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The Role of ABC Transporters in Drug-Resistant Leishmania

  • Adriano C. Coelho
  • Paulo C. Cotrim
Chapter

Abstract

The ATP-binding cassette (ABC) transporters belong to the largest family of transmembrane proteins found in living organisms. These proteins are present in prokaryotes and eukaryotes and are mainly involved in the transport of a variety of molecules across cellular membranes, whereas others are involved in biological processes unrelated to transport. The genome sequencing of several Leishmania species confirmed the presence of members for all eight different subfamilies of ABC transporters (ABCA to ABCH), according to their specific functional and molecular characteristics. These proteins have recently been characterized in Leishmania; some of them associated with drug resistance, which is a significant field in leishmaniasis chemotherapy, a disease still lacking effective treatment, with increasing daily reports of therapeutic failure. In this chapter, we focus our discussion on the association of these proteins with drug resistance in leishmaniasis and its fundamental role in the pathology and pharmacology of this medically important protozoan parasite that currently infects around 12 million people in the world.

Notes

Acknowledgments

We thank Glaucia Paranhos for critical reading of the chapter.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Departamento de Biologia AnimalInstituto de Biologia, Universidade Estadual de CampinasCampinasBrazil
  2. 2.Departamento de Moléstias Infecciosas e ParasitáriasInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São PauloSão PauloBrazil

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