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Pustular Psoriasis

  • Andrew Johnston
Chapter

Abstract

Pustular forms of psoriasis are a group of rare, debilitating, and often life-threatening inflammatory skin diseases characterized by episodic skin infiltration of neutrophils, pustule development, erythema and desquamation, which can manifest in the presence or absence of chronic plaque psoriasis. The skin involvement is frequently accompanied by a high-grade fever, fatigue and systemic inflammation. Despite having different genetic and environmental etiologies generalized pustular psoriasis (GPP), acute generalized exanthemous pustulosis (AGEP), palmo-plantar pustulosis (PPP) and acrodermatitis continua of Hallopeau (ACH) are all characterized by a massive influx of neutrophils into the epidermis, thus share some mechanistic aspects. To date, treatments for these diseases have been unsatisfactory with disease recurrence common; however, recent genetic data and ongoing clinical trials with biologic therapies are revealing hitherto unknown mechanisms, substantially improving our understanding and management of these diseases.

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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of MichiganAnn ArborUSA

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