Kallman’s Syndrome and Hypopituitarism

  • Sherman Silber


Idiopathic congenital hypogonadotropic hypogonadism (CHH) is a rare reproductive disorder that is primarily caused by a gonadotropin-releasing hormone (GnRH) deficiency but with significant genetic heterogeneity. Clinically, this disorder is characterized by abnormally low plasma levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) in conjunction with very low concentrations of circulating azoospermia and testosterone, and of course azoospermia. In approximately 50% of cases, CHH patients also suffer from a reduced or deficient sense of smell (hyposmia or anosmia, respectively), which is then termed as Kallmann syndrome (KS) [1–3].


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Sherman Silber
    • 1
    • 2
  1. 1.Infertility Center of St. LouisSt. Luke’s HospitalSt. LouisUSA
  2. 2.University of MichiganAnn ArborUSA

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