Advertisement

Lateralization of the Insular Cortex

  • Michael J. Montalbano
  • R. Shane Tubbs
Chapter

Abstract

The insula functions primarily to integrate interoceptive and viscerosensory input. These functions are lateralized and can broadly be separated into positive or negative emotional valence, approach or avoidance behaviors, perception or experience of a certain phenomenon, as well as conscious perception of one’s own affective state. This also includes monitoring of autonomic functions, emotional and cognitive processing, and a role in language production. Further studies are needed to clearly demarcate boundaries in persons differing in gender, handedness, or a possible psychiatric disorder.

Keywords

Insula Lateralization Language Emotion Cognition 

References

  1. 1.
    Touroutoglou A, Hollenbeck M, Dickerson BC, et al. Dissociable large-scale networks anchored in the right anterior insula subserve affective experience and attention. Neuroimage. 2012;60(4):1947–58.CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Craig AD. Forebrain emotional asymmetry: a neuroanatomical basis? Trends Cogn Sci. 2005;9(12):566–71.CrossRefPubMedGoogle Scholar
  3. 3.
    Duerden E, Arsalidou M, Lee M, et al. Lateralization of affective processing in the insula. Neuroimage. 2013;78:159–75.CrossRefPubMedGoogle Scholar
  4. 4.
    Caria A, Veit R, Sitaram R, et al. Regulation of anterior insular cortex activity using real-time fMRI. Neuroimage. 2007;35:1238–46.CrossRefPubMedGoogle Scholar
  5. 5.
    Kuhtz-Buschbeck JP, van der Horst C, Wolff S, et al. Activation of the supplementary motor area (SMA) during voluntary pelvic floor muscle contractions: an fMRI study. Neuroimage. 2007;35:449–57.CrossRefPubMedGoogle Scholar
  6. 6.
    Kuhtz-Buschbeck JP, van der Horst C, Pott C, Wolff S, et al. Cortical representation of the urge to void: a functional magnetic resonance imaging study. J Urol. 2009;174:1477–81.CrossRefGoogle Scholar
  7. 7.
    Zaki J, Davis JI, Ochsner KN. Overlapping activity in anterior insula during interoception and emotional experience. Neuroimage. 2012;62:493–9.CrossRefPubMedGoogle Scholar
  8. 8.
    Caria A, Sitaram R, Veit R, et al. Volitional control of anterior insula activity modulates the response to aversive stimuli. a real-time functional magnetic resonance imaging study. Biol Psychiatry. 2010;68:425–32.CrossRefPubMedGoogle Scholar
  9. 9.
    James W. What is an emotion? Mind. 1884;9(34):188–205.CrossRefGoogle Scholar
  10. 10.
    Kann S, Zhang S, Manza P, et al. Hemispheric lateralization of resting-state functional connectivity of the anterior insula: association with age, gender, and a novelty-seeking trait. Brain Connect. 2016;6(9):724–34.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Harle KM, Chang LJ, van’t Wout M, et al. The neural mechanisms of affect infusion in social economic decision-making: a mediating role of the anterior insula. Neuroimage. 2012;61:32–40.CrossRefPubMedGoogle Scholar
  12. 12.
    Doyle-Thomas KAR, Kushki A, Duerden EG, et al. The effect of diagnosis, age, and symptom severity on cortical surface area in the cingulate cortex and insula in autism spectrum disorders. J Child Neurol. 2012;28(6):732–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Sridharan D, Levitin DJ, Menon V. A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks. PNAS. 2008;105(34):12,569–74.CrossRefGoogle Scholar
  14. 14.
    Howard LR, Kumaran D, Olafsdottir HF, et al. Double dissociation between hippocampal and parahippocampal responses to object-background context and scene novelty. J Neurosci. 2011;31(14):5253–61.CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Ullsperger M, Harsay HA, Wessel JR, et al. Conscious perception of errors and its relation to the anterior insula. Brain Struct Funct. 2010;214:629–43.CrossRefPubMedPubMedCentralGoogle Scholar
  16. 16.
    Parkes SL, Balleine BW. Incentive memory: evidence the basolateral amygdala encodes and the insular cortex retrieves outcome values to guide choice between goal-directed actions. J Neurosci. 2013;33(20):8753–63.CrossRefPubMedPubMedCentralGoogle Scholar
  17. 17.
    Kuriki S, Isahai N, Takeuchi F, et al. Where do perception and recognition of words take place in the brain? A neuromagnetic approach. Electroencephalogr Clin Neurophysiol Suppl. 1999;49:179–83.PubMedGoogle Scholar
  18. 18.
    Borovsky A, Saygin AP, Bates E, et al. Lesion correlates of conversational speech production deficits. Neuropsychologia. 2007;45(11):2525–33.CrossRefPubMedPubMedCentralGoogle Scholar
  19. 19.
    Oh A, Duerden EG, Pang EW. The role of the insula in speech and language processing. Brain Lang. 2014;135:96–103.CrossRefPubMedPubMedCentralGoogle Scholar
  20. 20.
    Fedorenko E, Fillmore P, Smith K, et al. The superior precentral gyrus of the insula does not appear to be functionally specialized for articulation. J Neurophysiol. 2015;113(7):2376–82.CrossRefPubMedPubMedCentralGoogle Scholar
  21. 21.
    Hagele C, Friedel E, Schlagenhauf F, et al. Affective responses across psychiatric disorders: a dimensional approach. Neurosci Lett. 2016;623:71–8.CrossRefPubMedGoogle Scholar
  22. 22.
    Sitaram R, Caria A, Veit R, et al. Volitional control of the anterior insula in criminal psychopaths using real-time fMRI neurofeedback: a pilot study. Front Behav Neurosci. 2014;8:344.  https://doi.org/10.3389/fnbeh.2014.00344.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Anatomical SciencesSt. George’s UniversityTrue BlueGrenada
  2. 2.Seattle Science FoundationSeattleUSA

Personalised recommendations