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A Painful Subcutaneous Nodule

  • Rebecca S. Thornhill
  • Nicole Asher
Chapter

Abstract

A 68-year-old man with a remote history of squamous cell carcinoma (SCC) involving the submental area presented with a slowly growing painful 2-cm subcutaneous nodule. Low-power examination (Fig. 22.1) yielded an ill-circumscribed deep dermal/subcutaneous lesion. At intermediate power (Fig. 22.2), a dense scar is seen approximating spindled cellular areas that at high-power examination (Fig. 22.3) yielded a wavy orientation typical of nerve tissue. The nerves are infiltrated and surrounded by densely chromatic cohesive cells, and in some areas dyskeratosis can be seen. Discernible inflammation is not identified.

Keywords

Perineural tumoral infiltrates Squamous cell carcinoma Peritumoral fibrosis 

References

  1. 1.
    Dunn M, Morgan MB, Beer TW, Chen KT, Acker SM. Histologic mimics of perineural invasion. J Cutan Pathol. 2008;36:937–42.CrossRefPubMedCentralPubMedGoogle Scholar
  2. 2.
    Hassanein A, Proper S, Depcik-Smith ND, Flowers FP. Peritumoral fibrosis in basal cell carcinoma and squamous cell carcinoma mimicking perineural invasion. Dermatol Surg. 2005;31:1101–6.CrossRefPubMedCentralPubMedGoogle Scholar
  3. 3.
    Husain E, Al-Daraji W. Epithelial sheath neuroma: be aware of benign perineural invasion! J Cutan Pathol. 2009;36:570–2.CrossRefPubMedCentralPubMedGoogle Scholar
  4. 4.
    Cheng L, O’Brien G. Re-excision perineural invasion in basal cell carcinoma. Pathology. 2013;45:433–5.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2018

Authors and Affiliations

  1. 1.Greenville Health SystemUniversity of South CarolinaGreenvilleUSA
  2. 2.American University of the Caribbean School of MedicineClermontUSA

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