The Inhibition of Prostaglandin Formation

  • Roger P. Smith


The primary therapeutic modality for patients with primary dysmenorrhea and heavy menstrual bleeding is the nonsteroidal anti-inflammatory drugs (NSAIDs). These agents act primarily to block the formation of the prostaglandins responsible for the symptoms. As noted in the previous chapter, the two prostaglandins responsible, PGE2 and PGF, are both made from arachidonic acid through the enzymatic action of cyclooxygenases. Found in two main isoforms, COX-1 and COX-2, the characteristics of these two enzymes allow for specific and effective inhibition of their function. Understanding how this occurs, and the differences between agents that inhibit these enzymes, allows the clinician to better understand and choose effective therapy.


Cyclooxygenase isoforms Inhibition Non-steroidal anti-inflammatory drug Selective inhibition Carboxylates Enolic acid Active binding site Propionic acid Anthranilic acid Salicylate 


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Copyright information

© Springer International Publishing AG 2018

Authors and Affiliations

  • Roger P. Smith
    • 1
  1. 1.Florida Atlantic UniversityBoca RatonUSA

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