Cancer of Other Origin

  • Ben DavidsonEmail author
  • Claire Michael
  • Pınar Fırat


The peritoneal, pleural, and pericardial cavities may be the site of metastasis from practically any malignant tumor, including carcinomas, sarcomas, melanoma, hematological tumors, and pediatric cancers other than the aforementioned entities. The differential diagnosis is critically dependent on the age and gender of the patient, which are in turn likely to impact the choice of immunohistochemistry panels and molecular analyses performed. In adults, carcinomas predominate, and those not originating from the lung, ovary, or breast (discussed in other chapters) are discussed in this chapter, with the main focus on gastrointestinal primaries. Additionally discussed are carcinomas of other origin, including non-ovarian female genital tract cancers and carcinomas of the urothelial tract and the head and neck region. Non-epithelial cancers, including melanoma, sarcomas, and childhood cancers, are additionally discussed. The combination of morphology, immunohistochemistry, and, when mandated, molecular analysis allows for a conclusive diagnosis in the majority of cases.


Gastrointestinal carcinoma Germ cell tumor Sarcoma Childhood cancer Immunohistochemistry 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyThe Norwegian Radium Hospital, Oslo University HospitalOsloNorway
  2. 2.Faculty of MedicineInstitute of Clinical Medicine, University of OsloOsloNorway
  3. 3.UH Cleveland Medical CenterCase Western Reserve UniversityClevelandUSA
  4. 4.Department of PathologySchool of Medicine, Koc UniversityIstanbulTurkey
  5. 5.[Previously] Department of PathologyIstanbul Faculty of Medicine, Istanbul UniversityIstanbulTurkey

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