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Human Aging and Cancer: Role of miRNA in Tumor Microenvironment

  • Oleta A. Sandiford
  • Caitlyn A. Moore
  • Jun Du
  • Mathieu Boulad
  • Marina Gergues
  • Hussam Eltouky
  • Pranela Rameshwar
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1056)

Abstract

Human aging is an inevitable and complex phenomenon characterized by a progressive, gradual degradation of physiological and cellular processes that leads from vulnerability to death. Mammalian somatic cells display limited proliferative properties in vitro that results in a process of permanent cell cycle arrest commonly known as senescence. Events leading to cellular senescence are complex but may be due to the increase in tumor suppressor genes, caused by lifetime somatic mutations. Cumulative mutation leaves an imprint on the genome of the cell, an important risk factor for the occurrence of cancer. Adults over the age of 65+ are vulnerable to age related diseases such as cancers but such changes may begin at middle age. MicroRNAs (miRNAs), which are small non-coding RNA, can regulate cancer progression, recurrence and metastasis. This chapter discusses the role of miRNA in tumor microenvironment, consequent to aging.

Keywords

miRNA Breast cancer Aging Hematopoiesis Microenvironment Bone marrow 

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© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Oleta A. Sandiford
    • 1
  • Caitlyn A. Moore
    • 1
  • Jun Du
    • 1
  • Mathieu Boulad
    • 1
  • Marina Gergues
    • 1
  • Hussam Eltouky
    • 1
  • Pranela Rameshwar
    • 1
  1. 1.Division of Hematology/Oncology, Department of MedicineNew Jersey Medical School, Rutgers School of Biomedical Health ScienceNewarkUSA

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