)


Myelodysplastic syndromes (MDS) constitute a heterogeneous group of clonal hematopoietic disorders characterized by bone marrow (BM) failure, dysplasia, and an increased risk of developing acute myeloid leukemia (AML) [1]. The most prevalent cytogenetic abnormality is a partial deletion of the long arm of chromosome 5, del(5q), which is present in about 15% of cases [2]. Anemia is the predominant cytopenia in the large majority of low-risk MDS cases, being the focus of most therapeutic interventions. It often requires repeated RBC transfusions, leading to potential iron overload.



This work was in part supported by the Deutsche José Carreras Leukämie-Stiftung.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Marien Hospital DüsseldorfKlinik für Onkologie, Hämatologie und PalliativmedizinDüsseldorfGermany
  2. 2.Hopital Saint Louis and Paris 7 UniversityParisFrance

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