Electromagnetic Tomography for Brain Imaging and Stroke Diagnostics: Progress Towards Clinical Application

  • Abouzar Hamidipour
  • Tommy Henriksson
  • Markus Hopfer
  • Ramon Planas
  • Serguei Semenov
Chapter

Abstract

ElectroMagnetic Tomography (EMT) is an emerging biomedical imaging modality with great potential for non-invasive assessment of acute and chronic functional and pathological conditions of brain tissue. The mission of EMTensor GmbH is to bring this innovative technology into practical diagnostics of brain, including detection of stroke and traumatic brain injuries, followed by 24/7 monitoring of functional viability of tissue and an assessment of efficacy of treatment. The goal is to create a unique infrastructure based on compact-sized devices, information processing systems and services, which will lead to a breakthrough in brain diagnostics. The idea is to shift the paradigm from a reactive approach, where treatment follows a delayed diagnosis, to a proactive and preventive approach, where early diagnosis leads to successive treatment. The topics of this chapter include a brief introduction of the imaging procedures used at EMTensor GmbH. Furthermore, recent improvements of our image reconstruction algorithms will be discussed briefly, followed by a virtual study to explore the spectrum of potential applications of EMT technology for brain diagnostics. In a next step, the EMTensor BRain IMaging scanner Generation 1 (BRIM G1) will be described. In particular, attention will be given to the imaging results obtained with this scanner in clinical trials. Finally, recent improvements on imaging hardware and chamber topology will be discussed, which have been considered in our second generation brain imaging scanner (BRIM G2).

References

  1. 1.
    Scapaticci, R., Donato, L.D., Catapano, I., Crocco, L.: Prog. Electromagn. Res. B 40, 305 (2012).  https://doi.org/10.2528/PIERB12022006. http://www.jpier.org/pierb/pier.php?paper=12022006
  2. 2.
    Gabriel, S., Lau, R.W., Gabriel, C.: Phys. Med. Biol. 41(11), 2251 (1996). http://stacks.iop.org/0031-9155/41/i=11/a=002
  3. 3.
    Dielectric properties of body tissues at RF and microwave frequencies. http://www.fcc.gov/fcc-bin/dielec.sh
  4. 4.
    Schmid, G., Neubauer, G., Mazal, P.R.: Bioelectromagnetics 24(6), 423 (2003).  https://doi.org/10.1002/bem.10123. http://dx.doi.org/10.1002/bem.10123
  5. 5.
    Peyman, A., Holden, S.J., Watts, S., Perrott, R., Gabriel, C.: Phys. Med. Biol. 52(8), 2229 (2007). http://stacks.iop.org/0031-9155/52/i=8/a=013
  6. 6.
    Semenov, S., Hopfer, M., Planas, R., Hamidipour, A., Henriksson, T.: In: 2016 IEEE Conference on Antenna Measurements Applications (CAMA), pp. 1–4 (2016).  https://doi.org/10.1109/CAMA.2016.7815752
  7. 7.
    Devaney, A.J.: Inverse Problems in Scattering and Imaging, pp. 47–58. Adam Hilger, New York (1992). Chap. Current research topics in diffraction tomographyGoogle Scholar
  8. 8.
    Semenov, S.Y., Bulyshev, A.E., Souvorov, A.E., Svenson, R.H., Sizov, Y.E., Vorisov, V.Y., Posukh, V.G., Kozlov, I.M., Nazarov, A.G., Tatsis, G.P.: IEEE Trans. Microw. Theory Tech. 46(2), 133 (1998).  https://doi.org/10.1109/22.660979CrossRefGoogle Scholar
  9. 9.
    Bulyshev, A.E., Souvorov, A.E., Semenov, S.Y., Svenson, R.H., Nazarov, A.G., Sizov, Y.E., Tatsis, G.P.: Inverse Probl. 16(3), 863 (2000). http://stacks.iop.org/0266-5611/16/i=3/a=319
  10. 10.
    Bulyshev, A.E., Souvorov, A.E., Semenov, S.Y., Posukh, V.G., Sizov, Y.E.: Inverse Probl. 20(4), 1239 (2004). http://stacks.iop.org/0266-5611/20/i=4/a=013
  11. 11.
    Semenov, S.Y., Bulyshev, A.E., Abubakar, A., Posukh, V.G., Sizov, Y.E., Souvorov, A.E., van den Berg, P.M., Williams, T.C.: IEEE Trans. Microw. Theory Tech. 53(7), 2284 (2005).  https://doi.org/10.1109/TMTT.2005.850459CrossRefGoogle Scholar
  12. 12.
    Semenov, S.Y., Bulyshev, A.E., Posukh, V.G., Sizov, Y.E., Williams, T.C., Souvorov, A.E.: Ann. Biomed. Eng. 31(3), 262 (2003).  https://doi.org/10.1114/1.1553452CrossRefGoogle Scholar
  13. 13.
    Semenov, S.Y., Posukh, V.G., Bulyshev, A.E., Williams, T.C., Sizov, Y.E., Repin, P.N., Souvorov, A., Nazarov, A.: J. Electromagn. Waves Appl. 20(7), 873 (2006).  https://doi.org/10.1163/156939306776149897. http://dx.doi.org/10.1163/156939306776149897
  14. 14.
    Semenov, S., Kellam, J., Althausen, P., Williams, T., Abubakar, A., Bulyshev, A., Sizov, Y.: Phys. Med. Biol. 52(18), 5705 (2007). http://stacks.iop.org/0031-9155/52/i=18/a=015
  15. 15.
    Pozar, D.: Microwave Engineering. Wiley (2012). https://books.google.at/books?id=_YEbGAXCcAMC
  16. 16.
    Hiebel, M.: Fundamentals of Vector Network Analysis. Rohde & Schwarz (2007). https://books.google.at/books?id=jYG2PQAACAAJ
  17. 17.
    Tikhonov, A., Arsenin, V.: Solutions of ill-posed problems. Scripta Series in Mathematics. Winston (1977). https://books.google.at/books?id=ECrvAAAAMAAJ
  18. 18.
    Box, M., Swann, W.H., Davies, D.: Non-linear Optimization Techniques. Oliver and Boyd (1969)Google Scholar
  19. 19.
    Taflove, A., Hagness, S.: Computational Electrodynamics: the Finite-Difference Time-Domain Method (2000)Google Scholar
  20. 20.
    Concus, P., Golub, G.H.: SIAM J. Numer. Anal. 10(6), 1103 (1973). http://www.jstor.org/stable/2156207
  21. 21.
    Bloemenkamp, R.F., Abubakar, A., van den Berg, P.M.: Inverse Prob. 17(6), 1611 (2001). http://stacks.iop.org/0266-5611/17/i=6/a=305
  22. 22.
    Zhang, Z.Q., Liu, Q.H., Xiao, C., Ward, E., Ybarra, G., Joines, W.T.: IEEE Trans. Biomed. Eng. 50(10), 1180 (2003).  https://doi.org/10.1109/TBME.2003.817634CrossRefGoogle Scholar
  23. 23.
    Kao, H.P., Cardoso, E.R., Shwedyk, E.: IEEE Trans. Biomed. Eng. 46(9), 1121 (1999)CrossRefGoogle Scholar
  24. 24.
    Brainweb: Simulated Brain Database. http://brainweb.bic.mni.mcgill.ca/brainweb/
  25. 25.
    Andreuccetti, D., Fossi, R., Petrucci,C.: An internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 hz–100 ghz (1997). http://niremf.ifac.cnr.it/tissprop/
  26. 26.
    Semenov, S., Seiser, B., Stoegmann, E., Auff, E.: In: Conference on Antenna Measurements Applications (CAMA), 2014 IEEE, pp. 1–4 (2014).  https://doi.org/10.1109/CAMA.2014.7003417
  27. 27.
    Semenov, S., Planas, R., Hopfer, M., Hamidipour, A., Vasilenko, A., Stoegmann, E., Auff, E.: In: Biomedical Circuits and Systems Conference (BioCAS), 2015 IEEE, pp. 1–4 (2015).  https://doi.org/10.1109/BioCAS.2015.7348385
  28. 28.
    Souvorov, A.E., Bulyshev, A.E., Semenov, S.Y., Svenson, R.H., Nazarov, A.G., Sizov, Y.E., Tatsis, G.P.: IEEE Trans. Microw. Theory Tech. 46(11), 1654 (1998).  https://doi.org/10.1109/22.734548CrossRefGoogle Scholar
  29. 29.
    Hopfer, M., Planas, R., Hamidipour, A., Henriksson, T., Semenov, S.: IEEE Antennas Propag. Mag. 59(5), 86 (2017).  https://doi.org/10.1109/MAP.2017.2732225CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Abouzar Hamidipour
    • 1
  • Tommy Henriksson
    • 1
  • Markus Hopfer
    • 1
  • Ramon Planas
    • 1
  • Serguei Semenov
    • 1
  1. 1.EMTensor GmbHViennaAustria

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