Imaging of Differentiated Thyroid Cancer with Iodine-124 and F-18-FDG

  • James NagarajahEmail author
  • Walter Jentzen
  • Vanessa Stebner
  • Ina Binse
  • Marcel Janssen
  • Ravinder K. Grewal


Positron emission tomography (PET) is an established imaging device in oncological clinical setting using several isotope-labeled compounds of which I-124 and F-18-labeled fluorodeoxyglucose (FDG) are the most relevant ones for imaging of patients with differentiated thyroid cancer (DTC). Whereas I-124 PET is applied to identify thyroid cancer cells expressing the sodium-iodine symporter (NIS) which is correlated to a well-differentiated phenotype, F-18-FDG PET reveals thyroid cancer cells with a higher level of dedifferentiated feature with a more aggressive phenotype. Besides imaging NIS, I-124 PET enables a dosimetry approach to calculate radiation doses delivered to target lesions. In this chapter, we discuss the role of these two imaging techniques in thyroid cancer patients.


DTC I-124 PET/CT F-18 FDG PET/CT I-124 PET/MRI Dosimetry 


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© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • James Nagarajah
    • 1
    • 2
    Email author
  • Walter Jentzen
    • 2
  • Vanessa Stebner
    • 2
  • Ina Binse
    • 2
  • Marcel Janssen
    • 1
  • Ravinder K. Grewal
    • 3
  1. 1.Department of Radiology and Nuclear MedicineRadboudumcNijmegenThe Netherlands
  2. 2.Klinik für NuklearmedizinUniversitätsklinikum Essen, Universität Duisburg-EssenEssenGermany
  3. 3.Molecular Imaging and Therapy ServiceMemorial Sloan Kettering Cancer Center, Weill Cornell Medical CollegeNew YorkUSA

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