The Role of TSH Suppression in the Management of Differentiated Thyroid Cancer

  • Rami Alrezk
  • Joanna Klubo-GwiezdzinskaEmail author


TSH suppression is a therapeutic modality with a pivotal role in the long-term management of intermediate- and high-risk patients with differentiated thyroid cancer. However, therapy with suppressive doses of levothyroxine is associated with increased cardiovascular risk, especially in older patients, and negatively affects bone health, particularly in postmenopausal women. Therefore, this chapter describes the risks and benefits of TSH suppression in thyroid cancer and, as such, forms a basis for the individualized patient-tailored approach to the therapy with levothyroxine. This review summarizes different guidelines implemented in the United States, Europe, Latin America, and Japan focused on the role of long-term TSH suppression and its association with mortality and recurrence rate among thyroid cancer patients.


TSH Suppression Side effects Thyroid cancer 


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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  1. 1.National Institutes of Health—National Institute of Diabetes and Digestive and Kidney DiseaseBethesdaUSA

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