The liver is designed to maintain the body’s chemical and metabolic homeostasis. It plays a major role in protein, carbohydrate, lipid, bile acid, and iron metabolism, and the body’s immune defense. About 90% of the body’s nutrients pass through the liver from the intestines. The liver is also responsible for the synthesis of many plasma proteins with different functions, and acts as a filter to remove harmful substances from the blood. Finally, it performs important endocrine functions. Knowledge of the relationship between structure and function of the liver under normal conditions is essential for understanding derangements observed in clinical diseases affecting the liver.
KeywordsLiver Protein metabolism Fat metabolism Carbohydrate metabolism Bile acid metabolism Iron metabolism Detoxification
- 4.Jamieson GG. The anatomy of general surgical operations. 2nd ed. Edinburgh/New York: Churchill Livingstone/Elsevier; 2006. p. 8–23.Google Scholar
- 8.Sherlock S. Assessment of liver function. In: Sherlock S, editor. Disease of liver and biliary system. 10th ed. London: Blackwell Science Ltd; 1997. p. 17–32.Google Scholar
- 11.Kadowaki M, Kanazawa T. Amino acids as regulators of proteolysis. J Nutr. 2003;133(6 Suppl 1):20525–65.Google Scholar
- 24.Zakhari S. Overview: How is alcohol metabolized by the body? Alcohol Res Health. 2006;30:709–19.Google Scholar