Advertisement

Incidence of Moyamoya Disease in Denmark: A Population-Based Register Study

  • Peter Birkeland
  • Jens Lauritsen
Conference paper
Part of the Acta Neurochirurgica Supplement book series (NEUROCHIRURGICA, volume 129)

Abstract

In this first population-based study of moyamoya disease (MMD) in Europe, the authors identified 56 patients with MMD in Denmark during the period 1994–2015 using nationwide registers. The overall incidence was 0.047 per 100,000 person-years, which is about one-tenth that reported in Japan. Otherwise the epidemiological features were comparable: there was a bimodal age distribution with peaks in the age groups 0–9 years and 30–39 years, with twice as many females as males.

Keywords

Moyamoya disease Epidemiology Stroke Cerebrovascular 1994–2015 Scandinavian 

Notes

Ethics and Conflict of Interest

Ethical Approval

For this type of study formal consent is not required.

Conflict of Interest

The authors declare that they have no conflict of interest.

Funding

This study was supported by a grant from Ingeniør K.A. Rohde of Hustrus Legat.

References

  1. 1.
    Scott RM, Smith ER. Moyamoya disease and moyamoya syndrome. N Engl J Med. 2009;360:1226–37.CrossRefGoogle Scholar
  2. 2.
    Birkeland P, Gardner K, Kesse-Adu R, Davies J, Lauritsen J, Rom Poulsen F, Tolias CM, Thein SL. Intracranial aneurysms in sickle-cell disease are associated with the hemoglobin SS genotype but not with moyamoya syndrome. Stroke. 2016;47:1710–3.CrossRefGoogle Scholar
  3. 3.
    Hansen RN, Andersen G, Longin E. Moyamoya. Ugeskr Laeger. 2011;173:281–2.PubMedGoogle Scholar
  4. 4.
    Kondziella D. Diagnosis and treatment of rare causes of ischaemic stroke. Ugeskr Laeger. 2016;178:V02160101.PubMedGoogle Scholar
  5. 5.
    Baba T, Houkin K, Kuroda S. Novel epidemiological features of moyamoya disease. J Neurol Neurosurg Psychiatry. 2008;79:900–4.CrossRefGoogle Scholar
  6. 6.
    Hoshino H, Izawa Y, Suzuki N. Epidemiological features of moyamoya disease in Japan. Neurol Med Chir (Tokyo). 2012;52:295–8.CrossRefGoogle Scholar
  7. 7.
    Wakai K, Tamakoshi A, Ikezaki K, Fukui M, Kawamura T, Aoki R, Kojima M, Lin Y, Ohno Y. Epidemiological features of moyamoya disease in Japan: findings from a nationwide survey. Clin Neurol Neurosurg. 1997;99(Suppl 2):S1–5.CrossRefGoogle Scholar
  8. 8.
    Acker G, Goerdes S, Schneider UC, Schmiedek P, Czabanka M, Vajkoczy P. Distinct clinical and radiographic characteristics of moyamoya disease amongst European Caucasians. Eur J Neurol. 2015;22:1012–7.CrossRefGoogle Scholar
  9. 9.
    Hever P, Alamri A, Tolias C. Moyamoya angiopathy—is there a Western phenotype? Br J Neurosurg. 2015;29:765–71.CrossRefGoogle Scholar
  10. 10.
    Kleinloog R, Regli L, Rinkel GJ, Klijn CJ. Regional differences in incidence and patient characteristics of moyamoya disease: a systematic review. J Neurol Neurosurg Psychiatry. 2012;83:531–6.CrossRefGoogle Scholar
  11. 11.
    Lynge E, Sandegaard JL, Rebolj M. The Danish national patient register. Scand J Public Health. 2011;39:30–3.CrossRefGoogle Scholar
  12. 12.
    Uchino K, Johnston SC, Becker KJ, Tirschwell DL. Moyamoya disease in Washington State and California. Neurology. 2005;65:956–8.CrossRefGoogle Scholar
  13. 13.
    Kossorotoff M, Herve D, Toulgoat F, Renaud C, Presles E, Chabriat H, Chabrier S. Paediatric moyamoya in mainland France: a comprehensive survey of academic neuropaediatric centres. Cerebrovasc Dis. 2012;33:76–9.CrossRefGoogle Scholar
  14. 14.
    Research Committee on the Pathology and Treatment of Spontaneous. Occlusion of the Circle of Willis, Health Labour Sciences Research Grant for Research on Measure for Infractable Diseases. Guidelines for diagnosis and treatment of moyamoya disease (spontaneous occlusion of the circle of Willis). Neurol Med Chir (Tokyo). 2012;52:245–66.CrossRefGoogle Scholar
  15. 15.
    Wermuth L, Lassen CF, Himmerslev L, Olsen J, Ritz B. Validation of hospital register-based diagnosis of Parkinson’s disease. Dan Med J. 2012;59:A4391.PubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of NeurosurgeryAalborg University HospitalAalborgDenmark
  2. 2.Department of Orthopaedic SurgeryOdense University HospitalOdenseDenmark
  3. 3.Institute of Clinical ResearchUniversity of Southern DenmarkOdenseDenmark

Personalised recommendations