The Role of Secreted Serine Proteases of the Host in Influenza Viral Pathogenesis
Influenza A virus (IAV) is one of the most common pathogens causing acute respiratory infections in humans of all age group. IAV infectivity depends on activation of the viral hemagglutinin by proteolytic enzymes of the host, among which secreted trypsin-type serine proteases play a prominent role. Proinflammatory cytokines induced in influenza virus infections upregulate production of the proteases and, thus, enhance virus replication, tissue damage, and metabolic disorders. Application of protease inhibitors counteracting these effects is therefore a promising therapeutic regimen against influenza.
KeywordsInfluenza virus Sendai virus Trypsin-type serine proteases Cytokines Multiple organ failure
Our studies were supported in part by grants-in-aid #16H05348 and the Special Coordination Funds for Promoting Science and Technology of the Ministry of Education, Culture, Sports, Science and Technology of Japan and by Health and Labour Sciences Research Grants (grant #12103307) from the Ministry of Health, Labour and Welfare of Japan.
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