The Role of Clozapine in Treatment-Resistant Schizophrenia

  • Kuppuswami ShivakumarEmail author
  • Shabbir Amanullah
  • Ranga Shivakumar
  • Kevin Saroka
  • Nicolas Rouleau
  • Nirosha J. Murugan


There have been various definitions of treatment-resistant schizophrenia recommended by practice guidelines and various clinical trials. No clear consensus exists for a single definition, but in general treatment resistance has been defined as an inadequate response to at least two different antipsychotic trials at the maximally tolerated dose. Clozapine is recommended for those patients with clinically significant positive symptoms after failure of two or more trials of antipsychotic medications. In this chapter, we will be discussing the side effects associated with clozapine treatment and also the role of the other professionals.


Clozapine Agranulocytosis Myocarditis Urinary incontinence 


Disclosure Statement

“The authors have nothing to disclose”.


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Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  • Kuppuswami Shivakumar
    • 1
    Email author
  • Shabbir Amanullah
    • 2
  • Ranga Shivakumar
    • 1
  • Kevin Saroka
    • 1
  • Nicolas Rouleau
    • 3
  • Nirosha J. Murugan
    • 4
  1. 1.Department of PsychiatryNorthern Ontario School of Medicine Psychiatry DepartmentSudburyCanada
  2. 2.University of Western OntarioWoodstock General Hospital University of Western OntarioWoodstockCanada
  3. 3.Department of Biomedical Engineering, Initiative for Neural ScienceDisease and Engineering (INScide) at Tufts University, Science and Engineering Complex (SEC)MedfordUSA
  4. 4.Allen Discovery Center at Tufts; Tufts Center for Regenerative and Developmental BiologyScience and Engineering Complex (SEC)MedfordUSA

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