The Acutely Ill Child

  • Deirdre KellyEmail author


The main causes of liver disease in an acutely unwell older child are viral infection, drug injury or metabolic liver disease (Table 5.1). A thorough history may help distinguish from drug or toxin induced liver injury.

Further Reading

  1. Alonso E, Squires R. Acute liver failure. In: Kelly DA, editor. Diseases of the liver and biliary system in children, vol. 2017. 4th ed. Hoboken: Wiley. p. 271–90.CrossRefGoogle Scholar
  2. Devarbhavi H, Singh R, Adarsh CK, Sheth K, Kiran R, Patil M. Factors that predict mortality in children with Wilson disease associated acute liver failure and comparison of Wilson disease specific prognostic indices. J Gastroenterol Hepatol. 2014;29:380–6.CrossRefPubMedGoogle Scholar
  3. Lu BR, Zhang S, Narkewicz MR, et al. Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure. J Pediatr. 2013;162:1010-6.e1–4.CrossRefGoogle Scholar
  4. Squires RH Jr, Shneider BL, Bucuvalas J, et al. Acute liver failure in children: the first 348 patients in the pediatric acute liver failure study group. J Pediatr. 2006;148:652–8.CrossRefPubMedPubMedCentralGoogle Scholar

Copyright information

© Springer International Publishing AG, part of Springer Nature 2018

Authors and Affiliations

  1. 1.The Liver UnitBirmingham Women’s and Children’s HospitalBirminghamUK

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