Pathogens and Cancer: Clonal Processes and Evolution
There is evidence of interrelations between the immune system and the development of cancer. The intersection between the two: cancer <-> immune response may depend upon the interaction with pathogens. Hosts and pathogens interact so that clones may develop. Cancer and clonal development, like other biological events evolved, seem to share an affinity: cancer and clonality are considered evolutionary processes. From a phylogenetic perspective, information supports an area of affinity. A mechanism has been identified, the existence of suppression via p53, a well-known suppressor. Returning to the relation between the development of clonal responses and an inducer may depend upon the characteristics of the pathogen. Nonpathogenic antigens induce short-lived specific responses generated and mediated by clones that are specific and therefore express specific destruction. Most pathogens (viruses, fungi, bacteria) are harmful, but some do not induce infections. The living world includes a staggering array of life, and each life form may be vulnerable to attack by pathogens that cause disease and, ultimately, death.
KeywordsClonality Pathogen Cancer Immunity p53
I wish to express sincere appreciation to Hillary Brown, whose dedication helped immeasurably to prepare the final version. Nora Wells, Jason Lee, Nicola Overstreet, and Ralph Albert, my students, also worked during the early stages to develop this manuscript.
With kind permission from Springer Science+Business Media: Earthworm Innate Immune System, chapter 14/article title, 24, 2011, 229–45, Engelmann P, Cooper EL, Opper B, Nemeth P Fig. 14.1. Soil Biol.
Reprinted with permission from Macmillan Publishers Ltd. on behalf of Cancer Research UK: Greaves M, Maley CC (2012) Clonal evolution in cancer. Nature 481(7381): 306–13.
We also acknowledge the reproduced/adapted with permission Figs. 2, 3, 5 and 6 from Ohsawa S, Sugimura K, Takino K, Xu T, Miyawaki A, Igaki T (2011) Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell 20(3): 315–28, and Lemmi Carlos AE, Cooper EL (1981) Induction of coelomocyte proliferation by xenografts in the earthworm Lumbricus terrestris. Dev Comp Immunol 5:73–80.
- Assaily W (2005) p53: Guardian of multicellularity? A short essay on multicellular evolution and p53. Hypothesis 1(1):14–15Google Scholar
- Bailey S, Miller BJ, Cooper EL (1971) Transplantation immunity in annelids. II. Adoptive transfer of the xenograft reaction. Immunol 21(1):81–86Google Scholar
- Bryant PJ, Watson KL, Justice RW, Woods DF (1993) Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila. Dev Suppl 119:239–249Google Scholar
- Cooper EL (2010c) Earthworms: harnessing one of nature’s cancer killers. Oncol News Int 19(7):1–3Google Scholar
- Cooper EL (2016) Commentary: blurring borders: innate immunity with adaptive features. Front Immunol 7:358Google Scholar
- Díaz Cosín DJ, Novo M, Fernández R (2011) Reproduction of earthworms: sexual selection and parthenogenesis. In: Karaca A (ed) Biology of earthworms. Springer, Heidelberg, pp 1–19Google Scholar
- Domazet-Lošo T, Klimovich A, Anokhin B, Anton-Erxleben F, Hamm MJ, Lange C, Bosch TC (2014) Naturally occurring tumours in the basal metazoan Hydra. Nat Commun 5(4222):1–8Google Scholar
- Hostetter RK, Cooper EL (1974) Contemporary topics in immunobiology: earthworm coelomocyte immunity. Spring 4:91–107Google Scholar
- James-Clark H (1869) On the spongiae ciliatae as infusoria flagellata; or observations on the structure, animality, and relationship of Leucosolenia botryoides. Ann Mag Nat His 1869(1):133–142. 188–215, 250–264Google Scholar
- Mukherjee S (2010) The emperor of all maladies: a biography of cancer. HarperCollins, New York, pp 1–592Google Scholar
- Pradeu T, Cooper EL (2012) The danger theory: 20 years later. Front Immunol 3(287):1–32Google Scholar
- Saville-Kent W (1881) A manual of the Infusoria: including a description of all known flagellate, ciliate and Tentaculiferous protozoa, British and foreign, and an account of the organization and affinities of the sponges. David Bogue, London, pp 289–720Google Scholar
- Sindermann CJ (1990) Principal diseases of marine fish and shellfish. Academic Press, Inc., San Diego, pp 1–519Google Scholar
- Sparks AK (1985) Synopsis of invertebrate pathology exclusive of insects. Elsevier, Amsterdam, pp 1–423Google Scholar
- Terhivuo J, Saura A (2003) Low clonal diversity and morphometrics in the parthenogenetic earthworm Octolasion cyaneum. Pedobiologia 47:434–439Google Scholar
- Williams CJ (2001) Cancer caused by worms. Los Angeles Times Magazine, pp 40–41Google Scholar