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Other Potentially Life-Threatening Conditions with Mucocutaneous Findings (Leptospirosis, Typhoid Fever, Dengue, Diphtheria, Murine Typhus)

  • Brett Lee
  • Emily Rose
Chapter

Abstract

There are several conditions with mucocutaneous findings that are potentially life-threatening, particularly in certain vulnerable populations. In this chapter, leptospirosis, typhoid fever, dengue, diphtheria, and murine typhus are reviewed. The disease time course of classic and atypical presentations is detailed to assist making the diagnosis in subtle cases. Associated symptoms are discussed as well as a comparison with disease mimics and differential diagnoses. Key diagnostic features are emphasized, and evidence-based management of each condition is detailed in this chapter.

Keywords

Leptospirosis Typhoid fever Dengue Diphtheria Murine typhus 

References

  1. 1.
    Haake DA, Levett PN. Leptospirosis in humans. Curr Top Microbiol Immunol. 2015;387:65–97.PubMedPubMedCentralGoogle Scholar
  2. 2.
    Jesus MS, Silva LA, Lima KM, Fernandes OC. Cases distribution of leptospirosis in City of Manaus, State of Amazonas, Brazil, 2000-2010. Rev Soc Bras Med Trop. 2012;45(6):713–6.CrossRefPubMedGoogle Scholar
  3. 3.
    Morgan J, Bornstein SL, Karpati AM, et al. Outbreak of leptospirosis among triathlon participants and community residents in Springfield, Illinois, 1998. Clin Infect Dis. 2002;34(12):1593–9.CrossRefPubMedGoogle Scholar
  4. 4.
    Stone SC, Mcnutt E. Update: outbreak of acute febrile illness among athletes participating in Eco-Challenge-Sabah 2000 – Borneo, Malaysia, 2000. Ann Emerg Med. 2001;38(1):83–4.CrossRefPubMedGoogle Scholar
  5. 5.
    Radl C, Müller M, Revilla-fernandez S, et al. Outbreak of leptospirosis among triathlon participants in Langau, Austria, 2010. Wien Klin Wochenschr. 2011;123(23–24):751–5.CrossRefPubMedGoogle Scholar
  6. 6.
    Brockmann S, Piechotowski I, Bock-hensley O, et al. Outbreak of leptospirosis among triathlon participants in Germany, 2006. BMC Infect Dis. 2010;10:91.CrossRefPubMedPubMedCentralGoogle Scholar
  7. 7.
    Rathinam SR. Ocular manifestations of leptospirosis. J Postgrad Med. 2005;51(3):189–94.PubMedGoogle Scholar
  8. 8.
    Gochenour WS, Smadel JE, Jackson EB, Evans LB, Yager RH. Leptospiral etiology of Fort Bragg fever. Public Health Rep. 1952;67(8):811–3.CrossRefPubMedPubMedCentralGoogle Scholar
  9. 9.
    Sanford JP. Leptospirosis – time for a booster. N Engl J Med. 1984;310(8):524–5.CrossRefPubMedGoogle Scholar
  10. 10.
    Gulati S, Gulati A. Pulmonary manifestations of leptospirosis. Lung India. 2012;29(4):347–53.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Gouveia EL, Metcalfe J, De carvalho AL, et al. Leptospirosis-associated severe pulmonary hemorrhagic syndrome, Salvador, Brazil. Emerging Infect Dis. 2008;14(3):505–8.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Limmathurotsakul D, Turner EL, Wuthiekanun V, et al. Fool’s gold: why imperfect reference tests are undermining the evaluation of novel diagnostics: a reevaluation of 5 diagnostic tests for leptospirosis. Clin Infect Dis. 2012;55(3):322–31.CrossRefPubMedPubMedCentralGoogle Scholar
  13. 13.
    Suputtamongkol Y, Niwattayakul K, Suttinont C, et al. An open, randomized, controlled trial of penicillin, doxycycline, and cefotaxime for patients with severe leptospirosis. Clin Infect Dis. 2004;39(10):1417–24.CrossRefPubMedGoogle Scholar
  14. 14.
    Guerrier G, D’ortenzio E. The Jarisch-Herxheimer reaction in leptospirosis: a systematic review. PLoS One. 2013;8(3):e59266.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ. Typhoid fever. N Engl J Med. 2002;347(22):1770–82.CrossRefPubMedGoogle Scholar
  16. 16.
    Hoffman SL, Punjabi NH, Kumala S, et al. Reduction of mortality in chloramphenicol-treated severe typhoid fever by high-dose dexamethasone. N Engl J Med. 1984;310(2):82–8.CrossRefPubMedGoogle Scholar
  17. 17.
    Haq SA, Alam MN, Hossain SM, Ahmed T, Tahir M. Value of clinical features in the diagnosis of enteric fever. Bangladesh Med Res Counc Bull. 1997;23(2):42–6.PubMedGoogle Scholar
  18. 18.
    Bal SK, Czarnowski C. A man with fever, cough, diarrhea and a coated tongue. CMAJ. 2004;170(7):1095.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Gupta SP, Gupta MS, Bhardwaj S, Chugh TD. Current clinical patterns of typhoid fever: a prospective study. J Trop Med Hyg. 1985;88(6):377–81.PubMedGoogle Scholar
  20. 20.
    Ali G, Rashid S, Kamli MA, Shah PA, Allaqaband GQ. Spectrum of neuropsychiatric complications in 791 cases of typhoid fever. Tropical Med Int Health. 1997;2(4):314–8.CrossRefGoogle Scholar
  21. 21.
    Huang DB, Dupont HL. Problem pathogens: extra-intestinal complications of Salmonella enterica serotype Typhi infection. Lancet Infect Dis. 2005;5(6):341–8.CrossRefPubMedGoogle Scholar
  22. 22.
    Hoffman SL, Punjabi NH, Rockhill RC, Sutomo A, Rivai AR, Pulungsih SP. Duodenal string-capsule culture compared with bone-marrow, blood, and rectal-swab cultures for diagnosing typhoid and paratyphoid fever. J Infect Dis. 1984;149(2):157–61.CrossRefPubMedGoogle Scholar
  23. 23.
    Thaver D, Zaidi AK, Critchley J, Madni SA, Bhutta ZA. Fluoroquinolones for treating typhoid and paratyphoid fever (enteric fever). Cochrane Database Syst Rev. 2005;(2):CD004530.Google Scholar
  24. 24.
    Kalra SP, Naithani N, Mehta SR, Swamy AJ. Current trends in the management of typhoid fever. Med J Armed Forces India. 2003;59(2):130–5.CrossRefPubMedPubMedCentralGoogle Scholar
  25. 25.
    Butler T, Islam A, Kabir I, Jones PK. Patterns of morbidity and mortality in typhoid fever dependent on age and gender: review of 552 hospitalized patients with diarrhea. Rev Infect Dis. 1991;13(1):85–90.CrossRefPubMedGoogle Scholar
  26. 26.
    Cooles P. Adjuvant steroids and relapse of typhoid fever. J Trop Med Hyg. 1986;89(5):229–31.PubMedGoogle Scholar
  27. 27.
    Guzman MG, Harris E. Dengue. Lancet. 2015;385(9966):453–65.CrossRefPubMedGoogle Scholar
  28. 28.
    Gubler DJ. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev. 1998;11(3):480–96.PubMedPubMedCentralGoogle Scholar
  29. 29.
    Kalayanarooj S, Vaughn DW, Nimmannitya S, et al. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 1997;176(2):313–21.CrossRefPubMedGoogle Scholar
  30. 30.
    Chhour YM, Ruble G, Hong R, et al. Hospital-based diagnosis of hemorrhagic fever, encephalitis, and hepatitis in Cambodian children. Emerging Infect Dis. 2002;8(5):485–9.CrossRefPubMedPubMedCentralGoogle Scholar
  31. 31.
    Solomon T, Dung NM, Vaughn DW, et al. Neurological manifestations of dengue infection. Lancet. 2000;355(9209):1053–9.CrossRefPubMedGoogle Scholar
  32. 32.
    Carod-artal FJ, Wichmann O, Farrar J, Gascón J. Neurological complications of dengue virus infection. Lancet Neurol. 2013;12(9):906–19.CrossRefPubMedGoogle Scholar
  33. 33.
    Neeraja M, Iakshmi V, Teja VD, et al. Unusual and rare manifestations of dengue during a dengue outbreak in a tertiary care hospital in South India. Arch Virol. 2014;159(7):1567–73.CrossRefPubMedGoogle Scholar
  34. 34.
    Cao XT, Ngo TN, Wills B, et al. Evaluation of the World Health Organization standard tourniquet test and a modified tourniquet test in the diagnosis of dengue infection in Viet Nam. Tropical Med Int Health. 2002;7(2):125–32.CrossRefGoogle Scholar
  35. 35.
    Guzman MG, Jaenisch T, Gaczkowski R, et al. Multi-country evaluation of the sensitivity and specificity of two commercially-available NS1 ELISA assays for dengue diagnosis. PLoS Negl Trop Dis. 2010;4(8):e811.CrossRefPubMedPubMedCentralGoogle Scholar
  36. 36.
    Hunsperger EA, Muñoz-jordán J, Beltran M, et al. Performance of dengue diagnostic tests in a single-specimen diagnostic algorithm. J Infect Dis. 2016;214(6):836–44.CrossRefPubMedGoogle Scholar
  37. 37.
    Rajapakse S, Rodrigo C, Rajapakse A. Treatment of dengue fever. Infect Drug Resist. 2012;5:103–12.CrossRefPubMedPubMedCentralGoogle Scholar
  38. 38.
    Thomas L, Kaidomar S, Kerob-bauchet B, et al. Prospective observational study of low thresholds for platelet transfusion in adult dengue patients. Transfusion. 2009;49(7):1400–11.CrossRefPubMedGoogle Scholar
  39. 39.
    Khan assir MZ, Kamran U, Ahmad HI, et al. Effectiveness of platelet transfusion in dengue fever: a randomized controlled trial. Transfus Med Hemother. 2013;40(5):362–8.PubMedPubMedCentralGoogle Scholar
  40. 40.
    English PC. Diphtheria and theories of infectious disease: centennial appreciation of the critical role of diphtheria in the history of medicine. Pediatrics. 1985;76(1):1–9.PubMedGoogle Scholar
  41. 41.
    Naiditch MJ, Bower AG. Diphtheria; a study of 1,433 cases observed during a ten-year period at the Los Angeles County hospital. Am J Med. 1954;17(2):229–45.CrossRefPubMedGoogle Scholar
  42. 42.
    Moore LSP, Leslie A, Meltzer M, Sandison A, Efstratiou A, Sriskandan S. Corynebacterium ulcerans cutaneous diphtheria. Lancet Infect Dis. 2015;15(9):1100–7.CrossRefPubMedGoogle Scholar
  43. 43.
    Höfler W. Cutaneous diphtheria. Int J Dermatol. 1991;30(12):845–7.CrossRefPubMedGoogle Scholar
  44. 44.
    Zeegelaar JE, Faber WR. Imported tropical infectious ulcers in travelers. Am J Clin Dermatol. 2008;9(4):219–32.CrossRefPubMedGoogle Scholar
  45. 45.
    Murphy JR. Corynebacterium Diphtheriae. In: Baron S, editor. Medical microbiology. 4th ed. Galveston: University of Texas Medical Branch at Galveston; 1996. Chapter 32. Available from: https://www.ncbi.nlm.nih.gov/books/NBK7971/.Google Scholar
  46. 46.
    Walters RF. Diphtheria presenting in the accident and emergency department. Arch Emerg Med. 1987;4(1):47–51.CrossRefPubMedPubMedCentralGoogle Scholar
  47. 47.
    Kneen R, Pham NG, Solomon T, et al. Penicillin vs. erythromycin in the treatment of diphtheria. Clin Infect Dis. 1998;27(4):845–50.CrossRefPubMedGoogle Scholar
  48. 48.
    Kneen R, Nguyen MD, Solomon T, et al. Clinical features and predictors of diphtheritic cardiomyopathy in Vietnamese children. Clin Infect Dis. 2004;39(11):1591–8.CrossRefPubMedGoogle Scholar
  49. 49.
    Sanghi V. Neurologic manifestations of diphtheria and pertussis. Handb Clin Neurol. 2014;121:1355–9.CrossRefPubMedGoogle Scholar
  50. 50.
    Efstratiou A, Engler KH, Mazurova IK, Glushkevich T, Vuopio-varkila J, Popovic T. Current approaches to the laboratory diagnosis of diphtheria. J Infect Dis. 2000;181(Suppl 1):S138–45.CrossRefPubMedGoogle Scholar
  51. 51.
    American Academy of Pediatrics. Diphtheria. In: Kimberlin DW, Brady MT, Jackson MA, Long SS, editors. Red book: 2015 Report of the Committee on infectious diseases. 30th ed. Elk Grove Village: American Academy of Pediatrics; 2015. p. 307–11, 770–771.Google Scholar
  52. 52.
    Civen R, Ngo V. Murine typhus: an unrecognized suburban vector-borne disease. Clin Infect Dis. 2008;46(6):913–8.CrossRefPubMedGoogle Scholar
  53. 53.
    Gorchynski JA, Langhorn C, Simmons M, Roberts D. What’s hot, with spots and red all over? Murine typhus. West J Emerg Med. 2009;10(3):207.CrossRefPubMedPubMedCentralGoogle Scholar
  54. 54.
    Tsioutis C, Zafeiri M, Avramopoulos A, Prousali E, Miligkos M, Karageorgos SA. Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: a systematic review. Acta Trop. 2017;166:16–24.CrossRefPubMedGoogle Scholar
  55. 55.
    Peniche lara G, Dzul-rosado KR, Zavala velázquez JE, Zavala-castro J. Murine typhus: clinical and epidemiological aspects. Colomb Med. 2012;43(2):175–80.PubMedPubMedCentralGoogle Scholar
  56. 56.
    Fergie JE, Purcell K, Wanat D. Murine typhus in South Texas children. Pediatr Infect Dis J. 2000;19(6):535–8.CrossRefPubMedGoogle Scholar
  57. 57.
    Lin CY, Nan-Chang C, Lee CM. Leptospirosis after Typhoon Americal. J Trop Med Hyg. 2012;86(2):187–8.CrossRefGoogle Scholar
  58. 58.
    Thomas EA, Mary J, Kanish B. Mucocutaneous manifestations of dengue fever. Indian J Dermatol. 2010;55(1):79–85.CrossRefPubMedPubMedCentralGoogle Scholar
  59. 59.
    Kenzaka T, Kumabe A. Skin rash from dengue fever. BMJ Case Rep. 2013;2013:bcr2013201598.  https://doi.org/10.1136/bcr-2013-201598.CrossRefPubMedPubMedCentralGoogle Scholar
  60. 60.
    Simmons CP, Farra JJ, van Vinh Chau N, Wills B. Dengue. N Engl J Med. 2012;366:1423–32.CrossRefPubMedGoogle Scholar
  61. 61.
    Kadirova R, Kartoglu HU, Strebel PM. Clinical characteristics and management of 676 hospitalized cases, Kyrgyz Republic, 1995. J Infect Dis. 2000;181(Suppl 1):S110–5.CrossRefPubMedGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Emergency MedicineLos Angeles County + University of Southern California Medical CenterLos AngelesUSA
  2. 2.Department of Emergency MedicineKeck School of Medicine of the University of Southern California, Los Angeles County + USC Medical CenterLos AngelesUSA

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