The Anterior Insula and Its Relationship to Autism

  • Seong-Jin Moon
  • Lara Tkachenko
  • Erick Garcia-Gorbea
  • R. Shane Tubbs
  • Marc D. Moisi


Autism spectrum disorders are primarily identified by impairment in the social setting with either interaction or communication difficulty. The anterior insula may play a role in the neural connections that predispose to ASD. Its anatomical location provides a central hub that can receive both direct and indirect projections and concurrently send out signals, notably from the thalamus and amygdala. This was demonstrated notably through functional MRI. Future research direction on anterior insula and its relationship to autism can focus on functional connectivity, anatomical basis, and hypoactivity versus hyperactivity.


Autism spectrum disorder Anterior insula Connectivity Salience processing 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Seong-Jin Moon
    • 1
  • Lara Tkachenko
    • 2
  • Erick Garcia-Gorbea
    • 1
  • R. Shane Tubbs
    • 2
  • Marc D. Moisi
    • 1
    • 2
  1. 1.Department of NeurosurgeryWayne State UniversityDetroitUSA
  2. 2.Seattle Science FoundationSeattleUSA

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