Hematologic Malignancies Affecting the Temporal Bone

  • Paul W. GidleyEmail author
  • Nathan Fowler
  • Marc-Elie Nader


Hematologic diseases can involve the temporal bone. Lymphoma, leukemia, and myeloma have otologic manifestations. While lymphoma typically presents as nodal disease at regional nodal stations, extranodal manifestations have been described in the outer, middle, and inner ear. Treatment of localized and systemic lymphoma typically employs chemotherapy with or without radiotherapy. Leukemic infiltration of the temporal bone can also occur, with acute myelogenous leukemia being the most common subtype observed. Leukemic infiltration of the temporal bone involves primarily the petrous apex, and it can extend to involve the inner ear, middle ear, and facial nerve. Plasmacytoma and multiple myeloma can also present with ear and temporal bone involvement and require tissue biopsy for definitive diagnosis. Although rare, hematologic malignancies of the ear and temporal bone can be devastating. Careful attention to associated symptoms and laboratory abnormalities can alert the treating physician to the possibility of an occult leukemia, lymphoma, or myeloma.


Hodgkin’s disease Lymphoma Non-Hodgkin’s lymphoma Leukemia Acute leukemia Chronic leukemia Myeloid sarcoma Mycosis fungoides Plasmacytoma Temporal bone Middle ear External ear 



Adriamycin, bleomycin, vinblastine, and dacarbazine


Acute lymphocytic leukemia


Acute myeloid leukemia


Acute promyelocytic leukemia


All-trans retinoic acid


Chronic lymphocytic leukemia


Chronic myeloid leukemia


Central nervous system


Cerebrospinal fluid


Computerized tomography


Diffuse large B-cell lymphoma


External auditory canal


Extramedullary plasmacytoma


Human immunodeficiency virus


Hodgkin’s lymphoma


Cyclophosphamide, mesna, doxorubicin, vincristine, dexamethasone


Internal auditory canal




Lactate dehydrogenase


Myeloproliferative disorder


Myelodysplastic syndrome


Multiple myeloma


Magnetic resonance imaging


Myeloid sarcoma


Non-Hodgkin’s lymphoma


Positron emission tomography/computerized tomography


Primary lymphoma of bone


Solitary plasmacytoma of bone


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Paul W. Gidley
    • 1
    Email author
  • Nathan Fowler
    • 1
  • Marc-Elie Nader
    • 1
  1. 1.Department of Head and Neck SurgeryThe University of Texas M.D. Anderson Cancer CenterHoustonUSA

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