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Oral Cavity: Malignancies and Precursors

  • Margaret S. Brandwein-Weber
Chapter

Abstract

This chapter discusses the range of oral cavity precursor lesions, the many histologic variants of oral squamous carcinoma, the Risk Model, resection margin assessment, and summarizes the new staging criteria (8th AJCC). Kaposi’s sarcoma is also discussed here, as the oral cavity is the most common extra-cutaneous site for this tumor.

Keywords

Dysplasia Pattern of invasion WPOI-5 Squamous carcinoma Variants Precursor lesions 

References

  1. 1.
    Reibel J, Tilakaratnew WM, Gale N, Westra WH, Hille J, Williams MD, Hunt JL, Vigneswaran N, Lingen M, Fatani HA, Muller S, Odell EW, Sloan P, Zain RB. Oral potentially malignant disorders and oral epithelial dysplasia. In: El-Naggar AK, JKC C, Grandis JR, Takata T, Slootweg PJ, editors. WHO classification of head and neck tumors. 4th ed. Lyon: IARC. 2015; p. 112–5.Google Scholar
  2. 2.
    Gopinath D, Thannikunnath BV, Neermunda SF. Prevalence of carcinomatous foci in oral leukoplakia: a clinicopathologic study of 546 Indian samples. J Clin Diagn Res. 2016;10(8):ZC78–83.PubMedPubMedCentralGoogle Scholar
  3. 3.
    Bradley G, Odell EW, Raphael S, Ho J, Le LW, Benchimol S, Kamel-Reid S. Abnormal DNA content in oral epithelial dysplasia is associated with increased risk of progression to carcinoma. Br J Cancer. 2010;103:1432–42.PubMedPubMedCentralCrossRefGoogle Scholar
  4. 4.
    Liu W, Wang YF, Zhou HW, Shi P, Zhou ZT, Tang GY. Malignant transformation of oral leukoplakia: a retrospective cohort study of 218 Chinese patients. BMC Cancer. 2010;10:685. Published online 2010 Dec 16.  https://doi.org/10.1186/1471-2407-10-685.CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Liu W, Shi LJ, Wu L, Feng JQ, Yang X, Li J, Zhou ZT, Zhang CP. Oral cancer development in patients with leukoplakia – clinicopathological factors affecting outcome. PLoS One. 2012;7(4):e34773.  https://doi.org/10.1371/journal.pone.0034773.PubMedPubMedCentralCrossRefGoogle Scholar
  6. 6.
    Dost F, Lê Cao K, Ford PJ, Ades C, Farah CS. Malignant transformation of oral epithelial dysplasia: a real-world evaluation of histopathologic grading. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;117:343–52.PubMedCrossRefGoogle Scholar
  7. 7.
    Mehanna HM, Rattay T, Smith J, McConkey CC. Treatment and follow-up of oral dysplasia – a systematic review and meta-analysis. Head Neck. 2009;31:1600–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies. J Oral Pathol Med. 2016;45:155–66.PubMedCrossRefGoogle Scholar
  9. 9.
    Wang YY, Tail YH, Wang WC, Chen CY, Kao YH, Chen YK, Chen CH. Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders. BMC Oral Health. 2014.  https://doi.org/10.1186/1472-6831-14-99.
  10. 10.
    Abadie WM, Partington EJ, Fowler CB, Schmalbach CE. Optimal management of proliferative verrucous leukoplakia: a systematic review of the literature. Otolaryngol Head Neck Surg. 2015;153:504–11.PubMedCrossRefPubMedCentralGoogle Scholar
  11. 11.
    Akrish S, Ben-Izhak O, Sabo E, Rachmiel A. Oral squamous cell carcinoma associated with proliferative verrucous leukoplakia compared with conventional squamous cell carcinoma–a clinical, histologic and immunohistochemical study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;119:318–25.PubMedCrossRefPubMedCentralGoogle Scholar
  12. 12.
    Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia (PVL): a review of an elusive pathologic entity! Adv Anat Pathol. 2013;20:416–23.PubMedCrossRefPubMedCentralGoogle Scholar
  13. 13.
    Gillenwater AM, Vigneswaran N, Fatani H, Saintigny P, El-Naggar AK. Proliferative verrucous leukoplakia: recognition and differentiation from conventional leukoplakia and mimics. Head Neck. 2014;36:1662–8.PubMedCrossRefPubMedCentralGoogle Scholar
  14. 14.
    Arakeri G, Patil SG, Aljabab AS, Lin KC, Merkx MA, Gao S, Brennan PA. Oral submucous fibrosis: an update on pathophysiology of malignant transformation. J Oral Pathol Med. 2017.  https://doi.org/10.1111/jop.12582.
  15. 15.
    Arakeri G, Boraks G, Patil SG, Aljabab AS, Merkx MA, Carrozzo M, Brennan PA. Current protocols in the management of oral submucous fibrosis: an update. J Oral Pathol Med. 2017.  https://doi.org/10.1111/jop.12583.
  16. 16.
    Niaz K, Maqbool F, Khan F, Bahadar H, Ismail Hassan F, Abdollahi M. Smokeless tobacco (paan and gutkha) consumption and its prevalence contributing toward oral cancer. Epidemiol Health. 2017.  https://doi.org/10.4178/epih.e2017009.
  17. 17.
    Yang PY, Chen YT, Wang YH, Su NY, Yu HC, Chang YC. Malignant transformation of oral submucous fibrosis in Taiwan: a nationwide population-based retrospective cohort study. J Oral Pathol Med. 2017.  https://doi.org/10.1111/jop.12570.
  18. 18.
    Shirsat PM, Desai RS, Bansal S, Prasad P. Oral epithelial dysplasia in oral submucous fibrosis: a challenge. Oral Oncol. 2016;54:e19.  https://doi.org/10.1016/j.oraloncology.2015.11.005. Epub 2015 Nov 19CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Pandya S, Chaudhary AK, Singh M, Singh M, Ravi Mehrotra R. Correlation of histopathological diagnosis with habits and clinical findings in oral submucous fibrosis. Head Neck Oncol. Published online. 2009.  https://doi.org/10.1186/1758-3284-1-10.
  20. 20.
    Haniffa AM, Saitoh M, Abiko Y, Takeshima M, Nishimura M, Yamazaki M, Nagayasu H, Sugiura C, Muthumala M, Kaku T, Chiba I, Shibata T. Expression pattern of p63 in oral epithelial lesions and submucous fibrosis associated with betel-quid chewing in Sri Lanka. Med Mol Morphol. 2007;40(4):203–7.PubMedCrossRefPubMedCentralGoogle Scholar
  21. 21.
    Gadbail AR, Chaudhary M, Gawande M, Hande A, Sarode S, Tekade SA, Korde S, Zade P, Bhowate R, Borle R, Patil S. Oral squamous cell carcinoma in the background of oral submucous fibrosis is a distinct clinicopathological entity with better prognosis. J Oral Pathol Med. 2017.  https://doi.org/10.1111/jop.12553.
  22. 22.
    Sujatha D, Hebbar PB, Pai A. Prevalence and correlation of oral lesions among tobacco smokers, tobacco chewers, areca nut and alcohol users. Asian Pac J Cancer Prev. 2012;13:1633–7.PubMedCrossRefPubMedCentralGoogle Scholar
  23. 23.
    Greer RO Jr. Oral manifestations of smokeless tobacco use. Otolaryngol Clin N Am. 2011;44:31–56.CrossRefGoogle Scholar
  24. 24.
    Mehta FS, Jalnawalla PN, Daftary DK, Gupta PC, Pindborg JJ. Reverse smoking in Andhra Pradesh, India: variability of clinical and histologic appearances of palatal changes. Int J Oral Surg. 1977;6:75–83.PubMedCrossRefPubMedCentralGoogle Scholar
  25. 25.
    Mehta FS, Sahiar BE, Daftary DK, Gupta PC, Pindborg JJ. A correlative histocytological study of carcinoma and epithelial atypia of the palate among Indian reverse smokers. Br J Cancer. 1972;26:230–3.PubMedPubMedCentralCrossRefGoogle Scholar
  26. 26.
    Pindborg JJ, Mehta FS, Gupta PC, Daftary DK, Smith CJ. Reverse smoking in Andhra Pradesh, India: a study of palatal lesions among 10,169 villagers. Br J Cancer. 1971;25:10–20.PubMedPubMedCentralCrossRefGoogle Scholar
  27. 27.
    Pednekar MS, Gupta PC, Yeole BB, Hébert JR. Association of tobacco habits, including bidi smoking, with overall and site-specific cancer incidence: results from the Mumbai cohort study. Cancer Causes Control. 2011;22:859–68.PubMedPubMedCentralCrossRefGoogle Scholar
  28. 28.
    Hongal BP, Kulkarni VV, Deshmukh RS, Joshi PS, Karande PP, Shroff AS. Prevalence of fungal hyphae in potentially malignant lesions and conditions—does its occurrence play a role in epithelial dysplasia? J Oral Maxillofac Pathol. 2015;19:10–7.PubMedPubMedCentralCrossRefGoogle Scholar
  29. 29.
    McCullough M, Jaber M, Barrett AW, Bain L, Speight PM, Porter SR. Oral yeast carriage correlates with presence of oral epithelial dysplasia. Oral Oncol. 2002;38:391–3.PubMedCrossRefPubMedCentralGoogle Scholar
  30. 30.
    de Sousa LVNF, Santos VL, Monteiro AS, Dias-Souza MV, Marques SG, Faria ES, Assunção EAO, Santos SG, Zonis JM, Alvarenga DG, Holanda RA, de Sousa JG, Santos KV, Stoianoff MAR. Isolation and identification of Candida species in patients with orogastric cancer: susceptibility to antifungal drugs, attributes of virulence in vitro and immune response phenotype. BMC Infect Dis. 2016;16:86. Published online 2016 Feb 23.  https://doi.org/10.1186/s12879-016-1431.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Bakri MM, Hussaini HM, Holmes AR, Cannon RD, Rich AM. Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. J Oral Microbiol. 2010.  https://doi.org/10.3402/jom.v2i0.5780.
  32. 32.
    Czerninski R, Zeituni S, Maly A, Basile J. Clinical characteristics of lichen and dysplasia vs lichen planus cases and dysplasia cases. Oral Dis. 2015;21:478–82.PubMedCrossRefGoogle Scholar
  33. 33.
    Patil S, Rao RS, Sanketh DS, Warnakulasuriya S. Lichenoid dysplasia revisited – evidence from a review of Indian archives. J Oral Pathol Med. 2015;44:507–14.PubMedCrossRefPubMedCentralGoogle Scholar
  34. 34.
    Fitzpatrick SG, Hirsch SA, Gordon SC. The malignant transformation of oral lichen planus and oral lichenoid lesions: a systematic review. J Am Dent Assoc. 2014;145:45–56.PubMedCrossRefPubMedCentralGoogle Scholar
  35. 35.
    Liu W, Shen ZY, Wang LJ, Hu YH, Shen XM, Zhou ZT, Li J. Malignant potential of oral and labial chronic discoid lupus erythematosus: a clinicopathological study of 87 cases. Histopathology. 2011;59:292–8.PubMedCrossRefPubMedCentralGoogle Scholar
  36. 36.
    Fernandes MS, Girisha BS, Viswanathan N, Sripathi H, Noronha TM. Discoid lupus erythematosus with squamous cell carcinoma: a case report and review of the literature in Indian patients. Lupus. 2015;24:1562–6.PubMedCrossRefGoogle Scholar
  37. 37.
    Jadotte YT, Schwartz RA. Solar cheilosis: an ominous precursor: part I. Diagnostic insights. J Am Acad Dermatol. 2012;66:173–84.PubMedCrossRefPubMedCentralGoogle Scholar
  38. 38.
    Cavalcante AS, Anbinder AL, Carvalho YR. Actinic cheilitis: clinical and histological features. J Oral Maxillofac Surg. 2008;66:498–503.PubMedCrossRefPubMedCentralGoogle Scholar
  39. 39.
    Speight PM, Abram TJ, Floriano PN, James R, Vick J, Thornhill MH, McDevitt JT. Inter-observer agreement in dysplasia grading: towards an enhanced gold standard for clinical pathology trials. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(4):474–482.e2.PubMedCentralCrossRefGoogle Scholar
  40. 40.
    Bouquot JE, Speight PM, Farthing PM. Epithelial dysplasia of the oral mucosa—Diagnostic problems and prognostic features. Curr Diagn Pathol. 2006;12:11–21.CrossRefGoogle Scholar
  41. 41.
  42. 42.
    Simard EP, Torre LA, Jemal A. International trends in head and neck cancer incidence rates: differences by country, sex and anatomic site. Oral Oncol. 2014;50:387–403.PubMedCrossRefPubMedCentralGoogle Scholar
  43. 43.
    Tataru D, Mak V, Simo R, Davies EA, Gallagher JE. Trends in the epidemiology of head and neck cancer in London. Clin Otolaryngol. 2017;42:104–14.PubMedCrossRefPubMedCentralGoogle Scholar
  44. 44.
    Shridhar K, Rajaraman P, Koyande S, Parikh PM, Chaturvedi P, Dhillon PK, Dikshit RP. Trends in mouth cancer incidence in Mumbai, India (1995–2009): an age-period-cohort analysis. Cancer Epidemiol. 2016;42:66–71.PubMedPubMedCentralCrossRefGoogle Scholar
  45. 45.
    Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, Soerjomataram I. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 2017;67:51–64.PubMedCrossRefGoogle Scholar
  46. 46.
    Siddiqi K, Shah S, Abbas SM, Vidyasagaran A, Jawad M, Dogar O, Sheikh A. Global burden of disease due to smokeless tobacco consumption in adults: analysis of data from 113 countries. BMC Med. 2015;13:194–216.PubMedPubMedCentralCrossRefGoogle Scholar
  47. 47.
    Mishra A, Meherotra R. Head and neck cancer: global burden and regional trends in India. Asian Pac J Cancer Prev. 2014;15:537–50.PubMedCrossRefGoogle Scholar
  48. 48.
    Gupta B, Johnson NW, Kumar N. Global epidemiology of head and neck cancers: a continuing challenge. Oncology. 2016;91:13–23.PubMedCrossRefGoogle Scholar
  49. 49.
    Smith EM, Rubenstein LM, Haugen TH, Pawlita M, Turek LP. Complex etiology underlies risk and survival in head and neck cancer human papillomavirus, tobacco, and alcohol: a case for multifactor disease. J Oncol. 2012;2012:571862. Published online 2012 Jan 23.  https://doi.org/10.1155/2012/571862.CrossRefPubMedPubMedCentralGoogle Scholar
  50. 50.
    Zhang Y, Wang R, Miao L, Zhu L, Jiang H, Yuan H. Different levels in alcohol and tobacco consumption in head and neck cancer patients from 1957 to 2013. PLoS One. 2015;10(4):e0124045.PubMedPubMedCentralCrossRefGoogle Scholar
  51. 51.
    Radoï L, Menvielle G, Cyr D, Lapôtre-Ledoux B, Stücker I, Luce D. ICARE study group Population attributable risks of oral cavity cancer to behavioral and medical risk factors in France: results of a large population-based case–control study, the ICARE study. BMC Cancer. 2015;15:827. Published online 2015 Oct 31.  https://doi.org/10.1186/s12885-015-1841-5.CrossRefPubMedPubMedCentralGoogle Scholar
  52. 52.
    Isayeva T, Xu J, Ragin C, Dai Q, Cooper T, Carroll W, Dayan D, Vered M, Wenig B, Rosenthal E, Grizzle W, Anderson J, Willey CD, Yang ES, Brandwein-Gensler M. The protective effect of p16(INK4a) in oral cavity carcinomas: p16(Ink4A) dampens tumor invasion-integrated analysis of expression and kinomics pathways. Mod Pathol. 2015;28:631–53.PubMedCrossRefGoogle Scholar
  53. 53.
    Alamgir MM, Jamal Q, Mirza T. Conventional clinical and prognostic variables in 150 oral squamous cell carcinoma cases from the indigenous population of Karachi. Pak J Med Sci. 2016;32(3):672–6.  https://doi.org/10.12669/pjms.323.9905.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Gupta B, Johnson NW. Systematic review and meta-analysis of association of smokeless tobacco and of betel quid without tobacco with incidence of oral cancer in South Asia and the Pacific. PLoS One. 2014;9(11):e113385. Published online 2014 Nov 20.  https://doi.org/10.1371/journal.pone.0113385.CrossRefPubMedPubMedCentralGoogle Scholar
  55. 55.
    Maxwell JH, Thompson LD, Brandwein-Gensler MS, Weiss BG, Canis M, Purgina B, Prabhu AV, Lai C, Shuai Y, Carroll WR, Morlandt A, Duvvuri U, Kim S, Johnson JT, Ferris RL, Seethala R, Chiosea SI. Early oral tongue squamous cell carcinoma:sampling of margins from tumor bed and worse local control. JAMA Otolaryngol Head Neck Surg. 2015;141:1104–10.PubMedPubMedCentralCrossRefGoogle Scholar
  56. 56.
    Buchakjian MR, Tasche KK, Robinson RA, Pagedar NA, Sperry SM. Association of main specimen and tumor bed margin status with local recurrence and survival in oral cancer surgery. JAMA Otolaryngol Head Neck Surg. 2016;142:1191–8.PubMedCrossRefGoogle Scholar
  57. 57.
    Liao CT, Chang JT, Wang HM, Ng SH, Hsueh C, Lee LY, Lin CH, Chen IH, Huang SF, Cheng AJ, Yen TC. Analysis of risk factors of predictive local tumor control in oral cavity cancer. Ann Surg Oncol. 2008;15(3):915–22.PubMedCrossRefPubMedCentralGoogle Scholar
  58. 58.
    Tasche KK, Buchakjian MR, Pagedar NA, Sperry SM. Definition of “close margin” in oral cancer surgery and association of margin distance with local recurrence rate. JAMA Otolaryngol Head Neck Surg. 2017.  https://doi.org/10.1001/jamaoto.2017.0548.
  59. 59.
    Zanoni DK, Migliacci JC, Xu B, Katabi N, Montero PH, Ganly I, Shah JP, Wong RJ, Ghossein RA, Patel SG. A proposal to redefine close surgical margins in squamous cell carcinoma of the oral tongue. JAMA Otolaryngol Head Neck Surg. 2017.  https://doi.org/10.1001/jamaoto.2016.4238.
  60. 60.
    Ebrahimi A, Gil Z, Amit M, Yen TC, Liao CT, Chaturvedi P, Agarwal JP, Kowalski LP, Kreppel M, Cernea CR, Brandao J, Bachar G, Bolzoni Villaret A, Fliss D, Fridman E, Robbins KT, Shah JP, Patel SG, Clark JR. Primary tumor staging for oral cancer and a proposed modification incorporating depth of invasion: an international multicenter retrospective study. JAMA Otolaryngol Head Neck Surg. 2014;140:1138–48.PubMedCrossRefPubMedCentralGoogle Scholar
  61. 61.
    Prabhu RS, Hanasoge S, Magliocca KR, Moeller BJ, Milas ZL, Hall WA, El-Deiry M, Wadsworth JT, Higgins KA, Beitler JJ. Extent of pathologic extracapsular extension and outcomes in patients with nonoropharyngeal head and neck cancer treated with initial surgical resection. Cancer. 2014;120:1499–506.PubMedCrossRefPubMedCentralGoogle Scholar
  62. 62.
    Wreesmann VB, Katabi N, Palmer FL, Montero PH, Migliacci JC, Gönen M, Carlson D, Ganly I, Shah JP, Ghossein R, Patel SG. Influence of extracapsular nodal spread extent on prognosis of oral squamous cell carcinoma. Head Neck. 2016;38(Suppl 1):E1192–9.  https://doi.org/10.1002/hed.24190.CrossRefPubMedPubMedCentralGoogle Scholar
  63. 63.
    Subramaniam N, Balasubramanian D, Murthy S, Limbachiya S, Thankappan K, Iyer S. Adverse pathologic features in early oral squamous cell carcinoma and the role of postoperative radiotherapy-a review. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;pii: S2212–4403(17):30104–9.  https://doi.org/10.1016/j.oooo.2017.03.002.CrossRefGoogle Scholar
  64. 64.
    Chatzistefanou I, Lubek J, Markou K, Ord RA. The role of perineural invasion in treatment decisions for oral cancer patients: A review of the literature. J Craniomaxillofac Surg. 2017;pii: S1010–5182(17):30082–3.  https://doi.org/10.1016/j.jcms.2017.02.022.CrossRefGoogle Scholar
  65. 65.
    Barry CP, Wong D, Clark JR, Shaw RJ, Gupta R, Magennis P, Triantafyllou A, Gao K, Brown JS. Postoperative radiotherapy for patients with oral squamous cell carcinoma with intermediate risk of recurrence: A case match study. Head Neck. 2017.  https://doi.org/10.1002/hed.24780. [Epub ahead of print] PubMed.
  66. 66.
    Brandwein-Gensler M, Teixeira M, Lewis C, et al. Oral squamous cell carcinoma: histological risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. Am J Surg Pathol. 2005;29:167–78.PubMedCrossRefPubMedCentralGoogle Scholar
  67. 67.
    Brandwein-Gensler M, Smith RV, Wang B, Penner C, Thielken A, Broughel D, Schiff B, Owen RP, Smith J, Sarta C, Hebert T, Nason R, Ramer M, Delacure M, Hirsch D, Myssiorek D, Heller K, Prystowsky M, Schlecht N, Negassa A. Validation of the histological risk model in a new patient cohort with primary head and neck squamous cell carcinoma. Am J Surg Pathol. 2010;34:676–88.PubMedPubMedCentralGoogle Scholar
  68. 68.
    Li Y, Bai S, Carroll W, Dayan D, Dort JC, Heller K, Jour G, Lau H, Penner C, Prystowsky M, Rosenthal E, Schlecht NF, Smith RV, Urken M, Vered M, Wang B, Wenig B, Negassa A, Brandwein-Gensler M. Validation of the risk model: high-risk classification and tumor pattern of invasion predict outcome for patients with low-stage oral squamous cell carcinoma. Head Neck Pathol. 2013;7:211–23.PubMedCrossRefPubMedCentralGoogle Scholar
  69. 69.
    Jakobsson PÅ, Eneroth CM, Killander D, et al. Histologic classification and grading of malignancy in carcinoma of the larynx. Acta Radiol Ther Phys Biol. 1973;12:1–8.PubMedCrossRefGoogle Scholar
  70. 70.
    Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis. 1998;4:70–7.PubMedCrossRefGoogle Scholar
  71. 71.
    Bryne M, Koppang HS, Lilleng R, et al. New malignancy grading is a better prognostic indicator than Broders’ grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989;18:432–7.PubMedCrossRefGoogle Scholar
  72. 72.
    Miller ME, Palla B, Chen Q, Elashoff DA, Abemayor E, St John MA, Lai CK. A novel classification system for perineural invasion in noncutaneous head and neck squamous cell carcinoma: histologic subcategories and patient outcomes. Am J Otolaryngol. 2012;33:212–5.PubMedCrossRefGoogle Scholar
  73. 73.
    Arora A, Husain N, Bansal A, Neyaz A, Jaiswal R, Jain K, Chaturvedi A, Anand N, Malhotra K, Shukla S. Development of a new outcome prediction model in early-stage squamous cell carcinoma of the oral cavity based on histopathologic parameters with multivariate analysis: the Aditi-Nuzhat lymph-node prediction score (ANLPS) system. Am J Surg Pathol. 2017.  https://doi.org/10.1097/PAS.0000000000000843.
  74. 74.
    Hori Y, Kubota A, Yokose T, Furukawa M, Matsushita T, Takita M, Mitsunaga S, Mizoguchi N, Nonaka T, Nakayama Y, Oridate N. Predictive significance of tumor depth and budding for late lymph node metastases in patients with clinical N0 early oral tongue carcinoma. Head Neck Pathol. 2017.  https://doi.org/10.1007/s12105-017-0814-1.
  75. 75.
    Attramadal CG, Kumar S, Boysen ME, Dhakal HP, Nesland JM, Bryne M. Tumor budding, EMT and cancer stem cells in T1-2/N0 oral squamous cell carcinomas. Anticancer Res. 2015;35:6111–20.PubMedPubMedCentralGoogle Scholar
  76. 76.
    Numico G, Silvestris N, Grazioso RE. Advances in EGFR-directed therapy in head and neck cancer. Front Biosci (Schol Ed). 2011;3:454–66.CrossRefGoogle Scholar
  77. 77.
    Koch DT, Pickhard A, Gebel L, Buchberger AMS, Bas M, Mogler C, Reiter R, Piontek G, Wirth M. Epidermal growth factor receptor variant III in head and neck squamous cell carcinoma is not relevant for targeted therapy and irradiation. Oncotarget. 2017;8(20):32668–82.  https://doi.org/10.18632/oncotarget.15949.CrossRefPubMedCentralGoogle Scholar
  78. 78.
    Alterio D, Marvaso G, Maffini F, Gandini S, Chiocca S, Ferrari A, Preda L, Rocca MC, Lepanto D, Fodor C, Volpe S, Dicuonzo S, Laudati A, Giugliano G, Ansarin M, Jereczek-Fossa BA. Role of EGFR as prognostic factor in head and neck cancer patients treated with surgery and postoperative radiotherapy: proposal of a new approach behind the EGFR overexpression. Med Oncol. 2017;34(6):107.  https://doi.org/10.1007/s12032-017-0965-7.CrossRefPubMedPubMedCentralGoogle Scholar
  79. 79.
    Boeckx C, Weyn C, Vanden Bempt I, Deschoolmeester V, Wouters A, Specenier P, Van Laer C, Van den Weyngaert D, Kockx M, Vermorken JB, Peeters M, Pauwels P, Lardon F, Baay M. Mutation analysis of genes in the EGFR pathway in head and neck cancer patients: implications for anti-EGFR treatment response. BMC Res Notes. 2014;7:337.  https://doi.org/10.1186/1756-0500-7-337.CrossRefPubMedPubMedCentralGoogle Scholar
  80. 80.
    de Boer E, Warram JM, Tucker MD, Hartman YE, Moore LS, de Jong JS, Chung TK, Korb ML, Zinn KR, van Dam GM, Rosenthal EL, Brandwein-Gensler MS. In Vivo fluorescence immunohistochemistry: localization of fluorescently labeled cetuximab in squamous cell carcinomas. Sci Rep. 2015;5:101692015.Google Scholar
  81. 81.
    Even AJ, Hamming-Vrieze O, van Elmpt W, Winnepenninckx VJ, Heukelom J, Tesselaar ME, Vogel WV, Hoeben A, Zegers CM, Vugts DJ, van Dongen GA, Bartelink H, Mottaghy FM, Hoebers F, Lambin P. Quantitative assessment of Zirconium-89 labeled cetuximab using PET/CT imaging in patients with advanced head and neck cancer: a theragnostic approach. Oncotarget. 2017;8(3):3870–80.PubMedCrossRefPubMedCentralGoogle Scholar
  82. 82.
    Bauman JE, Duvvuri U, Gooding WE, Rath TJ, Gross ND, Song J, Jimeno A, Yarbrough WG, Johnson FM, Wang L, Chiosea S, Sen M, Kass J, Johnson JT, Ferris RL, Kim S, Hirsch FR, Ellison K, Flaherty JT, Mills GB, Grandis JR. Randomized,placebo-controlled window trial of EGFR, Src, or combined blockade in head and neck cancer. JCI Insight. 2017;2(6):e90449.  https://doi.org/10.1172/jci.insight.90449.CrossRefPubMedPubMedCentralGoogle Scholar
  83. 83.
    Mann JE, Hoesli R, Michmerhuizen NL, Devenport SN, Ludwig ML, Vandenberg TR, Matovina C, Jawad N, Mierzwa M, Shuman AG, Spector ME, Brenner JC. Surveilling the potential for precision medicine-driven PD-1/PD-L1-targeted therapy in HNSCC. J Cancer. 2017;8:332–44.PubMedPubMedCentralCrossRefGoogle Scholar
  84. 84.
    Kogashiwa Y, Yasuda M, Sakurai H, Nakahira M, Sano Y, Gonda K, Ikeda T, Inoue H, Kuba K, Oba S, Ishikawa J, Enoki Y, Matsumura S, Minami K, Ebihara Y, Sugasawa M. PD-L1 expression confers better prognosis in locally advanced oral squamous cell carcinoma. Anticancer Res. 2017;37:1417–24.PubMedCrossRefGoogle Scholar
  85. 85.
    Sajin M, Hodorogea Prisăcaru A, Luchian MC, Pătraşcu OM, Dumitru A, Costache D, Dumitrescu D, Vrînceanu D, Voinea LM, Simionescu O, Costache M. Acantholytic squamous cell carcinoma: pathological study of nine cases with review of literature. Romanian J Morphol Embryol. 2014;55:279–83.Google Scholar
  86. 86.
    Mardi K, Singh N. Acantholytic squamous cell carcinoma of the oral cavity: a rare entity. J Oral Maxillofac Pathol. 2014;18:S128–30.PubMedPubMedCentralCrossRefGoogle Scholar
  87. 87.
    Gu X, Jiang R, Fowler MR. Acantholytic squamous cell carcinoma in upper aerodigestive tract: histopathology, immunohistochemical profile and epithelial mesenchymal transition phenotype change. Head Neck Pathol. 2012;6:438–44.PubMedPubMedCentralCrossRefGoogle Scholar
  88. 88.
    Lee RJ, Lin T, Lee SA, Lee KK, Christensen RE. Importance of tumor extent in adenosquamous carcinoma of the head and neck: a retrospective cohort study. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;pii: S2212–4403(17):30106–2.  https://doi.org/10.1016/j.oooo.2017.03.004.CrossRefGoogle Scholar
  89. 89.
    Sravya T, Rao GV, Kumar MP, Sudheerkanth K. Oral adenosquamous carcinoma: report of a rare entity with a special insight on its histochemistry. J Oral Maxillofac Pathol. 2016;20:548.PubMedPubMedCentralCrossRefGoogle Scholar
  90. 90.
    Satomi T, Kohno M, Hasagawa O, Enomoto A, Abukawa H, Chikazu D, Yoshida M, Matsubayashi J, Nagao T. Adenosquamous carcinoma of the tongue: clinicopathologic study and review of the literature. Odontology. 2017;105:127–35.PubMedCrossRefPubMedCentralGoogle Scholar
  91. 91.
    Kass JI, Lee SC, Abberbock S, Seethala RR, Duvvuri U. Adenosquamous carcinoma of the head and neck: molecular analysis using CRTC-MAML FISH and survival comparison with paired conventional squamous cell carcinoma. Laryngoscope. 2015;125:E371–6.PubMedCrossRefPubMedCentralGoogle Scholar
  92. 92.
    Masand RP, El-Mofty SK, Ma XJ, Luo Y, Flanagan JJ, Lewis JS. Adenosquamous carcinoma of the head and neck: relationship to human papillomavirus and review of the literature. Head Neck Pathol. 2011;5:108–16.PubMedPubMedCentralCrossRefGoogle Scholar
  93. 93.
    Heera R, Ayswarya T, Padmakumar SK, Ismayil P. Basaloid squamous cell carcinoma of oral cavity: report of two cases. J Oral Maxillofac Pathol. 2016;20:545.PubMedPubMedCentralGoogle Scholar
  94. 94.
    Patel PN, Mutalik VS, Rehani S, Radhakrishnan R. Basaloid squamous cell carcinoma of oral cavity with incongruent clinical course. BMJ Case Rep. 2013;2013. pii:bcr2013200441.  https://doi.org/10.1136/bcr-2013-200441.CrossRefGoogle Scholar
  95. 95.
    Fritsch VA, Gerry DR, Lentsch EJ. Basaloid squamous cell carcinoma of the oral cavity: an analysis of 92 cases. Laryngoscope. 2014;124:1573–8.PubMedCrossRefPubMedCentralGoogle Scholar
  96. 96.
    Khoury ZH, Bugshan A, Lubek JE, Papadimitriou JC, Basile JR, Younis RH. Glycogen-rich clear cell squamous cell carcinoma originating in the oral cavity. Head Neck Pathol. 2017.  https://doi.org/10.1007/s12105-017-0812-3.
  97. 97.
    Kaliamoorthy S, Sethuraman V, Ramalingam SM, Arunkumar S. A rare case of clear cell variant of oral squamous cell carcinoma. J Nat Sci Biol Med. 2015;6:245–7.PubMedPubMedCentralCrossRefGoogle Scholar
  98. 98.
    Nainani P, Singh HP, Paliwal A, Nagpal N. A rare case report of clear cell variant of oral squamous cell carcinoma. J Clin Diagn Res. 2014;8:QD07–9.PubMedPubMedCentralGoogle Scholar
  99. 99.
    Frazier JJ, Sacks H, Freedman PD. Primary glycogen-rich clear cell squamous cell carcinoma of the mandibular gingiva. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e47–51.PubMedCrossRefPubMedCentralGoogle Scholar
  100. 100.
    Datar UV, Kale A, Mane D. Oral carcinoma cuniculatum: a new entity in the clinicopathological spectrum of oral squamous cell carcinoma. J Clin Diagn Res. 2017;11:ZD37–9.PubMedPubMedCentralGoogle Scholar
  101. 101.
    Thavaraj S, Cobb A, Kalavrezos N, Beale T, Walker DM, Jay A. Carcinoma cuniculatum arising in the tongue. Head Neck Pathol. 2013;6:130–4.CrossRefGoogle Scholar
  102. 102.
    Goh GH, Venkateswaran K, Leow PC, Loh KS, Thamboo TP, Petersson F. Carcinoma cuniculatum of the esophagus and tongue: report of two cases, including TP53 mutational analysis. Head Neck Pathol. 2014;8:261–8.PubMedPubMedCentralCrossRefGoogle Scholar
  103. 103.
    D’Souza G, Carey TE, William WN, Nguyen ML, Ko EC, Riddell J, Pai SI, Gupta V, Walline HM, Lee JJ, Wolf WT, Shin DM, Grandis JR, Ferris RL. Epidemiology of head and neck squamous cell cancer among HIV-infected patients. J Acquir Immune Defic Syndr. 2014;65:603–10.PubMedPubMedCentralCrossRefGoogle Scholar
  104. 104.
    Beachler DC, Abraham AG, Silverberg MJ, Jing Y, Fakhry C, Gill MJ, Kitahata MM, Klein MB, Burchell AN, Korthuis PT, Moore RD, D'Souza G. Incidence and risk factors of HPV-related and HPV-unrelated head and neck squamous cell carcinoma in HIV-infected individuals. Oral Oncol. 2017;50:1169–76.CrossRefGoogle Scholar
  105. 105.
    Mehrad M, Carpenter DH, Chernock RD, Wang H, Ma XJ, Luo Y, Luo J, Lewis JS, El-Mofty SK. Papillary squamous cell carcinoma of the head and neck: clinicopathologic and molecular features with special reference to human papillomavirus. Am J Surg Pathol. 2013;37:1349–56.PubMedPubMedCentralCrossRefGoogle Scholar
  106. 106.
    Jo VY, Mills SE, Stoler MH, Stelow EB. Papillary squamous cell carcinoma of the head and neck: frequent association with human papillomavirus infection and invasive carcinoma. Am J Surg Pathol. 2009;33:1720–4.PubMedPubMedCentralCrossRefGoogle Scholar
  107. 107.
    Fitzpatrick SG, Neuman AN, Cohen DM, Bhattacharyya I. Papillary variant of squamous cell carcinoma arising on the gingiva: 61 cases reported from within a larger series of gingival squamous cell carcinoma. Head Neck Pathol. 2013;7:320–6.PubMedPubMedCentralCrossRefGoogle Scholar
  108. 108.
    Terada T. Papillary squamous cell carcinoma of the mandibular gingiva. Int J Clin Exp Pathol. 2012;5:707–9.PubMedPubMedCentralGoogle Scholar
  109. 109.
    Terada T. Papillary squamous cell carcinoma of the oral cavity with acantholytic and pseudovascular features. Int J Clin Exp Pathol. 2011;4:794–6.PubMedPubMedCentralGoogle Scholar
  110. 110.
    Ding Y, Ma L, Shi L, Feng J, Liu W, Zhou Z. Papillary squamous cell carcinoma of the oral mucosa: a clinicopathologic and immunohistochemical study of 12 cases and literature review. Ann Diagn Pathol. 2013;17:18–21.PubMedCrossRefGoogle Scholar
  111. 111.
    Sarioglu S, Dogan E, Sahin Y, Uzun E, Bekis R, Ada E, Sagot O, Akman F. Undifferentiated laryngeal carcinoma with pagetoid spread. Head Neck Pathol. 2016;10:252–5.PubMedCrossRefGoogle Scholar
  112. 112.
    Tan T, Jennings T, Carlson JA. Dedifferentiated salivary hybrid carcinoma of the maxillary sinus with pagetoid spread to the overlying lining mucosa. Head Neck Pathol. 2015;9:293–9.CrossRefGoogle Scholar
  113. 113.
    Vidyavathi K, Prasad C, Kumar HM, Deo R. Pseudovascular adenoid squamous cell carcinoma of oral cavity: a mimicker of angiosarcoma. J Oral Maxillofac Pathol. 2012;16:288–90.PubMedPubMedCentralCrossRefGoogle Scholar
  114. 114.
    Zidar N, Gale N, Zupevc A, Dovsak D. Pseudovascular adenoid squamous-cell carcinoma of the oral cavity–a report of two cases. J Clin Pathol. 2006;59:1206–8.PubMedPubMedCentralCrossRefGoogle Scholar
  115. 115.
    Bavle RM, Govinda G, Venkataramanaiah PG, Muniswamappa S, Venugopal R. Fallacious carcinoma- spindle cell variant of squamous cell carcinoma. J Clin Diagn Res. 2016.  https://doi.org/10.7860/JCDR/2016/16400.8099.
  116. 116.
    Reyes M, Pennacchiotti G, Valdes F, Montes R, Veloso M, Matamala MA, Zanolli L, Rojas-Alcayaga G. Sarcomatoid (spindle cell) carcinoma of tongue: a report of two cases. Case Rep Dent. 2015.  https://doi.org/10.1155/2015/780856.
  117. 117.
    Romañach MJ, Azevedo RS, Carlos R, de Almeida OP, Pires FR. Clinicopathological and immunohistochemical features of oral spindle cell carcinoma. J Oral Pathol Med. 2010;39:335–41.PubMedCrossRefGoogle Scholar
  118. 118.
    Watson RF, Chernock RD, Wang X, Liu W, Ma XJ, Luo Y, Wang H, El-Mofty SK, Lewis JS Jr. Spindle cell carcinomas of the head and neck rarely harbor transcriptionally-active human papillomavirus. Head Neck Pathol. 2013;7:250–7.PubMedPubMedCentralCrossRefGoogle Scholar
  119. 119.
    Bice TC, Tran V, Merkley MA, Newlands SD, van der Sloot PG, Wu S, Miller MC. Disease-specific survival with spindle cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 2015;153:973–80.PubMedCrossRefGoogle Scholar
  120. 120.
    Gerry D, Fritsch VA, Lentsch EJ. Spindle cell carcinoma of the upper aerodigestive tract: an analysis of 341 cases with comparison to conventional squamous cell carcinoma. Ann Otol Rhinol Laryngol. 2014;123:576–83.PubMedPubMedCentralCrossRefGoogle Scholar
  121. 121.
    Terada T. Verrucous carcinoma of the oral cavity: a histopathologic study of 10 Japanese cases. J Maxillofac Oral Surg. 2011;10:148–51.PubMedPubMedCentralCrossRefGoogle Scholar
  122. 122.
    Candau-Alvarez A, Dean-Ferrer A, Alamillos-Granados FJ, Heredero-Jung S, García-García B, Ruiz-Masera JJ, Arévalo-Arévalo R, Zafra-Camacho F, Valenzuela-Salas B. Verrucous carcinoma of the oral mucosa: An epidemiological and follow-up study of patients treated with surgery in 5 last years. Med Oral Patol Oral Cir Bucal. 2014;19:e506–11.PubMedPubMedCentralCrossRefGoogle Scholar
  123. 123.
    Odar K, Kocjan BJ, Hošnjak L, Gale N, Poljak M, Zidar N. Verrucous carcinoma of the head and neck – not a human papillomavirus-related tumour? J Cell Mol Med. 2014;18:635–45.PubMedCrossRefGoogle Scholar
  124. 124.
    Terada T. Squamous cell carcinoma arising within verrucous carcinoma of the oral cavity: a case report. Int J Clin Exp Pathol. 2012;5:363–6.PubMedPubMedCentralGoogle Scholar
  125. 125.
    Patel KR, Chernock RD, Sinha P, Müller S, El-Mofty SK, Lewis JS. Verrucous carcinoma with dysplasia or minimal invasion: a variant of verrucous carcinoma with extremely favorable prognosis. Head Neck Pathol. 2015;9:65–73.PubMedCrossRefGoogle Scholar
  126. 126.
    Wakeham K, Johnston WT, Nalwoga A, Webb EL, Mayanja BN, Miley W, Elliott AM, Whitby D, Newton R. Trends in Kaposi’s sarcoma-associated Herpesvirus antibodies prior to the development of HIV-associated Kaposi's sarcoma: a nested case-control study. Int J Cancer. 2015;136:2822–30.PubMedCrossRefGoogle Scholar
  127. 127.
    Douglas JL, Gustin JK, Moses AV, Dezube BJ, Pantanowitz L. Kaposi sarcoma pathogenesis: a triad of viral infection, oncogenesis and chronic inflammation. Transl Biomed. 2010;1:72.Google Scholar
  128. 128.
    Crosetti E, Succo G. Non-human immunodeficiency virus-related Kaposi’s sarcoma of the oropharynx: a case report and review of the literature. J Med Case Rep. 2013;7:293. Published online 2013 Dec 31.  https://doi.org/10.1186/1752-1947-7-293.CrossRefPubMedPubMedCentralGoogle Scholar
  129. 129.
    Kennedy-LeJeune E, Cataldo VD. Kaposi’s sarcoma of the oral cavity. N Engl J Med. 2017;376:1268.PubMedCrossRefPubMedCentralGoogle Scholar
  130. 130.
    Carvajal RD, Spencer SA, Lydiatt W. Mucosal melanoma: a clinically and biologically unique disease entity. J Natl Compr Cancer Netw. 2012;10:345–56.CrossRefGoogle Scholar
  131. 131.
    Rapini RP, Golitz LE, Greer RO Jr, Krekorian EA, Poulson T. Primary malignant melanoma of the oral cavity: a review of 177 cases. Cancer. 1985;55:1543–51.PubMedCrossRefGoogle Scholar
  132. 132.
    Takagi M, Ishikawa G, Mori W. Primary malignant melanoma of the oral cavity in Japan: with special reference to mucosal melanosis. Cancer. 1974;34:358–70.PubMedCrossRefGoogle Scholar
  133. 133.
    Aguas SC, Quarracino MC, Lence AN, Lanfranchi-Tizeira HE. Primary melanoma of the oral cavity: ten cases and review of 177 cases from the literature. Med Oral Patol Oral Cir Bucal. 2009;14:E265–E71.PubMedGoogle Scholar
  134. 134.
    Smith MH, Bhattacharyya I, Cohen DM, Islam NM, Fitzpatrick SG, Montague LJ, Damm DD, Fowler CB. Melanoma of the oral cavity: an analysis of 46 new cases with emphasis on clinical and histopathologic characteristics. Head Neck Pathol. 2016;10:298–305.PubMedPubMedCentralCrossRefGoogle Scholar
  135. 135.
    Broomhall C, Lewis MG. Malignant melanoma of the oral cavity in Ugandan Africans. Br J Surg. 1967;54:581–4.PubMedCrossRefGoogle Scholar
  136. 136.
    Klein JD, Kupferman ME. Li-Fraumeni syndrome presenting as mucosal melanoma: case report and treatment considerations. Head Neck. 2017;39:E20–2.PubMedCrossRefGoogle Scholar
  137. 137.
    Liu YS, Yang CH, Sun YF, Geng B, Yuan KF. Multivariate analysis of the prognostic factors in 230 surgically treated oral mucosal malignant melanomas. Shanghai Kou Qiamg Yi Xue. 2005;14:466–71.Google Scholar
  138. 138.
    Chatzistefanou I, Kolokythas A, Vahtsevanos K, Antoniades K. Primary mucosal melanoma of the oral cavity: current therapy and future directions. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:17–27.PubMedCrossRefGoogle Scholar
  139. 139.
    Perloff JK. Remembering Sadao Otani. Am J Cardiol. 2013;111:1537–8.PubMedCrossRefGoogle Scholar
  140. 140.
    Temam S, Mamelle G, Marandas P, Wibault P, Avril MF, Janot F, Julieron M, Schwaab G, Luboinski B. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer. 2005;103:313–9.PubMedCrossRefPubMedCentralGoogle Scholar
  141. 141.
    Meleti M, Leemans CR, de Bree R, Vescovi P, Sesenna E, van der Waal I. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck. 2008;30:1543–51.PubMedCrossRefPubMedCentralGoogle Scholar
  142. 142.
    Ahn HJ, Na II, Park YH, Cho SY, Lee BC, Lee GH, Koh JS, Lee YS, Shim YS, Kim YK, Kang HJ, Ryoo BY, Yang SH. Role of adjuvant chemotherapy in malignant mucosal melanoma of the head and neck. Oral Oncol. 2010;46:607–11.PubMedCrossRefPubMedCentralGoogle Scholar
  143. 143.
    Margolin K. The promise of molecularly targeted and immunotherapy for advanced melanoma. Curr Treat Options in Oncol. 2016 Sep;17(9):48.  https://doi.org/10.1007/s11864-016-0421-5.CrossRefGoogle Scholar
  144. 144.
    Koto M, Demizu Y, Saitoh JI, Suefuji H, Tsuji H, Okimoto T, Ohno T, Shioyama Y, Takagi R, Nemoto K, Nakano T, Kamada T, Japan Carbon-Ion Radiation Oncology Study Group. Multicenter study of carbon-ion radiation therapy for mucosal melanoma of the head and neck: subanalysis of the Japan Carbon-Ion Radiation Oncology Study Group (J-CROS) study (1402 HN). Int J Radiat Oncol Biol Phys. 2017;97:1054–60.PubMedCrossRefPubMedCentralGoogle Scholar
  145. 145.
    Bladé J, Fernández de Larrea C, Rosiñol L, Cibeira MT, Jiménez R, Powles R. Soft-tissue plasmacytomas in multiple myeloma: incidence, mechanisms of extramedullary spread, and treatment approach. J Clin Oncol. 2011;29:3805–12.PubMedCrossRefPubMedCentralGoogle Scholar
  146. 146.
    Witt C, Borges AC, Klein K, Neumann HJ. Radiographic manifestations of multiple myeloma in the mandible: a retrospective study of 77 patients. J Oral Maxillofac Surg. 1997;55:450–3.PubMedCrossRefPubMedCentralGoogle Scholar
  147. 147.
    Sreeja C, Vijayabanu B, Vijayalakshmi D, Devi M, Ramakrishnan K, Dhivya K. Multiple myeloma involving mandible: In an elderly female. J Pharm Bioallied Sci. 2015;7:S763–5.PubMedPubMedCentralCrossRefGoogle Scholar
  148. 148.
    Kasamatsu A, Kimura Y, Tsujimura H, Kanazawa H, Koide N, Miyamoto I, Endo-Sakamoto Y, Shiiba M, Tanzawa H, Uzawa K. Maxillary swelling as the first evidence of multiple myeloma. Case Rep Dent. 2015;2015:439536.  https://doi.org/10.1155/2015/439536.CrossRefPubMedPubMedCentralGoogle Scholar
  149. 149.
    Goetze E, Walter C, Kämmerer PW. Osseous plasma cell neoplasm of the mandible for initial diagnosis of multiple myeloma: case report and literature review. J Maxillofac Oral Surg. 2015;14:469–74.PubMedCrossRefPubMedCentralGoogle Scholar
  150. 150.
    Ramaiah KK, Joshi V, Thayi SR, Sathyanarayana P, Patil P, Ahmed Z. Multiple myeloma presenting with a maxillary lesion as the first sign. Imaging Sci Dent. 2015;45:55–60.PubMedPubMedCentralCrossRefGoogle Scholar
  151. 151.
    Wei H, Pinting L, Enyi T, Zhiyong W. Initial finding of mandible mass in multiple myeloma. J Craniofac Surg. 2012;23:e599–600.PubMedCrossRefGoogle Scholar
  152. 152.
    Vallet S, Podar K. New insights, recent advances, and current challenges in the biological treatment of multiple myeloma. Expert Opin Biol Ther. 2013;13:S35–53.PubMedCrossRefGoogle Scholar
  153. 153.
    Highsmith KN, Chen SE, Horowitz S. Carfilzomib and pomalidomide: recent advances in the treatment of multiple myeloma. Pharmacotherapy. 2014;34:927–40.PubMedCrossRefGoogle Scholar
  154. 154.
    Campisi G, Fedele S, Fusco V, Pizzo G, Di Fede O, Bedogni A. Epidemiology, clinical manifestations, risk reduction and treatment strategies of jaw osteonecrosis in cancer patients exposed to antiresorptive agents. Future Oncol. 2014;10:257–75.PubMedCrossRefGoogle Scholar
  155. 155.
    Vescovi P, Nammour S. Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ) therapy. A critical review. Minerva Stomatol. 2010;59:181–203–204–13.Google Scholar
  156. 156.
    Lazaridou MN, Katopodi T, Dimitrakopoulos I. Gorlin-Goltz syndrome: a 25-year follow-up of a familial case. Oral Maxillofac Surg. 2015;19:79–84.PubMedCrossRefGoogle Scholar
  157. 157.
    Onodera S, Saito A, Hasegawa D, Morita N, Watanabe K, Nomura T, Shibahara T, Ohba S, Yamaguchi A, Azuma T. Multi-layered mutation in hedgehog-related genes in Gorlin syndrome may affect the phenotype. PLoS One. 2017;12(9):e0184702.  https://doi.org/10.1371/journal.pone.0184702.CrossRefPubMedPubMedCentralGoogle Scholar
  158. 158.
    Bresler SC, Padwa BL, Granter SR. Nevoid basal cell carcinoma syndrome (Gorlin syndrome). Head Neck Pathol. 2016;10:119–24.PubMedPubMedCentralCrossRefGoogle Scholar
  159. 159.
    de Santana ST, Vajgel A, Martins-Filho PR, de Albuquerque Maranhao Filho AW, De Holanda Vasconcellos RJ, Frota R, Filho JR. Nevoid Basal cell carcinoma syndrome: A long-term study in a family. Craniomaxillofac Trauma Reconstr. 2016;9:94–104.Google Scholar
  160. 160.
    Koutlas IG, Koch CA, Vickers RA, Brouwers FM, Vortmeyer AO. An unusual ostensible example of intraoral basal cell carcinoma. J Cutan Pathol. 2009;36:464–70.PubMedCrossRefPubMedCentralGoogle Scholar
  161. 161.
    Lazaridou MN, Dimitrakopoulos I, Tilaveridis I, Iliopoulos C, Heva A. Basal cell carcinoma arising in association with a maxillary keratocyst in a patient with Gorlin-Goltz syndrome. Report of a case. Oral Maxillofac Surg. 2012;16:127–31.PubMedCrossRefPubMedCentralGoogle Scholar
  162. 162.
    Ridge JA, Lydiatt WM, Patel SG, Glastonbury CM, Brandwein-Gensler M, Ghossein RA, Shah JP. Lip and oral cavity. In: Amin MB et al., editors. AJCC cancer stagin manual. 8th ed. 2016; p. 79–101.Google Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Margaret S. Brandwein-Weber
    • 1
  1. 1.Mount Sinai HospitalNew YorkUSA

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