Errors and Error Management in Biomedical Research

  • Ulrich Dirnagl
  • René Bernard


The authors put a much-needed focus on the validity of biomedical research results that has come under scrutiny. However, as they make clear, due to the complexity of the experiments involved, errors quite naturally occur frequently. A way of managing these errors is the “Laboratory Critical Incident and Error Reporting System” (LabCIRS), a software tool to record all incidents anonymously and to analyze, discuss, and communicate them. It has been adapted from the CIRS, used in the clinical world to improve patient safety in complex, fast-paced, and often understaffed settings.



The authors thank Sebastian Major, Ingo Przesdzing, and Claudia Kurreck for developing, implementing, and testing LabCIRS.

Funding Statement

Ulrich Dirnagl acknowledges the financial support of the German Federal Ministry of Education and Research (BMBF 01 EO 08 01) and the Herman and Lilly Schilling Foundations. The funders had no role in the decision to publish or the preparation of the manuscript.

Competing Interests

None of the authors have any competing interests to declare.


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Copyright information

© The Author(s) 2018

Authors and Affiliations

  • Ulrich Dirnagl
    • 1
  • René Bernard
    • 1
  1. 1.BerlinGermany

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