A Systematic Review of the High-flow Nasal Cannula for Adult Patients

Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM)


  1. 1.
    Ozyilmaz E, Ugurlu AO, Nava S (2014) Timing of noninvasive ventilation failure: causes, risk factors, and potential remedies. BMC Pulm Med 14:19CrossRefGoogle Scholar
  2. 2.
    Shoemaker M, Pierce M, Yoder B, DiGeronimo R (2007) High flow nasal cannula versus nasal CPAP for neonatal respiratory disease: a retrospective study. J Perinatol 27:85–91CrossRefGoogle Scholar
  3. 3.
    Ward JJ (2013) High-flow oxygen administration by nasal cannula for adult and perinatal patients. Respir Care 58:98–122CrossRefGoogle Scholar
  4. 4.
    Nishimura M (2016) High-flow nasal cannula oxygen therapy in adults. J Intensive Care 3:15CrossRefGoogle Scholar
  5. 5.
    Parke RL, Eccleston ML, McGuinness SP (2011) The effects of flow on airway pressure during nasal high-flow oxygen therapy. Respir Care 56:1151–1155CrossRefGoogle Scholar
  6. 6.
    Groves N, Tobin A (2007) High flow nasal oxygen generates positive airway pressure in adult volunteers. Aust Crit Care 20:126–131CrossRefGoogle Scholar
  7. 7.
    Frizzola M, Miller TL, Rodriguez ME et al (2011) High-flow nasal cannula: Impact on oxygenation and ventilation in an acute lung injury model. Pediatr Pulmonol 46:67–74CrossRefGoogle Scholar
  8. 8.
    Hasani A, Chapman T, McCool D et al (2008) Domiciliary humidification improves lung mucociliary clearance in patients with bronchiectasis. Chron Respir Dis 5:81–86CrossRefGoogle Scholar
  9. 9.
    Sztrymf B, Messika J, Bertrand F et al (2011) Beneficial effects of humidified high flow nasal oxygen in critical care patients: a prospective pilot study. Intensive Care Med 37:1780–1786CrossRefGoogle Scholar
  10. 10.
    Itagaki T, Okuda N, Tsunano Y et al (2014) Effect of high-flow nasal cannula on thoraco-abdominal synchrony in adult critically ill patients. Respir Care 59:70–74CrossRefGoogle Scholar
  11. 11.
    Corley A, Caruana LR, Barnett AG et al (2011) Oxygen delivery through high-flow nasal cannulae increase end-expiratory lung volume and reduce respiratory rate in post-cardiac surgical patients. Br J Anaesth 107:998–1004CrossRefGoogle Scholar
  12. 12.
    Esteban A, Frutos-Vivar F, Ferguson ND et al (2004) Noninvasive positive-pressure ventilation for respiratory failure after extubation. N Engl J Med 350:2452–2460CrossRefGoogle Scholar
  13. 13.
    Kang BJ, Koh Y, Lim C-M et al (2015) Failure of high-flow nasal cannula therapy may delay intubation and increase mortality. Intensive Care Med 41:623–632CrossRefGoogle Scholar
  14. 14.
    Rello J, Pérez M, Roca O et al (2012) High-flow nasal therapy in adults with severe acute respiratory infection. J Crit Care 27:434–439CrossRefGoogle Scholar
  15. 15.
    Frat JP, Thille AW, Mercat A et al (2015) High-flow oxygen through nasal cannula in acute hypoxemic respiratory failure. N Engl J Med 372:2185–2196CrossRefGoogle Scholar
  16. 16.
    Belley-Côté EP, Duceppe E, Whitlock RP (2015) High-flow nasal cannula oxygen in respiratory failure. N Engl J Med 373:1373CrossRefGoogle Scholar
  17. 17.
    Wawrzeniak IC, Moraes RB, Fendt LCC (2015) High-flow nasal cannula oxygen in respiratory failure. N Engl J Med 373:1373CrossRefGoogle Scholar
  18. 18.
    Sehgal IS, Dhooria S, Agarwal R (2015) High-flow nasal cannula oxygen in respiratory failure. N Engl J Med 373:1374PubMedGoogle Scholar
  19. 19.
    Frat JP, Ragot S, Thille AW (2015) High-flow nasal cannula oxygen in respiratory failure. N Engl J Med 373:1373–1375CrossRefGoogle Scholar
  20. 20.
    Ou X, Hua Y, Liu J et al (2017) Effect of high-flow nasal cannula oxygen therapy in adults with acute hypoxemic respiratory failure: a meta-analysis of randomized controlled trials. CMAJ 189:E260–E267CrossRefGoogle Scholar
  21. 21.
    Monro-Somerville T, Sim M, Ruddy J et al (2017) The effect of high-flow nasal cannula oxygen therapy on mortality and intubation rate in acute respiratory failure. Crit Care Med 45:e449–e456CrossRefGoogle Scholar
  22. 22.
    Roca O, Pérez-Terán P, Masclans JR et al (2013) Patients with New York Heart Association class III heart failure may benefit with high flow nasal cannula supportive therapy: high flow nasal cannula in heart failure. J Crit Care 28:741–746CrossRefGoogle Scholar
  23. 23.
    Esquinas AM, Papadakos PJ (2014) High-flow nasal cannula supportive therapy in chronic heart failure: a partial or completed “CPAP-like effect”? J Crit Care 29:465CrossRefGoogle Scholar
  24. 24.
    Krinsley JS, Reddy PK, Iqbal A (2012) What is the optimal rate of failed extubation? Crit Care 16:111CrossRefGoogle Scholar
  25. 25.
    Kulkarni AP, Agarwal V (2008) Extubation failure in intensive care unit: predictors and management. Indian J Crit Care Med 12:1–9CrossRefGoogle Scholar
  26. 26.
    Stéphan F, Barrucand B, Petit P et al (2015) High-flow nasal oxygen vs noninvasive positive airway pressure in hypoxemic patients after cardiothoracic surgery. JAMA 313:2331CrossRefGoogle Scholar
  27. 27.
    Parke R, McGuinness S, Dixon R, Jull A (2013) Open-label, phase II study of routine high-flow nasal oxygen therapy in cardiac surgical patients. Br J Anaesth 111:925–931CrossRefGoogle Scholar
  28. 28.
    Corley A, Bull T, Spooner AJ et al (2015) Direct extubation onto high-flow nasal cannulae post-cardiac surgery versus standard treatment in patients with a BMI≥30: a randomised controlled trial. Intensive Care Med 41:887–894CrossRefGoogle Scholar
  29. 29.
    Zhu Y, Yin H, Zhang R, Wei J (2017) High-flow nasal cannula oxygen therapy vs conventional oxygen therapy in cardiac surgical patients: a meta-analysis. J Crit Care 38:123–128CrossRefGoogle Scholar
  30. 30.
    Futier E, Paugam-Burtz C, Godet T et al (2016) Effect of early postextubation high-flow nasal cannula vs conventional oxygen therapy on hypoxaemia in patients after major abdominal surgery: a French multicentre randomised controlled trial (OPERA). Intensive Care Med 42:1888–1898CrossRefGoogle Scholar
  31. 31.
    Maggiore SM, Idone FA, Vaschetto R et al (2014) Nasal high-flow versus venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med 190:282–288CrossRefGoogle Scholar
  32. 32.
    Hernández G, Vaquero C, Colinas L et al (2016) Effect of postextubation high-flow nasal cannula vs noninvasive ventilation on reintubation and postextubation respiratory failure in high-risk patients. JAMA 316:1565CrossRefGoogle Scholar
  33. 33.
    Hernández G, Vaquero C, González P et al (2016) Effect of postextubation high-flow nasal cannula vs conventional oxygen therapy on reintubation in low-risk patients. JAMA 315:1354CrossRefGoogle Scholar
  34. 34.
    Simon M, Braune S, Frings D et al (2014) High-flow nasal cannula oxygen versus non-invasive ventilation in patients with acute hypoxaemic respiratory failure undergoing flexible bronchoscopy - a prospective randomised trial. Crit Care 18:712CrossRefGoogle Scholar
  35. 35.
    Lucangelo U, Vassallo FG, Marras E et al (2012) High-flow nasal interface improves oxygenation in patients undergoing bronchoscopy. Crit Care Res Pract 2012:506382PubMedPubMedCentralGoogle Scholar
  36. 36.
    Neilipovitz DT, Crosby ET (2007) No evidence for decreased incidence of aspiration after rapid sequence induction. Can J Anesth 54:748–764CrossRefGoogle Scholar
  37. 37.
    Vourc’h M, Asfar P, Volteau C et al (2015) High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med 41:1538–1548CrossRefGoogle Scholar
  38. 38.
    Jaber S, Monnin M, Girard M et al (2016) Apnoeic oxygenation via high-flow nasal cannula oxygen combined with non-invasive ventilation preoxygenation for intubation in hypoxaemic patients in the intensive care unit: the single-centre, blinded, randomised controlled OPTINIV trial. Intensive Care Med 42:1877–1887CrossRefGoogle Scholar
  39. 39.
    Simon M, Wachs C, Braune S et al (2016) High-flow nasal cannula versus bag-valve-mask for preoxygenation before intubation in subjects with hypoxemic respiratory failure. Respir Care 61:1160–1167CrossRefGoogle Scholar
  40. 40.
    Heinrich S, Horbach T, Stubner B et al (2014) Benefits of heated and humidified high flow nasal oxygen for preoxygenation in morbidly obese patients undergoing bariatric surgery: a randomized controlled study. J Obes Bariatrics 1:1–7Google Scholar
  41. 41.
    Azoulay E, Lemiale V, Mokart D et al (2014) Acute respiratory distress syndrome in patients with malignancies. Intensive Care Med 40:1106–1114CrossRefGoogle Scholar
  42. 42.
    Ewig S, Torres A, Riquelme R et al (1998) Pulmonary complications in patients with haematological malignancies treated at a respiratory ICU. Eur Respir J 12:116–122CrossRefGoogle Scholar
  43. 43.
    Coudroy R, Jamet A, Petua P et al (2016) High-flow nasal cannula oxygen therapy versus noninvasive ventilation in immunocompromised patients with acute respiratory failure: an observational cohort study. Ann Intensive Care 6:45CrossRefGoogle Scholar
  44. 44.
    Lee HY, Rhee CK, Lee JW (2015) Feasibility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematologic malignancies: a retrospective single-center study. J Crit Care 30:773–777CrossRefGoogle Scholar
  45. 45.
    Harada K, Kurosawa S, Hino Y et al (2016) Clinical utility of high-flow nasal cannula oxygen therapy for acute respiratory failure in patients with hematological disease. Springerplus 5:512CrossRefGoogle Scholar
  46. 46.
    Booth S, Anderson H, Swannick M et al (2004) The use of oxygen in the palliation of breathlessness. A report of the expert working group of the scientific committee of the association of palliative medicine. Respir Med 98:66–77CrossRefGoogle Scholar
  47. 47.
    Epstein AS, Hartridge-Lambert SK, Ramaker JS et al (2011) Humidified high-flow nasal oxygen utilization in patients with cancer at Memorial Sloan-Kettering Cancer Center. J Palliat Med 14:835–839CrossRefGoogle Scholar
  48. 48.
    Peters SG, Holets SR, Gay PC (2013) High-flow nasal cannula therapy in do-not-intubate patients with hypoxemic respiratory distress. Respir Care 58:597–600PubMedGoogle Scholar
  49. 49.
    Fealy N, Osborne C, Eastwood GM et al (2016) Nasal high-flow oxygen therapy in ICU: a before-and-after study. Aust Crit Care 29:17–22CrossRefGoogle Scholar
  50. 50.
    Rabbat A, Blanc K, Lefebvre A, Lorut C (2016) Nasal high flow oxygen therapy after extubation: the road is open but don’t drive too fast! J Thorac Dis 8:E1620–E1624CrossRefGoogle Scholar
  51. 51.
    Ni YN, Luo J, Yu H et al (2017) Can high-flow nasal cannula reduce the rate of endotracheal intubation in adult patients with acute respiratory failure compared with conventional oxygen therapy and noninvasive positive pressure ventilation?: a systematic review and meta-analysis. Chest 151:764–775CrossRefGoogle Scholar

Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  1. 1.The Intensive Care Unit of the Shaare Zedek Medical CentreJerusalemIsrael
  2. 2.The Faculty of Medicine of the Hebrew UniversityJerusalemIsrael

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