Differential Diagnosis

  • Manuela Franke-VögtlinEmail author
  • Stephan Vavricka


Although often clinical symptoms and first investigations arouse the suspicion of inflammatory bowel disease (IBD), clinical features, such as diarrhea, abdominal pain, or rectal bleeding, are not specific for either CD or UC. As no single diagnostic criterion proves IBD, and several other diseases can mimic CD or UC, accurate patient profiling, including patient history, endoscopy, lab investigations, ultrasound, and MRI is needed to make the final diagnosis.

Differential diagnosis varies with the type of symptoms, site of involvement, and the duration of symptoms and includes, e.g. irritable bowel syndrome, colon cancer, celiac disease, and infection disorders, but also rare diseases such as auto-immune enteropathy.


Crohn’s disease Ulcerative colitis Differential diagnosis 


  1. Dignass A, Van Assche G, Lindsay JO, Léman SJ, Colombel JF et al (2010) The second European evidence-based consensus on the diagnosis and management of Crohns disease: current management. J Crohns Colitis 4:28–62CrossRefGoogle Scholar
  2. Dignass A, Lindsay JO, Sturm A, Windsor A, Colombel JF, Allez M et al (2012) The second European evidence-based consensus on the diagnosis and management of ulcerative colitis part 2: current management. J Crohns Colitis 6:991–1030CrossRefGoogle Scholar
  3. Van Rheenen PF, van de Vijer E, Fidler V (2013) Fecal calprotectin for screening of patients with suspected inflammatory bowel disease: diagnostic metaanalysis. BMJ 341:c3369CrossRefGoogle Scholar
  4. Kumar NB, Nostrant TT, Appelman HD (1982) The histopathologic spectrum of acute self-limited colitis (acute infectious-type colitis). Am J Surg Pathol 6:523–529CrossRefGoogle Scholar
  5. Schumacher G, Sandstedt B, Molby R, Kollberg B (1991) Clinical and histologic features differentiating non-relapsing colitis from first attacks of inflammatory bowel disease. Scand J Gastroenterol 26:151–161CrossRefGoogle Scholar
  6. Sands B (2004) From symptom to diagnosis: clinical distinctions among various forms of intestinal inflammation. Gastroenterology 126:1518–1532CrossRefGoogle Scholar

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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Division of GastroenterologyTriemli HospitalZurichSwitzerland
  2. 2.Center for Gastroenterology und HepatologyZürichSwitzerland

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