Assessment with Non-Cognitive Screening Instruments

  • A. J. Larner


This chapter examines the diagnostic utility of various screening instruments examining functional, behavioural and psychiatric, neurovegetative, and informant scales, collectively termed (for want of a better nomenclature) non-cognitive screening instruments, in the diagnosis of cognitive disorders. These supplement the cognitive screening instruments discussed in the previous chapter.


Dementia Diagnosis Non-cognitive screening instruments 


  1. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Cornell Scale for Depression in Dementia. Biol Psychiatry. 1988a;23:271–84.PubMedCrossRefGoogle Scholar
  2. Alexopoulos GS, Abrams RC, Young RC, Shamoian CA. Use of the Cornell scale in nondemented patients. J Am Geriatr Soc. 1988b;36:230–6.PubMedCrossRefGoogle Scholar
  3. American Psychiatric Association. Diagnostic and statistical manual of mental disorders, 4th ed., text revison (DSM-IV-TR). Washington: American Psychiatric Association; 2000.Google Scholar
  4. Arroll B, Khin N, Kerse N. Screening for depression in primary care with two verbally asked questions: cross sectional study. BMJ. 2003;327:1144–6.PubMedPubMedCentralCrossRefGoogle Scholar
  5. Backhaus J, Junghanns K, Broocks A, Riemann D, Hohagen F. Test-retest reliability and validity of the Pittsburgh Sleep Quality Index in primary insomnia. J Psychosom Res. 2002;53:737–40.PubMedCrossRefGoogle Scholar
  6. Ballard CG, O’Brien J, James I, Swann A. Dementia: management of behavioural and psychological symptoms. Oxford: Oxford University Press; 2001.Google Scholar
  7. Barberger-Gateau P, Commenges D, Gagnon M, Letenneur L, Sauvel C, Dartigues JF. Instrumental activities of daily living as a screening tool for cognitive impairment and dementia in elderly community dwellers. J Am Geriatr Soc. 1992;40:1129–34.PubMedCrossRefGoogle Scholar
  8. Bédard M, Molloy DW, Squire L, Dubois S, Lever JA, O’Donnell M. The Zarit Burden Interview: a new short version and screening version. Gerontologist. 2001;41:652–7.PubMedCrossRefGoogle Scholar
  9. Berrios GE, Hodges JR, editors. Memory disorders in psychiatric practice. Cambridge: Cambridge University Press; 2000.Google Scholar
  10. Boddy F, Rowan EN, Lett D, O’Brien JT, McKeith IG, Burn DJ. Subjectively reported sleep quality and excessive daytime somnolence in Parkinson’s disease with and without dementia, dementia with Lewy bodies and Alzheimer’s disease. Int J Geriatr Psychiatry. 2007;22:529–35.PubMedCrossRefGoogle Scholar
  11. Boeve BF, Silber MH, Saper CB, et al. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease. Brain. 2007;130:2770–88.PubMedCrossRefGoogle Scholar
  12. Bozeat S, Gregory CA, Lambon Ralph MA, Hodges JR. Which neuropsychiatric and behavioural features distinguish frontal and temporal variants of frontotemporal dementia from Alzheimer’s disease? J Neurol Neurosurg Psychiatry. 2000;69:178–86.PubMedPubMedCentralCrossRefGoogle Scholar
  13. British Medical Association. Revisions to the GMS contract 2006/07. Delivering investment in general practice. London: British Medical Association; 2006.Google Scholar
  14. Bubu OM, Brannick M, Mortimer J, et al. Sleep, cognitive impairment, and Alzheimer’s disease: a systematic review and meta-analysis. Sleep. 2017;40.
  15. Buysse DJ, Reynolds CF III, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research. Psychiatry Res. 1989;28:193–213.PubMedCrossRefGoogle Scholar
  16. Carpenter CR, DesPain B, Keeling TN, Shah M, Rothenberger M. The Six-Item Screener and AD8 for the detection of cognitive impairment in geriatric emergency department patients. Ann Emerg Med. 2011;57:653–61.PubMedCrossRefGoogle Scholar
  17. Cherbuin N, Jorm AF. The IQCODE: using informant reports to assess cognitive change in the clinic and in older individuals living in the community. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 275–95.CrossRefGoogle Scholar
  18. Chung F, Yegneswaran B, Liao P, et al. STOP questionnaire: a tool to screen patients for obstructive sleep apnea. Anesthesiology. 2008;108:812–21.PubMedCrossRefGoogle Scholar
  19. Chung F, Subramanyam R, Liao P, et al. High STOP-Bang score indicates a high probability of obstructive sleep apnoea. Br J Anaesth. 2012;108:768–75.PubMedPubMedCentralCrossRefGoogle Scholar
  20. Cole JS, Motivala SJ, Buysse DJ, Oxman MN, Levin MJ, Irwin MR. Validation of a 3-factor scoring model for the Pittsburgh Sleep Quality Index in older adults. Sleep. 2006;29:112–6.PubMedCrossRefGoogle Scholar
  21. Cullen B, O’Neill B, Evans JJ, Coen RF, Lawlor BA. A review of screening tests for cognitive impairment. J Neurol Neurosurg Psychiatry. 2007;78:790–9.PubMedPubMedCentralCrossRefGoogle Scholar
  22. Culshaw M, Larner AJ. Assessing the impact of sleep disorders on people with dementia and their caregivers. J Dement Care. 2009;17(5):38.Google Scholar
  23. Cummings JL, Mega MS, Gray K, et al. The Neuropsychiatric Inventory: comprehensive assessment of psychopathology in dementia. Neurology. 1994;44:2308–14.PubMedCrossRefGoogle Scholar
  24. Davies M, Larner AJ. Sleep-related disorders presenting in the Cognitive Function Clinic. 2009. Scholar
  25. Deakin JB, Rahman S, Nestor PJ, Hodges JR, Sahakian BJ. Paroxetine does not improve symptoms and impairs cognition in frontotemporal dementia: a double-blind randomized controlled trial. Psychopharmacology. 2004;172:400–8.PubMedCrossRefGoogle Scholar
  26. Dudas RB, Berrios GE, Hodges JR. The Addenbrooke’s Cognitive Examination (ACE) in the differential diagnosis of early dementias versus affective disorder. Am J Geriatr Psychiatry. 2005;13:218–26.PubMedPubMedCentralCrossRefGoogle Scholar
  27. Ehrensperger MM, Berres M, Taylor KI, Monsch AU. Screening properties of the German IQCODE with a two-year time frame in MCI and early Alzheimer’s disease. Int Psychogeriatr. 2010;22:91–100.PubMedCrossRefGoogle Scholar
  28. Engel GL. The need for a new medical model: a challenge to biomedicine. Science. 1977;196:129–36.PubMedCrossRefGoogle Scholar
  29. Ferman TJ, Smith GE, Boeve BF, et al. DLB fluctuations: specific features that reliably differentiate DLB from AD and normal aging. Neurology. 2004;62:181–7.PubMedCrossRefGoogle Scholar
  30. Fictenberg NL, Putnam SH, Mann NR, Zafonte RD, Millard AE. Insomnia screening in postacute traumatic brain injury: utility and validity of the Pittsburgh Sleep Quality Index. Am J Phys Med Rehabil. 2001;80:339–45.PubMedCrossRefGoogle Scholar
  31. Finkel SI, Silva JCE, Cohen G, Miller S, Sartorius N. Behavioural and psychological signs and symptoms of dementia: a consensus statement on current knowledge and implications for research and treatment. Int Psychogeriatr. 1996;8(Suppl3):497–500.PubMedGoogle Scholar
  32. Flicker L, Logiudice D, Carlin JB, Ames D. The predictive value of dementia screening instruments in clinical populations. Int J Geriatr Psychiatry. 1997;12:203–9.PubMedCrossRefGoogle Scholar
  33. Folstein MF, Folstein SE, McHugh PR. “Mini-Mental State.” A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975;12:189–98.PubMedPubMedCentralCrossRefGoogle Scholar
  34. Galvin JE, Goodyear M. Brief informant interviews to screen for dementia: the AD8 and Quick Dementia Rating System. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 297–312.CrossRefGoogle Scholar
  35. Galvin JE, Roe CM, Powlishta KK, et al. The AD8. A brief informant interview to detect dementia. Neurology. 2005;65:559–64.PubMedPubMedCentralCrossRefGoogle Scholar
  36. Galvin JE, Roe CM, Xiong C, Morris JE. Validity and reliability of the AD8 informant interview in dementia. Neurology. 2006;67:1942–8.PubMedCrossRefGoogle Scholar
  37. Galvin JE, Roe CM, Coats MA, Morris JC. Patient’s rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia. Arch Neurol. 2007;64:725–30.PubMedCrossRefGoogle Scholar
  38. Gelinas I, Gauthier L, McIntyre M, Gauthier S. Development of a functional measure for persons with Alzheimer’s disease: the Disability Assessment for Dementia. Am J Occup Ther. 1999;53:471–81.PubMedCrossRefGoogle Scholar
  39. Gentili A, Weiner DK, Kuchibhatla M, Edinger JD. Test-retest reliability of the Pittsburgh sleep quality index in nursing home residents. J Am Geriatr Soc. 1995;43:1317–8.PubMedCrossRefGoogle Scholar
  40. Ghadiri-Sani M, Larner AJ. Cognitive screening instrument use in primary care: is it changing? Clin Pract. 2014;11:425–9.CrossRefGoogle Scholar
  41. Gilbody S, Richards D, Barkham M. Diagnosing depression in primary care using self-completed instruments: UK validation of PHQ-9 and CORE-OM. Br J Gen Pract. 2007a;57:650–2.PubMedPubMedCentralGoogle Scholar
  42. Gilbody S, Richards D, Brealey S, Hewitt C. Screening for depression in medical settings with the Patient Health Questionnaire (PHQ): a diagnostic meta-analysis. J Gen Intern Med. 2007b;22:1596–602.PubMedPubMedCentralCrossRefGoogle Scholar
  43. Hancock P, Larner AJ. The diagnosis of dementia: diagnostic accuracy of an instrument measuring activities of daily living in a clinic-based population. Dement Geriatr Cogn Disord. 2007;23:133–9.PubMedPubMedCentralCrossRefGoogle Scholar
  44. Hancock P, Larner AJ. Cambridge Behavioural Inventory for the diagnosis of dementia. Prog Neurol Psychiatry. 2008;12(7):23–5.CrossRefGoogle Scholar
  45. Hancock P, Larner AJ. Clinical utility of Patient Health Questionnaire-9 (PHQ-9) in memory clinics. Int J Psychiatry Clin Pract. 2009a;13:188–91.PubMedPubMedCentralCrossRefGoogle Scholar
  46. Hancock P, Larner AJ. Diagnostic utility of the Pittsburgh Sleep Quality Index in memory clinics. Int J Geriatr Psychiatry. 2009b;24:1237–41.CrossRefPubMedGoogle Scholar
  47. Hancock P, Larner AJ. Diagnostic utility of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) and its combination with the Addenbrooke’s Cognitive Examination-Revised (ACE-R) in a memory clinic-based population. Int Psychogeriatr. 2009c;21:526–30.PubMedPubMedCentralCrossRefGoogle Scholar
  48. Hancock P, Larner AJ. Cornell Scale for Depression in Dementia: clinical utility in a memory clinic. Int J Psychiatry Clin Pract. 2015;19:71–4.PubMedCrossRefGoogle Scholar
  49. Harrison JK, Fearon P, Noel-Storr AH, McShane R, Stott DJ, Quinn TJ. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a general practice (primary care) setting. Cochrane Database Syst Rev. 2014;CD010771.Google Scholar
  50. Harrison JK, Fearon P, Noel-Storr AH, McShane R, Stott DJ, Quinn TJ. Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) for the diagnosis of dementia within a secondary care setting. Cochrane Database Syst Rev. 2015;CD010772.Google Scholar
  51. Hebert R, Bravo G, Preville M. Reliability, validity and reference values of the Zarit Burden Interview for assessing informal caregivers of community-dwelling older persons with dementia. Can J Aging. 2000;19:494–507.CrossRefGoogle Scholar
  52. Hodges JR, Larner AJ. Addenbrooke’s Cognitive Examinations: ACE, ACE-R, ACE-III, ACEapp, and M-ACE. In: Larner AJ, editor. Cognitive screening instruments. A practical approach. 2nd ed. London: Springer; 2017. p. 109–37.CrossRefGoogle Scholar
  53. Hokoishi K, Ikeda M, Maki N, et al. Interrater reliability of the Physical Self-Maintenance Scale and the Instrumental Activities of Daily Living Scale in a variety of health professional representatives. Aging Ment Health. 2001;5:38–40.PubMedCrossRefGoogle Scholar
  54. Jenkins CD, Stanton BA, Niemcryk SJ, Rose RM. A scale for the estimation of sleep problems in clinical research. J Clin Epidemiol. 1988;41:313–21.PubMedCrossRefGoogle Scholar
  55. Johns MW. A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale. Sleep. 1991;14:540–5.PubMedCrossRefGoogle Scholar
  56. Jorm AF. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): a review. Int Psychogeriatr. 2004;16:275–93.PubMedCrossRefGoogle Scholar
  57. Jorm AF, Jacomb PA. The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE): socio-demographic correlates, reliability, validity and some norms. Psychol Med. 1989;19:1015–22.PubMedCrossRefGoogle Scholar
  58. Jorm AF, Scott R, Cullen JS, MacKinnon AJ. Performance of the Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) as a screening test for dementia. Psychol Med. 1991;21:785–90.PubMedCrossRefGoogle Scholar
  59. Knapskog AB, Barca ML, Engedal K. Prevalence of depression among memory clinic patients as measured by the Cornell Scale of Depression in Dementia. Aging Ment Health. 2014;18:579–87.PubMedCrossRefGoogle Scholar
  60. Knopman DS, DeKosky ST, Cummings JL, et al. Practice parameter: Diagnosis of dementia (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology. 2001;56:1143–53.PubMedCrossRefGoogle Scholar
  61. Knutson KL, Rathouz PJ, Yan LL, Liu K, Lauderdale DS. Stability of Pittsburgh Sleep Quality Index and the Epworth Sleepiness Questionnaires over 1 year in early middle-aged adults: the CARDIA study. Sleep. 2006;29:1503–6.PubMedCrossRefGoogle Scholar
  62. Korner A, Lauritzen L, Abelskov K, Gulmann N, Marie Brodersen A, Wedervang-Jensen T, et al. The Geriatric Depression Scale and the Cornell Scale for Depression in Dementia. A validity study. Nord J Psychiatry. 2006;60:360–4.PubMedCrossRefGoogle Scholar
  63. Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med. 2001;16:606–13.PubMedPubMedCentralCrossRefGoogle Scholar
  64. Larner AJ. Obstructive sleep apnoea syndrome presenting in a neurology outpatient clinic. Int J Clin Pract. 2003;57:150–2.PubMedGoogle Scholar
  65. Larner AJ. Delirium: diagnosis, aetiopathogenesis, and treatment. Adv Clin Neurosci Rehabil. 2004;4(2):28–9.Google Scholar
  66. Larner AJ. “Who came with you?” a diagnostic observation in patients with memory problems? J Neurol Neurosurg Psychiatry. 2005a;76:1739.PubMedPubMedCentralCrossRefGoogle Scholar
  67. Larner AJ. Two simple questions in the identification of dementia. J Neurol Neurosurg Psychiatry. 2005b;76:1317. (abstract 023).CrossRefGoogle Scholar
  68. Larner AJ. Cambridge Behavioural Inventory: diagnostic and differential diagnostic utility. J Neurol Neurosurg Psychiatry. 2008a;79:351–2. (abstract 61).Google Scholar
  69. Larner AJ. Delusion of pregnancy in frontotemporal lobar degeneration with motor neurone disease (FTLD/MND). Behav Neurol. 2008b;19:199–200.PubMedPubMedCentralCrossRefGoogle Scholar
  70. Larner AJ. “Attended alone” sign: validity and reliability for the exclusion of dementia. Age Ageing. 2009;38:476–8.PubMedPubMedCentralCrossRefGoogle Scholar
  71. Larner AJ. Shift-work sleep disorder presenting in the cognitive disorders clinic. Eur J Neurol. 2010a;17(Suppl 3):213. (abstract P1359).Google Scholar
  72. Larner AJ. Can IQCODE differentiate Alzheimer’s disease and frontotemporal dementia? Age Ageing. 2010b;39:392–4.PubMedCrossRefGoogle Scholar
  73. Larner AJ. Dementia in clinical practice: a neurological perspective. Studies in the dementia clinic. London: Springer; 2012a.CrossRefGoogle Scholar
  74. Larner AJ. Can the informant Fluctuation Composite Score help in the diagnosis of synucleinopathies? A pragmatic study. Int J Geriatr Psychiatry. 2012b;27:1094–5.PubMedCrossRefGoogle Scholar
  75. Larner AJ. Delusion of pregnancy: a case revisited. Behav Neurol. 2013;27:293–4.PubMedPubMedCentralCrossRefGoogle Scholar
  76. Larner AJ. Dementia in clinical practice: a neurological perspective. Pragmatic studies in the Cognitive Function Clinic. London: Springer; 2014a.CrossRefGoogle Scholar
  77. Larner AJ. Screening utility of the “attended alone” sign for subjective memory impairment. Alzheimer Dis Assoc Disord. 2014b;28:364–5.PubMedPubMedCentralCrossRefGoogle Scholar
  78. Larner AJ. AD8 informant questionnaire for cognitive impairment: pragmatic diagnostic test accuracy study. J Geriatr Psychiatry Neurol. 2015;28:198–202.CrossRefPubMedPubMedCentralGoogle Scholar
  79. Larner AJ. Cognitive screening instruments for the diagnosis of mild cognitive impairment. Prog Neurol Psychiatry. 2016;20(2):21–6.CrossRefGoogle Scholar
  80. Larner AJ, Culshaw M. Use of the Sleep Disorders Inventory in cohort of community-dwelling patients recruited through the Alzheimer’s society. Alzheimers Dement. 2008;4(Suppl 2):T523–4. (abstract P3–025).CrossRefGoogle Scholar
  81. Larner AJ, Ghadiali EJ. Cognitive findings in central sleep apnoea syndrome. 2008. Scholar
  82. Larner AJ, Hancock P. Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology. 2008a;70:658.PubMedCrossRefGoogle Scholar
  83. Larner AJ, Hancock P. The utility of the Cambridge Behavioural Inventory in neurodegenerative disease. 2008b., Accessed 29 May 2008.Google Scholar
  84. Larner AJ, Hancock P. Does combining cognitive and functional scales facilitate the diagnosis of dementia? Int J Geriatr Psychiatry. 2012;27:547–8.PubMedCrossRefGoogle Scholar
  85. Larner AJ, Hancock P. ACE-R or MMSE? A weighted comparison. Int J Geriatr Psychiatry. 2014;29:767–8.PubMedCrossRefGoogle Scholar
  86. Larner AJ, Ziso B. Screening for obstructive sleep apnoea using the STOPBANG questionnaire. Clin Med. 2018;18:108–9.CrossRefGoogle Scholar
  87. Larner AJ, Hart IK, Cresswell P, Doran M. REM sleep behaviour disorder in the cognitive function clinic. Eur J Neurol. 2005;12(Suppl 2):218. (abstract 2211).Google Scholar
  88. Larner AJ, Ray PS, Doran M. The R269H mutation in presenilin-1 presenting as late-onset autosomal dominant Alzheimer’s disease. J Neurol Sci. 2007;252:173–6.PubMedPubMedCentralCrossRefGoogle Scholar
  89. Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969;9:179–86.PubMedCrossRefGoogle Scholar
  90. Lim R, Larner AJ. Obstructive sleep apnoea-hypopnoea syndrome presenting in the neurology clinic: a prospective 5-year study. Int J Clin Pract. 2008;62:1886–8.PubMedCrossRefGoogle Scholar
  91. Lipton AM, Marshall CD. The common sense guide to dementia for clinicians and caregivers. New York: Springer; 2013.CrossRefGoogle Scholar
  92. LittleJohn J, Dennis G, Bianchi S, Harkness K, Thiyagesh S, Blackburn D. Prevalence of sleep disorders in a memory clinic population. J Neurol Neurosurg Psychiatry. 2014;85:e4.CrossRefGoogle Scholar
  93. Lo JC, Groeger JA, Cheng GH, Dijk DJ, Chee MW. Self-reported sleep duration and cognitive performance in older adults: a systematic review and meta-analysis. Sleep Med. 2016;17:89–98.CrossRefGoogle Scholar
  94. Löwe B, Kroenke K, Herzog W, Gräfe K. Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9). J Affect Disord. 2004;81:61–6.PubMedCrossRefGoogle Scholar
  95. Löwe B, Schenkel I, Carney-Doebbeling C, Göbel C. Responsiveness of the PHQ-9 to psychopharmacological depression treatment. Psychosomatics. 2006;47:62–7.PubMedCrossRefGoogle Scholar
  96. Macedo AC, Balouch S, Tabet N. Is sleep disruption a risk factor for Alzheimer’s disease? J Alzheimers Dis. 2017;58:993–1002.PubMedCrossRefGoogle Scholar
  97. Martin A, Rief W, Klaiberg A, Braehler E. Validity of the Brief Patient Health Questionnaire Mood Scale (PHQ-9) in the general population. Gen Hosp Psychiatry. 2006;28:71–7.PubMedCrossRefGoogle Scholar
  98. Mathuranath PS, Nestor PJ, Berrios GE, Rakowicz W, Hodges JR. A brief cognitive test battery to differentiate Alzheimer’s disease and frontotemporal dementia. Neurology. 2000;55:1613–20.PubMedPubMedCentralCrossRefGoogle Scholar
  99. Menon R, Larner AJ. Use of cognitive screening instruments in primary care: the impact of national dementia directives (NICE/SCIE, National Dementia Strategy). Fam Pract. 2011;28:272–6.PubMedPubMedCentralCrossRefGoogle Scholar
  100. Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR. The Addenbrooke’s Cognitive Examination Revised: a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry. 2006;21:1078–85.PubMedCrossRefGoogle Scholar
  101. Mioshi E, Kipps CM, Dawson K, Mitchell J, Graham A, Hodges JR. Activities of daily living in frontotemporal dementia and Alzheimer disease. Neurology. 2007;68:2077–84.PubMedCrossRefGoogle Scholar
  102. Moe KE, Vitiello MV, Larsen LH, et al. Cognitive processes and sleep disturbances: sleep/wake patterns in Alzheimer’s disease; relationship with cognition and function. J Sleep Res. 1995;4:15–20.PubMedCrossRefGoogle Scholar
  103. Nagahama Y, Okina T, Suzuki N, Matsuda M. The Cambridge Behavioral Inventory: validation and application in a memory clinic. J Geriatr Psychiatry Neurol. 2006;19:220–5.PubMedCrossRefGoogle Scholar
  104. Nygård L. Instrumental activities of daily living: a stepping stone towards Alzheimer’s disease diagnosis in subjects with mild cognitive impairment? Acta Neurol Scand. 2003;107(suppl179):42–6.CrossRefGoogle Scholar
  105. Oliveira FF, Smith MA, Bertolucci PH. Comparisons among tests of cognitive assessment and functional independence in patients with Alzheimer’s disease. J Neurol. 2011;258(Suppl1):S237. (abstract P837).Google Scholar
  106. Osorio CD, Gallinaro AL, Lorenzi FG, Lage LV. Sleep quality in patients with fibromyalgia using the Pittsburgh Sleep Quality Index. J Rheumatol. 2006;33:1863–5.PubMedGoogle Scholar
  107. Osorio RS, Gumb T, Pirraglia E, et al. Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 2015;84:1964–71.PubMedPubMedCentralCrossRefGoogle Scholar
  108. Panegyres PK, Frencham K. Course and causes of suspected dementia in young adults: a longitudinal study. Am J Alzheimers Dis Other Demen. 2007;22:48–56.PubMedCrossRefGoogle Scholar
  109. Park KW, Pavlik VN, Rountree SD, Darby EJ, Doody RS. Is functional decline necessary for a diagnosis of Alzheimer’s disease? Dement Geriatr Cogn Disord. 2007;24:375–9.PubMedCrossRefGoogle Scholar
  110. Payne JD. Learning, memory, and sleep in humans. Sleep Med Clin. 2011;6:15–30.CrossRefGoogle Scholar
  111. Pfeffer RI, Kurosaki TT, Harrah CH, Chance JM, Filos S. Measurement of functional activities in older adults in the community. J Gerontol. 1982;37:323–9.PubMedCrossRefGoogle Scholar
  112. Quinn TJ, McShane R, Fearon P, Young C, Noel-Storr AH, Stott DJ. IQCODE for the diagnosis of Alzheimer’s disease dementia and other dementias within a community setting. Cochrane Database Syst Rev. 2012;CD010079.Google Scholar
  113. Rawle M, Larner A. MoCA subscores to diagnose dementia subtypes: initial study. J Neurol Neursurg Psychiatry. 2014;85:e4.CrossRefGoogle Scholar
  114. Rockwood K, Cosway S, Carver D, et al. The risk of dementia and death following delirium. Age Ageing. 1999;28:551–6.PubMedCrossRefGoogle Scholar
  115. Roose SP, Devanand DP. The interface between dementia and depression. London: Martin Dunitz; 1999.Google Scholar
  116. Savva GM, Zaccai J, Matthews FM, et al. Prevalence, correlates and course of behavioural and psychological symptoms of dementia in the population. Br J Psychiatry. 2009;194:212–9.PubMedCrossRefGoogle Scholar
  117. Schredl M, Weber B, Leins ML, Heuser I. Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons. Exp Gerontol. 2001;36:353–61.PubMedCrossRefGoogle Scholar
  118. Shastri A, Bangar S, Holmes J. Obstructive sleep apnoea and dementia: is there a link? Int J Geriatr Psychiatry. 2016;31:400–5.PubMedCrossRefGoogle Scholar
  119. Sikkes SAM, de Lange-de Klerk ESM, Pijnenburg YAL, Scheltens P, Uitdehaag BMJA. Systematic review of instrumental activities of daily living scales in dementia: room for improvement. J Neurol Neurosurg Psychiatry. 2009;80:7–12.PubMedCrossRefGoogle Scholar
  120. Sikkes SA, Knol DL, Pijnenburg YA, et al. Validation of the Amsterdam IADL questionnaire©, a new tool to measure instrumental activities of daily living in dementia. Neuroepidemiology. 2013;41:35–41.PubMedCrossRefGoogle Scholar
  121. Stagg B, Larner AJ. STOP-Bang: screening for obstructive sleep apnoea in a cognitive clinic. Eur J Neurol. 2015a;22(Suppl1):578. (abstract F1204).Google Scholar
  122. Stagg B, Larner AJ. Zarit Burden Interview: pragmatic study in a dedicated cognitive function clinic. Prog Neurol Psychiatry. 2015b;19(4):23–7.CrossRefGoogle Scholar
  123. Stiasny-Kolster K, Mayer G, Schafer S, Moller JC, Heinzel-Gutenbrunner M, Oertel WH. The REM Sleep Behavior Disorder Screening Questionnaire – a new diagnostic instrument. Mov Disord. 2007;22:2386–93.PubMedCrossRefGoogle Scholar
  124. Stokholm J, Vogel A, Johannsen P, Waldemar G. Validation of the Danish Addenbrooke’s Cognitive Examination as a screening test in a memory clinic. Dement Geriatr Cogn Disord. 2009;27:361–5.PubMedCrossRefGoogle Scholar
  125. Stratford JA, LoGiudice D, Flicker L, Cook R, Waltrowicz W, Ames D. A memory clinic at a geriatric hospital: a report on 577 patients assessed with the CAMDEX over 9 years. Aust NZ J Psychiatry. 2003;37:319–26.CrossRefGoogle Scholar
  126. Tractenberg RE, Singer CM, Cummings JL, Thal LJ. The Sleep Disorders Inventory: an instrument for studies of sleep disturbance in persons with Alzheimer’s disease. J Sleep Res. 2003;12:331–7.PubMedPubMedCentralCrossRefGoogle Scholar
  127. Waldemar G, Dubois B, Emre M, et al. Recommendations for the diagnosis and management of Alzheimer’s disease and other disorders associated with dementia. Eur J Neurol. 2007;14:e1–26.PubMedCrossRefGoogle Scholar
  128. Wear HJ, Wedderburn CJ, Mioshi E, et al. The Cambridge Behavioural Inventory revised. Dement Neuropsychol. 2008;2:102–7.PubMedPubMedCentralCrossRefGoogle Scholar
  129. Wedderburn C, Wear H, Brown J, et al. The utility of the Cambridge Behavioural Inventory in neurodegenerative disease. J Neurol Neurosurg Psychiatry. 2008;79:500–3.PubMedCrossRefGoogle Scholar
  130. Yun CH, Lee HY, Lee SK, et al. Amyloid burden in obstructive sleep apnea. J Alzheimers Dis. 2017;59:21–9.PubMedCrossRefGoogle Scholar
  131. Zarit SH, Reever KE, Bach-Peterson J. Relatives of the impaired elderly: correlates of feelings of burden. Gerontologist. 1980;20:649–55.PubMedCrossRefGoogle Scholar
  132. Zarit SH, Orr NK, Zarit JM. The hidden victims of Alzheimer’s disease: families under stress. New York: New York University Press; 1985.Google Scholar
  133. Ziso B, Larner AJ. STOP-Bang: screening for obstructive sleep apnoea in a cognitive disorders clinic. J Sleep Disord Ther. 2016a;5:223.Google Scholar
  134. Ziso B, Larner A. REM sleep behaviour screening questionnaire (RBDSQ): validation study. Eur J Neurol. 2016b;23(Suppl1):240. (abstract P11273).Google Scholar
  135. Ziso B, Rawle M, Larner AJ. Accuracy of AD8 screening questionnaire for dementia. J Neurol Neurosurg Psychiatry. 2014;85:e4.CrossRefGoogle Scholar
  136. Ziso B, Stagg B, Rawle M, Larner A. AD8 informant screening questionnaire for cognitive impairment: pragmatic diagnostic test accuracy study. Eur J Neurol. 2015;22(Suppl1):339. (abstract P3131).Google Scholar

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Authors and Affiliations

  • A. J. Larner
    • 1
  1. 1.Cognitive Function ClinicWalton Centre for Neurology and NeurosurgeryLiverpoolUK

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