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New Therapeutic Strategies

  • Klaartje Kok
  • Ana Ibarra
  • James LindsayEmail author
Chapter

Abstract

Despite major advances in the management of inflammatory bowel diseases (IBD) a considerable proportion of patients remain refractory to conventional and currently licenced biologic therapies. This chapter summarises the immunological pathways that drive intestinal inflammation in Crohn’s disease (CD) and ulcerative colitis (UC) and then reviews emerging drugs targeting different components of these pathways. These include biological agents against integrins and cytokines, small molecules; anti-sense oligonucleotides and cell based therapies.

Keywords

Leukocyte trafficking Antisense therapy Interleukin-12/23 JAK/STAT pathway SMAD7/TGF-β pathway Emerging treatments 

List of Abbreviations

CCR9

Chemokine receptor 9

CD

Crohn’s disease

DAI

Disease activity index

EMA

European Medicines Agency

FMT

Faecal microbiota transplantation

FDA

Food and Drug Administration

HSCT

Haematopoietic stem cell transplan-tation

IBD

Inflammatory bowel disease

IFN-γ

Interferon γ

IL

Interleukin

ICAM1

Intracellular adhesion molecule-1

JAK

Janus kinase

MSCs

Mesenchymal stem cells

Treg cells

Regulatory T cells

STAT

Signal transducer and activator of transcription

S1P

Sphingosine 1-phosphate

Th cells

T-helper cells

TDM

Therapeutic drug monitoring

TNF-α

Tumour necrosis factor-α

UC

Ulcerative colitis

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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  1. 1.Department of GastroenterologyBarts Health NHS TrustLondonUK
  2. 2.Centre for ImmunobiologyBlizard Institute, Barts and The London School of Medicine, Queen Mary University of LondonLondonUK

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