Heparin-Induced Thrombocytopenia

  • Emily Downs
  • Svetlana Goldman
  • Surabhi Palkimas
  • Aditya M. Sharma
Chapter

Abstract

Heparin-induced thrombocytopenia (HIT) is an uncommon condition with grave consequences. It is a clinicopathological diagnosis which can often be complex. However, delayed diagnosis and inadequate or inappropriate treatment can lead to life- and limb-threatening outcomes. This chapter will describe the syndrome of HIT (and HITT—heparin-induced thrombocytopenia with thrombosis) as it is now known, including its history, pathophysiology, diagnostic process with the current testing paradigm, and updated treatment options for HIT.

Keywords

Heparin Thrombocytopenia Heparin-induced thrombocytopenia Thrombosis 

Abbreviations

ACCP

American College of Chest Physicians

ACT

Activated clotting time

CFX

Chromogenic factor X

CPB

Cardiopulmonary bypass

DOAC

Direct oral anticoagulants

DTI

Direct thrombin inhibitor

DVT

Deep vein thrombosis

ELISA

Enzyme-linked immunosorbent assay

HAT

Heparin-associated thrombocytopenia

HEP

HIT Expert Probability

HIT

Heparin-induced thrombocytopenia

INR

International normalized ratio

IVC

Inferior vena cava

LMWH

Low-molecular-weight heparin

O.D.

Optical density

PaGIA

Particle gel immunoassay

PCI

Percutaneous coronary intervention

PE

Pulmonary embolism

PF4

Platelet factor 4

SRA

Serotonin release assay

VKA

Vitamin K antagonist

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Emily Downs
    • 1
  • Svetlana Goldman
    • 2
  • Surabhi Palkimas
    • 2
  • Aditya M. Sharma
    • 3
  1. 1.Department of Surgery, Division of Thoracic and Cardiovascular SurgeryUniversity of Virginia Medical Center, University of VirginiaCharlottesvilleUSA
  2. 2.Department of PharmacyUniversity of Virginia Medical Center, University of VirginiaCharlottesvilleUSA
  3. 3.Department of Medicine, Cardiovascular Medicine Division, Heart and Vascular CenterUniversity of Virginia Medical Center, University of VirginiaCharlottesvilleUSA

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