Menopause, Estrogens, and Glucose Homeostasis in Women

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 1043)

Abstract

Randomized trials suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes. Still, the mechanisms of these antidiabetic effects are a matter of controversy. This chapter provides an analysis of epidemiological and clinical evidence and proposes a mechanism for the effect of menopause and MHT on type 2 diabetes development and prevention. It discusses the beneficial role of estradiol on glucose homeostasis that is lost at menopause and improved by MHT, which delays type 2 diabetes. This chapter aims to reconcile differences among studies of the effect of menopause and MHT formulations on type 2 diabetes and argues that discrepancies arise from physiological differences in methods used to assess glucose homeostasis.

Notes

Acknowledgments

This work was supported by grants from the National Institutes of Health (DK074970, DK107444), the American Diabetes Association (7-13-BS-101), and the VA Merit Review Award (BX003725).

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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Medicine, Section of Endocrinology and MetabolismTulane University Health Sciences Center, School of MedicineNew OrleansUSA

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