Viral Manipulation of the Host Metabolic Network

  • Inês Mesquita
  • Jérôme Estaquier
Chapter
Part of the Experientia Supplementum book series (EXS, volume 109)

Abstract

Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successful infection. Viruses have evolved to retain a broad range of strategies to manipulate host cell metabolism and metabolic resources, channeling them toward the production of virion components leading to viral production. Although several viruses share similar strategies for manipulating host cell metabolism, these processes depend on several factors, namely, the viral life cycle and the metabolic and energetic status of the infected cell. Based on this knowledge, the development of new therapeutic approaches that circumvent viral spread through the target of altered metabolic pathways is an opportunity to tackle the infection. However, finding effective broad-spectrum strategies that aim at restoring to homeostasis the metabolic alterations induced upon virus infection is still a Holy Grail quest for antiviral therapies. Here, we review the strategies by which viruses manipulate host metabolism for their own benefit, with a particular emphasis on carbohydrate, glutamine, and lipid metabolism.

Keywords

Host cell metabolism Host–pathogen interaction Viral infection Metabolic manipulation 

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Inês Mesquita
    • 1
    • 2
  • Jérôme Estaquier
    • 3
    • 4
  1. 1.Life and Health Sciences Research Institute (ICVS), School of Medicine, University of MinhoBragaPortugal
  2. 2.ICVS/3B’s-PT Government Associate LaboratoryBraga, GuimarãesPortugal
  3. 3.Centre de Recherche du CHU de QuébecUniversité LavalQuébecCanada
  4. 4.CNRS FR 3636, Université Paris DescartesParisFrance

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