Neurobiology of Schizophrenia: Electrophysiological Indices

  • Martha Koukkou
  • Thomas Koenig
  • Anja Bänninger
  • Kathryn Rieger
  • Laura Diaz Hernandez
  • Yuko Higuchi
  • Tomiki Sumiyoshi
  • Annarita Vignapiano
  • Giulia Maria Giordano
  • Antonella Amodio
  • Armida Mucci


The objective of the WPA section on Psychoneurobiology is the promotion of the integration of findings from research fields such as neurophysiology, psychology, neuropsychology and psychiatry. This chapter focuses on the importance of electroencephalographic (EEG) studies for the section’s objectives and especially for (a) the study of functional brain abnormalities related to liability to psychosis and schizophrenia pathophysiology and (b) characterization of schizophrenia psychopathological dimensions. The introduction will highlight the importance of EEG investigations in psychiatry, outlining a model of brain function, based on the notion of state-dependent information processing, and providing examples relevant to schizophrenia research. The second paragraph will summarize the current state of knowledge about resting state EEG connectivity in subjects with schizophrenia (SCZ) and draw some tentative conclusions about the possible links to the range of cognitive and behavioural abnormalities observed in these patients. The third paragraph will illustrate findings from event-related potential (ERP) studies of subjects at risk for psychosis who later develop schizophrenia-spectrum disorders. Some of the ERP parameters are proposed as biomarkers of the transition to psychosis and, if further validated, can be used to identify subjects for early interventions. The final paragraph of the chapter will summarize findings relevant to the characterization of the psychopathological dimensions of schizophrenia.


Resting state connectivity EEG microstates Event-related potentials High risk for psychosis Schizophrenia 


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2019

Authors and Affiliations

  • Martha Koukkou
    • 1
  • Thomas Koenig
    • 2
  • Anja Bänninger
    • 2
  • Kathryn Rieger
    • 2
  • Laura Diaz Hernandez
    • 2
  • Yuko Higuchi
    • 3
  • Tomiki Sumiyoshi
    • 4
  • Annarita Vignapiano
    • 5
  • Giulia Maria Giordano
    • 5
  • Antonella Amodio
    • 5
  • Armida Mucci
    • 5
  1. 1.The KEY Institute for Brain-Mind Research, Department of Psychiatry, Psychotherapy and PsychosomaticsUniversity Hospital of PsychiatryZurichSwitzerland
  2. 2.Translational Research Center, University Hospital of PsychiatryUniversity of BernBernSwitzerland
  3. 3.Department of NeuropsychiatryUniversity of Toyama Graduate School of Medicine and Pharmaceutical SciencesToyamaJapan
  4. 4.Department of Clinical EpidemiologyTranslational Medical Center, National Center of Neurology and PsychiatryTokyoJapan
  5. 5.Department of PsychiatryUniversity of Campania “Luigi Vanvitelli”NaplesItaly

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