Congenital Factor VII Deficiency

  • Mahmood Shams
  • Akbar Dorgalaleh


Congenital factor VII (FVII) deficiency with a prevalence of 1 per 500,000 is the most common rare bleeding disorder. Although the majority of patients have mild bleeding tendency, a considerable number of them present life-threatening bleedings such as central nervous system (CNS) and gastrointestinal (GI) bleedings. Although the diagnosis of congenital FVII deficiency is straightforward with isolated prolonged prothrombin time (PT) and decreased FVII level, differential diagnosis of acquired FVII deficiency should be considered. Several therapeutic options such as fresh frozen plasma (FFP), plasma-derived FVII (pd-FVII), prothrombin complex concentrate (PCC), activated PCC (aPCC), and, more recently, recombinant activated FVII (rFVIIa) are available for treatment of patients with FVII deficiency. New therapeutic options significantly improved the quality of life in patients with congenital FVII deficiency.


Factor VII deficiency Rare bleeding disorder Clinical manifestations Diagnosis Treatment 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Mahmood Shams
    • 1
    • 2
  • Akbar Dorgalaleh
    • 2
  1. 1.Department of Laboratory Sciences, Paramedical FacultyBabol University of Medical SciencesBabolIran
  2. 2.Department of Hematology and Blood transfusion, School of Allied MedicineIran University of Medical SciencesTehranIran

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