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Heat Shock Proteins in Leptospirosis

  • Arada Vinaiphat
  • Visith ThongboonkerdEmail author
Chapter
Part of the Heat Shock Proteins book series (HESP, volume 12)

Abstract

Leptospirosis caused by pathogenic Leptospira spirochetes remains an important zoonotic disease worldwide. Like many other dimorphic bacterial pathogens, leptospires have abilities to adapt themselves to survive in a wide range of environmental conditions outside and inside the infected hosts. Recent investigations using genomics and proteomics approaches have revealed that several heat shock proteins (HSP) encoded by the conserved immunodominant antigenic region of Hsp genes among the pathogenic leptospires are associated with their adaption to survive, infectivity and virulence. Understanding how HSP are differentially expressed and regulated during leptospiral infection is thus crucial to develop better serodiagnostic test and vaccine for clinical use. This chapter summarizes the current knowledge of HSP expression and their roles in leptospirosis and also extensively discusses future perspectives of this arena to battle leptospirosis with the ultimate goals for better therapeutic outcome and successful prevention.

Keywords

Chaperone HSP Immunoproteomics Leptospira Leptospirosis OMPs Proteomics Virulence 

Abbreviations

APC

Antigen presenting cells

HSP

Heat shock proteins

LPS

Lipopolysaccharide

MAT

Microscopic agglutination test

MHC

Major histocompatibility complex

MS

Mass spectrometry

OMPs

Outer-membrane proteins

sHSP

Small heat shock proteins

Notes

Acknowledgements

This work was supported by Mahidol University research grant and the Thailand Research Fund (IRN60W0004 and IRG5980006).

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2017

Authors and Affiliations

  1. 1.Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj HospitalMahidol UniversityBangkokThailand

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