Fiber-Flux Diffusion Density for White Matter Tracts Analysis: Application to Mild Anomalies Localization in Contact Sports Players

  • Itay Benou
  • Ronel Veksler
  • Alon Friedman
  • Tammy Riklin Raviv
Conference paper
Part of the Mathematics and Visualization book series (MATHVISUAL)

Abstract

We present the concept of fiber-flux density for locally quantifying white matter (WM) fiber bundles. By combining scalar diffusivity measures (e.g., fractional anisotropy) with fiber-flux measurements, we define new local descriptors called Fiber-Flux Diffusion Density (FFDD) vectors. Applying each descriptor throughout fiber bundles allows along-tract coupling of a specific diffusion measure with geometrical properties, such as fiber orientation and coherence. A key step in the proposed framework is the construction of an FFDD dissimilarity measure for sub-voxel alignment of fiber bundles, based on the fast marching method (FMM). The obtained aligned WM tract-profiles enable meaningful inter-subject comparisons and group-wise statistical analysis. We demonstrate our method using two different datasets of contact sports players . Along-tract pairwise comparison as well as group-wise analysis, with respect to non-player healthy controls, reveal significant and spatially-consistent FFDD anomalies. Comparing our method with along-tract FA analysis shows improved sensitivity to subtle structural anomalies in football players over standard FA measurements.

Notes

Acknowledgements

This research is partially supported by the Israel Science Foundation (T.R.R. 1638/16) and the IDF Medical Corps (T.R.R.).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Itay Benou
    • 1
    • 2
  • Ronel Veksler
    • 2
    • 3
  • Alon Friedman
    • 2
    • 3
    • 4
  • Tammy Riklin Raviv
    • 1
    • 2
  1. 1.Department of Electrical EngineeringBen-Gurion University of the NegevBeer-ShevaIsrael
  2. 2.The Zlotowski Center for NeuroscienceBen-Gurion University of the NegevBeer-ShevaIsrael
  3. 3.Department of Physiology and Cell BiologyBen-Gurion University of the NegevBeer-ShevaIsrael
  4. 4.Faculty of Medicine, Department of Medical Neuroscience and Brain Repair CentreDalhousie UniversityHalifaxCanada

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