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Erythropoiesis-Stimulating Agents in Low-Risk MDS

  • S. Park
  • K. Götze
Chapter
Part of the Hematologic Malignancies book series (HEMATOLOGIC)

Abstract

Patients with lower-risk myelodysplastic syndromes (MDS) are affected mainly by chronic anemia and fatigue rather than progression to acute myeloid leukemia. The main aim of treatment is to improve anemia and decrease red blood cell transfusions. Erythropoiesis-stimulating agents (ESAs) are generally first-line therapy, yielding a response in about half of the patients for around 2 years. Predictive factors of response remain non-transfusion dependence and sEPO <200 IU/L. For refractory or relapsing patients after ESA, strategies include lenalidomide alone or with ESA, azacitidine, or luspatercept. For patients with del 5q, lenalidomide is more efficient.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.CHU de Grenoble Alpes, Clinique Universitaire d’Hématologie, Université Grenoble Alpes, Institute for Advanced BiosciencesGrenoble Cedex 09France
  2. 2.Department of Medicine IIIKlinikum rechts der Isar, Technische Universität MünchenMunichGermany

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